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公开(公告)号：US09738893B2
公开(公告)日：2017-08-22
申请号：US15004104
申请日：2016-01-22
IPC分类号： C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/141 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Y101/01034 , C12Y205/01021
摘要： The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
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2.发明申请公开(公告)号：US20180010127A1
公开(公告)日：2018-01-11
申请号：US15646437
申请日：2017-07-11
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/141 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Y101/01034 , C12Y205/01021
摘要： The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
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3.发明授权Method of enhancing miR-185 expression to reduce low density lipoprotein/cholesterol accumulation in a cell 有权增强miR-185表达以降低细胞中低密度脂蛋白/胆固醇积累的方法公开(公告)号：US09243250B2
公开(公告)日：2016-01-26
申请号：US13919141
申请日：2013-06-17
IPC分类号： C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/141 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Y101/01034 , C12Y205/01021
摘要： The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
摘要翻译： 本发明提供了定量miR-185作为人类脂质障碍或心血管疾病的潜在生物标志物的方法。 本发明还提供调节miR-185调节细胞中LDL和胆固醇代谢的方法。 本发明在治疗人类胆固醇/低密度脂蛋白相关心血管疾病方面具有治疗潜力。
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4.发明申请A METHOD OF ENHANCING MIR-185 EXPRESSION TO REDUCE LOW DENSITY LIPOPROTEIN/CHOLESTEROL ACCUMULATION IN A CELL 有权一种增强MIR-185表达以减少细胞中低密度脂蛋白/胆固醇积累的方法公开(公告)号：US20130337459A1
公开(公告)日：2013-12-19
申请号：US13919141
申请日：2013-06-17
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/141 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Y101/01034 , C12Y205/01021
摘要： The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
摘要翻译： 本发明提供了定量miR-185作为人类脂质障碍或心血管疾病的潜在生物标志物的方法。 本发明还提供调节miR-185调节细胞中LDL和胆固醇代谢的方法。 本发明在治疗人类胆固醇/低密度脂蛋白相关心血管疾病方面具有治疗潜力。
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5.发明申请METHOD OF ENHANCING MIR-185 EXPRESSION TO REDUCE LOW DENSITY LIPOPROTEIN/CHOLESTEROL ACCUMULATION IN A CELL 审中-公开增强MIR-185表达以减少细胞中低密度脂蛋白/胆固醇积累的方法公开(公告)号：US20160194635A1
公开(公告)日：2016-07-07
申请号：US15004104
申请日：2016-01-22
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/141 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Y101/01034 , C12Y205/01021
摘要： The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
摘要翻译： 本发明提供了定量miR-185作为人类脂质障碍或心血管疾病的潜在生物标志物的方法。 本发明还提供调节miR-185调节细胞中LDL和胆固醇代谢的方法。 本发明在治疗人类胆固醇/低密度脂蛋白相关心血管疾病方面具有治疗潜力。
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