公开(公告)号：US20130103079A1

公开(公告)日：2013-04-25

申请号：US13659861

申请日：2012-10-24

申请人： Novo Contour, Inc.

发明人： Michael P.H. Lau ,  Leonard Pease

IPC分类号： C08L83/04 ,  A61L17/08 ,  A61L17/00

CPC分类号： A61L17/08

摘要： A material comprising two or more fibers, wherein each of the fibers has a mechanical modulus, and the mechanical modulus of at least one fiber is higher than the mechanical modulus of another fiber. The higher modulus fiber has a longer length than the lower modulus fiber. In various embodiments, the higher modulus fiber is collagen mimetic and the lower modulus fiber is elastin mimetic. A suture is also described, comprising two or more fibers. At least one of the fibers is elastin-like and has a lower elastic modulus than another fiber that is collagen-like and has a higher elastic modulus. The higher modulus collagen-like fiber is longer than the lower modulus elastin-like fiber.

摘要翻译： 包含两种或更多种纤维的材料，其中每种纤维具有机械模量，并且至少一种纤维的机械模量高于另一种纤维的机械模量。 较高模量的纤维具有比下模量纤维更长的长度。 在各种实施方案中，较高模量纤维是胶原蛋白模拟物，较低模量纤维是弹性蛋白模拟物。 还描述了包括两根或更多根纤维的缝合线。 纤维中的至少一种是弹性蛋白样的并且具有比另一种胶原样的纤维具有更低的弹性模量并且具有较高的弹性模量。 较高模量的胶原样纤维比下模弹性蛋白样纤维长。

公开(公告)号：US20140276995A1

公开(公告)日：2014-09-18

申请号：US13831159

申请日：2013-03-14

申请人： NOVO CONTOUR, INC.

发明人： Michael P.H. Lau ,  Leonard Pease

IPC分类号： A61F2/00

CPC分类号： A61F2/0063 ,  A61F2/0045 ,  A61F2013/00604

摘要： A stressed timed-release multilayer composite, comprising a first stressed layer, and a second layer and third layer that hold the first layer under said stress. The second and third layers are configured to at least partially change to release at least a portion of the stress of the first layer in response to the second layer and/or the third layer being at least partially changed. Also disclosed is a stressed timed-release bilayer composite, comprising a first stressed layer and a second layer that holds the first layer under said stress forming a first physical curvature of the composite, wherein one or both of the first and/or second layers are configured to at least partially change and thereby form a second physical curvature. A stressed timed-release multilayer core-shell fiber is further disclosed.

摘要翻译： 一种应力定时释放多层复合材料，包括第一应力层和在所述应力下保持第一层的第二层和第三层。 第二层和第三层被配置为至少部分地改变以响应于第二层和/或第三层至少部分地改变而释放第一层的应力的至少一部分。 还公开了一种应力定时释放双层复合材料，其包括第一应力层和第二层，其在所述应力下保持第一层，形成复合材料的第一物理曲率，其中第一和/或第二层中的一个或两个为 被配置为至少部分地改变并由此形成第二物理曲率。 进一步公开了应力定时释放多层芯壳纤维。

公开(公告)号：US20140081295A1

公开(公告)日：2014-03-20

申请号：US14027115

申请日：2013-09-13

申请人： Novo Contour, Inc.

发明人： Michael P.H. Lau ,  Leonard Pease

IPC分类号： A61F2/00

CPC分类号： A61F2/0077 ,  A61F2/0063 ,  A61F2002/0081 ,  A61F2220/0008 ,  A61L17/145 ,  A61L31/088 ,  A61L31/14 ,  A61L2400/12

摘要： An adhesive surface comprises at least a nanoparticle coating, a metallic coating, or a fiber with a micro/nano patterned topology. The adhesive surface is adhesive to tissue in a living body. The nanoparticle coating may be metallic. In some embodiments, the adhesive surface constitutes one or more elements of a bandage or surgical mesh, is a surface of a suture, or is sized, shaped, and configured for surgical application in a body. The surface or fiber may further comprise or be encased in a dissolvable coating, such as a polysaccharide, oligosaccharide, or sucrose. The fiber may have a surface that is patterned in topological relief, such as ridges in various orientations, cylindrical protrusions substantially normal the fiber surface, undulations of the fiber surface, or random asperities of the fiber surface. The patterning may be less than 700 nm or greater than 10 microns.

摘要翻译： 粘合剂表面至少包括纳米颗粒涂层，金属涂层或具有微/纳米图案拓扑的纤维。 粘合剂表面与生物体中的组织粘合。 纳米颗粒涂层可以是金属的。 在一些实施例中，粘合剂表面构成绷带或外科手术网的一个或多个元件，是缝合线的表面，或者其尺寸，形状和构造用于外科手术应用于体内。 表面或纤维可以进一步包含或包裹在可溶解的涂层中，例如多糖，寡糖或蔗糖。 纤维可以具有在拓扑形状中图案化的表面，例如各种取向的脊，基本上垂直于纤维表面的圆柱形突起，纤维表面的起伏或纤维表面的随机粗糙度。 图案化可以小于700nm或大于10微米。

公开(公告)号：US20130090521A1

公开(公告)日：2013-04-11

申请号：US13648188

申请日：2012-10-09

申请人： Novo Contour, Inc.

发明人： Michael P.H. Lau ,  Leonard Pease

IPC分类号： A61F2/02 ,  A61B17/04

CPC分类号： D06M15/507 ,  A61B17/06166 ,  A61B2017/00805 ,  A61F2/0045 ,  A61L17/06 ,  A61L31/14 ,  A61L31/145 ,  D06M15/70

摘要： A timed-release tensioned core-shell fiber comprises a core positioned within a shell. The shell is configured to hold the core under said tension or compression. The shell is at least partially removable and releases at least a portion of the tension or compression of the core in response to the shell being removed. The shell is at least partially removable by erosion or degradation due to mechanical, chemical, electrical, physical, or thermal processes, or combinations thereof. In some embodiments, the erosion or degradation of the shell may include biodegradation, bioerosion, photooxidation, or photodegradation. A fiber mesh comprised of core-shell fibers may be tuned for timed release of contraction or expansion forces in response to timed release of tension or compression of the core. The fiber mesh may be used in a medical device, bandage, implant, tissue construct, or sling. A suture may also comprise a core-shell fiber.

摘要翻译： 定时释放张紧的芯壳纤维包括定位在外壳内的芯。 壳体构造成将芯保持在所述张力或压缩之下。 壳体至少部分可移除并且响应于壳体被移除而释放芯部的张力或压缩的至少一部分。 壳体由于机械，化学，电学，物理或热过程或其组合而被侵蚀或降解至少部分地除去。 在一些实施方案中，壳的侵蚀或降解可包括生物降解，生物侵蚀，光氧化或光降解。 可以调节由芯 - 壳纤维构成的纤维网，以响应于芯的定时释放张力或压缩而定时释放收缩或膨胀力。 纤维网可用于医疗器械，绷带，植入物，组织结构或吊带。 缝合线还可以包括核 - 壳纤维。