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    System and methods for optimized drug delivery and progression of diseased and normal cells
    2.
    发明授权
    System and methods for optimized drug delivery and progression of diseased and normal cells 有权
    用于优化药物递送和患病和正常细胞进展的系统和方法

    公开(公告)号：US06871171B1

    公开(公告)日：2005-03-22

    申请号：US09691053

    申请日：2000-10-19

    申请人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    发明人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    IPC分类号： A61B5/00 ,  A61K45/06 ,  A61P43/00 ,  G01N20060101 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00 ,  G06N3/00

    CPC分类号： G06F19/3481 ,  G06F19/00 ,  G16H50/50

    摘要： Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.

    摘要翻译： 公开了为特定个体推荐最佳治疗方案的系统。 系统通常包括系统模型，多个处理协议，系统模型修改器，其中所述系统模型由系统模型修改器基于个体特有的参数来修改; 以及选择器，用于基于所述修改的系统模型从所述多个处理协议中选择最佳处理协议。 还公开了体现上述技术但是对于一般患者的系统。 公开了一般患者和个体用于各种特定疾病的系统。 还公开了体现上述技术的方法和计算机程序产品。

    System and methods for optimized drug delivery and progression of diseased and normal cells
    3.
    发明授权
    System and methods for optimized drug delivery and progression of diseased and normal cells 失效
    用于优化药物递送和患病和正常细胞进展的系统和方法

    公开(公告)号：US08504303B2

    公开(公告)日：2013-08-06

    申请号：US13531698

    申请日：2012-06-25

    申请人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    发明人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    IPC分类号： G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58

    CPC分类号： G06F19/3481 ,  G06F19/00 ,  G16H50/50

    摘要： System for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.

    摘要翻译： 公开了为特定个体推荐最佳治疗方案的系统。 系统通常包括系统模型，多个处理协议，系统模型修改器，其中所述系统模型由系统模型修改器基于个体特有的参数来修改; 以及选择器，用于基于所述修改的系统模型从所述多个处理协议中选择最佳处理协议。 还公开了体现上述技术但是对于一般患者的系统。 公开了一般患者和个体用于各种特定疾病的系统。 还公开了体现上述技术的方法和计算机程序产品。

    SYSTEM AND METHODS FOR OPTIMIZED DRUG DELIVERY AND PROGRESSION OF DISEASED AND NORMAL CELLS
    4.
    发明申请
    SYSTEM AND METHODS FOR OPTIMIZED DRUG DELIVERY AND PROGRESSION OF DISEASED AND NORMAL CELLS 失效
    用于优化药物递送和疾病和正常细胞进展的系统和方法

    公开(公告)号：US20120284005A1

    公开(公告)日：2012-11-08

    申请号：US13531698

    申请日：2012-06-25

    申请人： Zvia AGUR ,  Sarel FLEISHMANN ,  Kirill SKOMOROVSKI ,  Moshe VARDI

    发明人： Zvia AGUR ,  Sarel FLEISHMANN ,  Kirill SKOMOROVSKI ,  Moshe VARDI

    IPC分类号： A61K45/06 ,  G06F19/12 ,  A61B5/00

    CPC分类号： G06F19/3481 ,  G06F19/00 ,  G16H50/50

    摘要： System for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.

    摘要翻译： 公开了为特定个体推荐最佳治疗方案的系统。 系统通常包括系统模型，多个处理协议，系统模型修改器，其中所述系统模型由系统模型修改器基于个体特有的参数来修改; 以及选择器，用于基于所述修改的系统模型从所述多个处理协议中选择最佳处理协议。 还公开了体现上述技术但是对于一般患者的系统。 公开了一般患者和个体用于各种特定疾病的系统。 还公开了体现上述技术的方法和计算机程序产品。

    System and Methods for Optimized Drug Delivery and Progression of Diseased and Normal Cells
    5.
    发明申请
    System and Methods for Optimized Drug Delivery and Progression of Diseased and Normal Cells 有权
    用于优化的药物递送和疾病和正常细胞进展的系统和方法

    公开(公告)号：US20070213961A1

    公开(公告)日：2007-09-13

    申请号：US11680246

    申请日：2007-02-28

    申请人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    发明人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    IPC分类号： G06G7/60 ,  G06F17/10

    CPC分类号： G06F19/3481 ,  G06F19/00 ,  G16H50/50

    摘要： Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.

