Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation
    1.
    发明申请
    Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation 审中-公开
    聚合物包被的纳米纤维结构和细胞维持和分化的方法

    公开(公告)号:US20070082393A1

    公开(公告)日:2007-04-12

    申请号:US11489964

    申请日:2006-07-20

    IPC分类号: C12N5/06 C12N5/08 C12M1/12

    摘要: The invention provides cell-adherent polymeric coatings for articles having a nanofibrillar structure. The coatings include a synthetic, non-biodegradable polymer having at least one pendent amine group, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long term culturing of cells using the polymer coated nanofibrillar structures. The polymer coated nanofibrillar structures of the invention have been found to be particularly useful for the growth and differentiation of cells, including neural precursors.

    摘要翻译: 本发明提供了具有纳米纤维结构的制品的细胞粘附聚合物涂层。 涂层包括具有至少一个侧挂胺基团的合成的,不可生物降解的聚合物,其中聚合物通过潜在的反应性基团共价固定在制品上。 本发明还提供了使用聚合物包被的纳米纤维结构长期培养细胞的方法。 已经发现本发明的聚合物包被的纳米纤丝结构对于包括神经前体在内的细胞的生长和分化特别有用。