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公开(公告)号：US20180216125A1
公开(公告)日：2018-08-02
申请号：US15937575
申请日：2018-03-27
发明人： Haruhiko YAMAGUCHI , Yukino INOUE , Satoshi KURODA
IPC分类号： C12N15/82 , C07K14/415 , C12P5/00 , C12N9/04
CPC分类号： C12N15/8216 , C07K14/415 , C12N9/0006 , C12N15/8243 , C12P5/007 , C12Y101/01034
摘要： The present invention provides methods for enhancing the polyisoprenoid biosynthesis pathway. The present invention further provides isoprenoid-producing plants having an enhanced polyisoprenoid biosynthesis pathway, and methods for producing a polyisoprenoid using such an isoprenoid-producing plant. The present invention relates to methods for regulating the expression of specific protein(s) by a specific transcription factor; isoprenoid-producing plants into which has been introduced a gene encoding a specific transcription factor; and methods for producing a polyisoprenoid using such an isoprenoid-producing plant.
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公开(公告)号：US09957516B2
公开(公告)日：2018-05-01
申请号：US14758166
申请日：2014-01-09
发明人： Haruhiko Yamaguchi , Yukino Inoue , Satoshi Kuroda
IPC分类号： C12N15/82 , C12N9/04 , C07K14/415 , C12P5/00
CPC分类号： C12N15/8216 , C07K14/415 , C12N9/0006 , C12N15/8243 , C12P5/007 , C12Y101/01034
摘要： The present invention provides methods for enhancing the polyisoprenoid biosynthesis pathway. The present invention further provides isoprenoid-producing plants having an enhanced polyisoprenoid biosynthesis pathway, and methods for producing a polyisoprenoid using such an isoprenoid-producing plant. The present invention relates to methods for regulating the expression of specific protein(s) by a specific transcription factor; isoprenoid-producing plants into which has been introduced a gene encoding a specific transcription factor; and methods for producing a polyisoprenoid using such an isoprenoid-producing plant.
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公开(公告)号：US09850504B2
公开(公告)日：2017-12-26
申请号：US14902565
申请日：2014-07-02
IPC分类号： C12N9/88 , C12P7/16 , C12N1/00 , C12P5/02 , C12P7/26 , C12N9/04 , C12N9/02 , C12N15/52 , C12P7/04 , C12N15/70 , C12P19/32
CPC分类号： C12P7/16 , C12N1/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/88 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/04 , C12P7/26 , C12P19/32 , C12Y101/01001 , C12Y101/0103 , C12Y101/01034 , C12Y101/01184 , C12Y102/0105 , C12Y103/08001 , C12Y402/01017 , C12Y402/01018 , C12Y402/01055 , C12Y402/01059 , C12Y402/01074 , C12Y402/01116 , C12Y402/01127 , Y02E50/10
摘要： Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.
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公开(公告)号：US20170088824A1
公开(公告)日：2017-03-30
申请号：US15302903
申请日：2015-04-09
申请人： ADEKA CORPORATION
CPC分类号： C12N9/0006 , C12N15/52 , C12P5/007 , C12Y101/01034 , C12Y101/01088
摘要： The object of the present invention is to efficiently produce useful terpenoid compounds, and specifically, to provide a method for preparing squalene, which is an important intermediate of terpenoid. The object can be solved by a hydroxymethylglutaryl CoA reductase (HMGR) comprising:(a) an amino acid other than alanine (A) at the 10th position in an Sα2 amino acid sequence of HMGR, (b) an amino acid other than proline (P) at the 1st position from the carboxyl terminal in the DKK region of the HMG-CoA binding site of HMGR, (c) an amino acid other than alanine (A) at the 1st position in an Lα2 amino acid sequence of HMGR, and (d) an amino acid other than glutamic acid (E) at the 6th position in an Lα2 amino acid sequence of HMGR of the present invention.
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公开(公告)号：US09598710B2
公开(公告)日：2017-03-21
申请号：US14491212
申请日：2014-09-19
申请人： Christine Lang , Andreas Raab
发明人： Christine Lang , Andreas Raab
IPC分类号： C12N15/81 , C12P7/64 , A61K8/99 , A61Q19/00 , C12N9/02 , C12N9/10 , C12P5/00 , C12P33/00 , C12N9/04
CPC分类号： C12P7/6463 , A61K8/99 , A61Q19/00 , C12N9/0006 , C12N9/0071 , C12N9/1007 , C12N9/1029 , C12N15/81 , C12P5/007 , C12P7/6436 , C12P7/649 , C12P33/00 , C12Y101/01034 , C12Y203/0102 , C12Y203/01026 , Y02E50/343 , Y02P20/52
摘要： The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.