    摘要翻译： 公开了为特定个体推荐最佳治疗方案的系统。 系统通常包括系统模型，多个处理协议，系统模型修改器，其中所述系统模型由系统模型修改器基于个体特有的参数来修改; 以及选择器，用于基于所述修改的系统模型从所述多个处理协议中选择最佳处理协议。 还公开了体现上述技术但是对于一般患者的系统。 公开了一般患者和个体用于各种特定疾病的系统。 还公开了体现上述技术的方法和计算机程序产品。

    System and methods for optimized drug delivery and progression of diseased and normal cells
    6.
    发明授权
    System and methods for optimized drug delivery and progression of diseased and normal cells 有权
    用于优化药物递送和患病和正常细胞进展的系统和方法

    公开(公告)号：US07133814B2

    公开(公告)日：2006-11-07

    申请号：US09827229

    申请日：2001-04-06

    申请人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    发明人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    IPC分类号： G06N3/00 ,  G06G7/60

    CPC分类号： G06F19/3481 ,  G06F19/00 ,  G16H50/50

    摘要： A system for modeling thrombopoietic lineage in an individual is presented. The system comprises a thrombopoiesis system model including a process progression model, for cells involved in thrombopoiesis, said progression model including multiplication and differentiation. It further comprises a system model modifier, wherein said thrombopoiesis system model is modified by the system model modifier based on parameters specific to the individual. In addition to modifying an individual's thrombopoietic process, the system can be modified to portray different pathological scenarios as well as different scenarios of response to treatment.

    摘要翻译： 提出了一种用于建模个体血小板生成谱系统。 该系统包括血小板生成系统模型，其包括涉及血小板生成的细胞的过程进展模型，所述进展模型包括增殖和分化。 其还包括系统模型修改器，其中所述血小板生成系统模型由系统模型修改器基于个体特有的参数来修改。 除了修改个体的血小板生成过程之外，还可以修改系统来描绘不同的病理情景以及对治疗反应的不同场景。

    System and methods for optimized drug delivery and progression of diseased and normal cells
    7.
    发明授权
    System and methods for optimized drug delivery and progression of diseased and normal cells 有权
    用于优化药物递送和患病和正常细胞进展的系统和方法

    公开(公告)号：US08055491B2

    公开(公告)日：2011-11-08

    申请号：US11680246

    申请日：2007-02-28

    申请人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    发明人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    IPC分类号： G06G7/48 ,  G01N33/48 ,  G01N31/00

    CPC分类号： G06F19/3481 ,  G06F19/00 ,  G16H50/50

    摘要： Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.

    摘要翻译： 公开了为特定个体推荐最佳治疗方案的系统。 系统通常包括系统模型，多个处理协议，系统模型修改器，其中所述系统模型由系统模型修改器基于个体特有的参数来修改; 以及选择器，用于基于所述修改的系统模型从所述多个处理协议中选择最佳处理协议。 还公开了体现上述技术但是对于一般患者的系统。 公开了一般患者和个体用于各种特定疾病的系统。 还公开了体现上述技术的方法和计算机程序产品。

    System and methods for optimized drug delivery and progression of diseased and normal cells
    8.
    发明授权
    System and methods for optimized drug delivery and progression of diseased and normal cells 有权
    用于优化药物递送和患病和正常细胞进展的系统和方法

    公开(公告)号：US07266483B2

    公开(公告)日：2007-09-04

    申请号：US10192001

    申请日：2002-07-10

    申请人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    发明人： Zvia Agur ,  Sarel Fleishmann ,  Kirill Skomorovski ,  Moshe Vardi

    IPC分类号： G06N3/00

    CPC分类号： G06F19/3481 ,  G06F19/00 ,  G16H50/50

    摘要： Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.

    摘要翻译： 公开了为特定个体推荐最佳治疗方案的系统。 系统通常包括系统模型，多个处理协议，系统模型修改器，其中所述系统模型由系统模型修改器基于个体特有的参数来修改; 以及选择器，用于基于所述修改的系统模型从所述多个处理协议中选择最佳处理协议。 还公开了体现上述技术但是对于一般患者的系统。 公开了一般患者和个体用于各种特定疾病的系统。 还公开了体现上述技术的方法和计算机程序产品。