公开(公告)号：US20110166132A1

公开(公告)日：2011-07-07

申请号：US12746902

申请日：2008-12-12

申请人： Stephen A. Hitchcock ,  Jian J. Chen ,  Mqhele Vellah Ncube ,  Thomas Nixey ,  Albert Amegadzie ,  Roxanne Kunz ,  Wenyan Qian ,  Ning Chen ,  Christopher M. Tegley ,  Frenel F. De Morin ,  Chester Chenguang Yuan ,  Qingyian Liu ,  Jiawang Zhu ,  Tanya A.N. Peterkin ,  Jeffrey A. Adams ,  Essa Hu ,  Frank Chavez, JR.

发明人： Stephen A. Hitchcock ,  Jian J. Chen ,  Mqhele Vellah Ncube ,  Thomas Nixey ,  Albert Amegadzie ,  Roxanne Kunz ,  Wenyan Qian ,  Ning Chen ,  Christopher M. Tegley ,  Frenel F. De Morin ,  Chester Chenguang Yuan ,  Qingyian Liu ,  Jiawang Zhu ,  Tanya A.N. Peterkin ,  Jeffrey A. Adams ,  Essa Hu ,  Frank Chavez, JR.

IPC分类号： A61K31/538 ,  C07D213/56 ,  C07D413/12 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D405/12 ,  C07D233/61 ,  C07D403/12 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/4164 ,  A61K31/4178 ,  A61P25/28

CPC分类号： C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12

摘要： The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

摘要翻译： 本发明提供了γ-分泌酶调节剂的化合物，因此可用于治疗通过调节γ分泌酶如阿尔茨海默病可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US07553848B2

公开(公告)日：2009-06-30

申请号：US11041169

申请日：2005-01-21

申请人： Christopher Hulme ,  Mqhele Vellah Ncube ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Liping H. Pettus ,  Jiawang Zhu

发明人： Christopher Hulme ,  Mqhele Vellah Ncube ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Liping H. Pettus ,  Jiawang Zhu

IPC分类号： A61K31/44 ,  A61K31/351 ,  A61K31/415 ,  A61K31/425 ,  C07D235/30 ,  C07D319/14 ,  C07D405/02 ,  C07D417/02 ,  C07D471/02

CPC分类号： C07D495/04 ,  C07D209/08 ,  C07D215/38 ,  C07D235/06 ,  C07D277/82 ,  C07D319/18 ,  C07D319/20 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12

摘要： bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

摘要翻译： 双环酰胺及其衍生物和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎 ，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱疾病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎症性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，糖尿病性神经病变 疼痛，咳嗽症状，交感神经保持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动性紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风， 混乱 rs，胃溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。