公开(公告)号：US5833945A

公开(公告)日：1998-11-10

申请号：US928151

申请日：1997-09-12

申请人： Moto Sakuma

发明人： Moto Sakuma

IPC分类号： A01K67/02 ,  A61K49/00 ,  A01K29/00

CPC分类号： A01K67/02

摘要： The present invention provides a phenotypically stable altered animal which exhibits unprovoked rage reaction indicative of high emotionality, stereotyped behavior and is useful as a model of psychotic behavior. The animals of this invention (F.sub.2) were obtained by inbreeding mature offspring (F.sub.1) of rats whose mothers received high tryptophan diets during their third trimester of gestation. There is also an increased body weight which evidences physical alteration. The present invention also relates to the preparation and use of animal models for the study of psychosis, pathological psychotic behavior in humans and the effects of tryptophan in successive generations. The prenatal effects of tryptophan on later generations can also be used to increase the body weight of experimental animals and livestock.

摘要翻译： 本发明提供了表型稳定的改变的动物，其表现出无情的愤怒反应，表明高情绪，刻板行为，并且作为精神病行为的模型是有用的。 本发明的动物（F2）通过在母亲在妊娠第三个月期间接受高色氨酸饮食的大鼠的成熟后代（F1）近亲获得。 体重增加也体现了身体的改变。 本发明还涉及用于研究精神病，人类病理性精神病性行为和色氨酸在连续世代中的作用的动物模型的制备和应用。 色氨酸对后代的产前影响也可用于增加实验动物和家畜的体重。