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公开(公告)号：US20160369306A1
公开(公告)日：2016-12-22
申请号：US14902565
申请日：2014-07-02
IPC分类号： C12P7/16 , C12N9/88 , C12N15/52 , C12N15/70 , C12P7/26 , C12P19/32 , C12N9/02 , C12N9/04 , C12P5/02
CPC分类号： C12P7/16 , C12N1/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/88 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/04 , C12P7/26 , C12P19/32 , C12Y101/01001 , C12Y101/0103 , C12Y101/01034 , C12Y101/01184 , C12Y102/0105 , C12Y103/08001 , C12Y402/01017 , C12Y402/01018 , C12Y402/01055 , C12Y402/01059 , C12Y402/01074 , C12Y402/01116 , C12Y402/01127 , Y02E50/10
摘要： Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.
摘要翻译： 描述了制备3-丁烯-2-酮的方法，其包括通过使用催化4-羟基-2-丁酮脱水的酶将4-羟基-2-丁酮酶促转化成3-丁烯-2-酮 其中所述催化4-羟基-2-丁酮脱水的酶是（a）3-羟基丙酰辅酶A脱水酶（EC 4.2.1.116），（b）3-羟基丁酰辅酶A脱水酶（EC 4.2.1.55），（c ）烯酰辅酶A水合酶（EC 4.2.1.17），（d）3-羟基辛酰 - [酰基 - 载体 - 蛋白]脱水酶（EC 4.2.1.59），（e）巴豆酰基 - [酰基 - 载体 - 蛋白]水合酶 （EC 4.2.1.58），（f）3-羟基癸酰基 - [酰基 - 载体 - 蛋白质]脱水酶（EC 4.2.1.60），（g）3-羟基棕榈酰 - [酰基 - 载体 - 蛋白质]脱水酶（EC 4.2。 1.61），（h）长链烯酰辅酶A水合酶（EC 4.2.1.74），或（i）3-甲基谷丙酰辅酶A水合酶（EC 4.2.1.18）。 生成的3-丁烯-2-酮可进一步转化为3-丁烯-2-醇，最后进一步转化为1,3-丁二烯。
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7.发明申请METHOD FOR ADJUSTING EXPRESSION OF HYDROXYMETHYLGLUTARYL COA REDUCTASE USING BZIP-TYPE TRANSCRIPTION FACTOR, ISOPRENOID-PRODUCING PLANT INTO WHICH GENE ENCODED FOR BZIP-TYPE TRANSCRIPTION FACTOR IS INTRODUCED, AND METHOD FOR MANUFACTURING POLYISOPRENOID IN WHICH SAID PLANT IS USED 审中-公开使用BZIP型转录因子调节羟丙基乳糖降解酶的表达方法，用于生产BZIP型转录因子的基因编码的异吲哚生产植物的方法，以及制造使用该植物的聚异戊二烯的方法公开(公告)号：US20160251632A1
公开(公告)日：2016-09-01
申请号：US14902191
申请日：2014-07-07
发明人： Haruhiko YAMAGUCHI , Yukino INOUE , Satoshi KURODA
CPC分类号： C12N9/0006 , C12N15/8216 , C12N15/8237 , C12N15/8243 , C12N15/8257 , C12P5/007 , C12Y101/01034
摘要： The present invention provides a method enhancing the polyisoprenoid biosynthesis pathway. Also provided are an isoprenoid-producing plant having an overall enhanced pathway of polyisoprenoid biosynthesis, and a method of producing a polyisoprenoid using the isoprenoid-producing plant. The present invention relates to a method of regulating the expression of hydroxymethylglutaryl-CoA reductase by a bZIP transcription factor.
摘要翻译： 本发明提供增强聚异戊二烯生物合成途径的方法。 还提供具有总体增强的聚异戊二烯生物合成途径的类异戊二烯生产植物，以及使用产生异戊二烯的植物生产聚异戊二烯的方法。 本发明涉及通过bZIP转录因子调节羟甲基戊二酰辅酶A还原酶的表达的方法。
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8.发明申请VECTOR COMPRISING SPECIFIC PROMOTER AND GENE ENCODING SPECIFIC PROTEIN, TRANSGENIC PLANT INTO WHICH THE VECTOR HAS BEEN INTRODUCED, AND METHOD FOR IMPROVING POLYISOPRENOID PRODUCTION BY INTRODUCING THE VECTOR INTO PLANT 审中-公开包含特定促进剂和基因编码特异性蛋白质的载体，已经介绍的载体的转基因植物，以及通过将植物引入植物来改进聚异戊二烯生产的方法公开(公告)号：US20160244774A1
公开(公告)日：2016-08-25
申请号：US15018504
申请日：2016-02-08
发明人： Yukino INOUE , Akari OKADA , Haruhiko YAMAGUCHI , Satoshi KURODA
CPC分类号： C12N15/8251 , C07K14/415 , C12N9/0006 , C12N9/1085 , C12N9/90 , C12N15/52 , C12N15/8223 , C12N15/8243 , C12Y101/01034 , C12Y205/01 , C12Y205/0101 , C12Y205/0102 , C12Y503/03002
摘要： Provided is a vector capable of improving polyisoprenoid production through the introduction of the vector into a plant using gene recombination techniques. A vector comprising: a promoter of a gene encoding Hevein 2.1; and a gene encoding a protein involved in polyisoprenoid biosynthesis, the gene being functionally linked to the promoter.
摘要翻译： 提供了能够通过使用基因重组技术将载体引入植物来改善聚异戊二烯生产的载体。 一种载体，其包含：编码Hevein 2.1的基因的启动子; 以及编码涉及聚异戊二烯生物合成的蛋白质的基因，该基因与启动子功能性连接。
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9.发明申请VECTOR COMPRISING SPECIFIC PROMOTER AND GENE ENCODING SPECIFIC PROTEIN, TRANSGENIC PLANT INTO WHICH THE VECTOR HAS BEEN INTRODUCED, AND METHOD FOR IMPROVING POLYISOPRENOID PRODUCTION BY INTRODUCING THE VECTOR INTO PLANT 审中-公开包含特定促进剂和基因编码特异性蛋白质的载体，已经介绍的载体的转基因植物，以及通过将植物引入植物来改进聚异戊二烯生产的方法公开(公告)号：US20160244773A1
公开(公告)日：2016-08-25
申请号：US15018439
申请日：2016-02-08
发明人： Yukino INOUE , Akari OKADA , Haruhiko YAMAGUCHI , Satoshi KURODA
IPC分类号： C12N15/82 , C12N9/90 , C12N9/04 , C07K14/415 , C12N9/10
CPC分类号： C12N15/8243 , C07K14/415 , C12N9/0006 , C12N9/1085 , C12N9/90 , C12N15/8209 , C12N15/8223 , C12P5/007 , C12Y101/01034 , C12Y205/0101 , C12Y205/0102 , C12Y205/01029 , C12Y503/03002
摘要： Provided is a vector capable of improving polyisoprenoid production through the introduction of the vector into a plant using gene recombination techniques. A vector comprising: a promoter of a gene encoding Small Rubber Particle Protein; and a gene encoding a protein involved in polyisoprenoid biosynthesis, the gene being functionally linked to the promoter.
摘要翻译： 提供了能够通过使用基因重组技术将载体引入植物来改善聚异戊二烯生产的载体。 一种载体，其包含：编码小橡胶颗粒蛋白的基因的启动子; 以及编码涉及聚异戊二烯生物合成的蛋白质的基因，该基因与启动子功能性连接。
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10.发明申请METHOD OF ENHANCING MIR-185 EXPRESSION TO REDUCE LOW DENSITY LIPOPROTEIN/CHOLESTEROL ACCUMULATION IN A CELL 审中-公开增强MIR-185表达以减少细胞中低密度脂蛋白/胆固醇积累的方法公开(公告)号：US20160194635A1
公开(公告)日：2016-07-07
申请号：US15004104
申请日：2016-01-22
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/141 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Y101/01034 , C12Y205/01021
摘要： The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
摘要翻译： 本发明提供了定量miR-185作为人类脂质障碍或心血管疾病的潜在生物标志物的方法。 本发明还提供调节miR-185调节细胞中LDL和胆固醇代谢的方法。 本发明在治疗人类胆固醇/低密度脂蛋白相关心血管疾病方面具有治疗潜力。
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