公开(公告)号：US20240245609A1

公开(公告)日：2024-07-25

申请号：US18576866

申请日：2021-07-20

申请人： NOVOCODEX BIOPHARMACEUTICALS CO., LTD.

发明人： Lihai XIAO ,  Jiali CHEN ,  Moutian YE ,  Gang XIA ,  Jingjing ZHU ,  Lei FANG ,  Yuebin YING ,  Luxiong YE ,  Xuejun LIANG

IPC分类号： A61K9/19 ,  A61K47/18 ,  A61K47/26 ,  A61K47/68

CPC分类号： A61K9/19 ,  A61K47/183 ,  A61K47/26 ,  A61K47/68031 ,  A61K47/6855

摘要： The present invention provides a freeze-dried composition containing anti-HER2 drug conjugate, which comprises ARX788 and one or more of pharmaceutically acceptable lyoprotectant, buffer salts and surfactants, wherein the pH value of the freeze-dried composition is from 5.7 to 6.3. The present invention also provides a freeze-dried preparation containing anti-HER2 drug conjugate and the preparation method thereof. The present invention also provides use of the freeze-dried composition and the freeze-dried preparation. The freeze-dried composition and the freeze-dried preparation provided by the present invention have a very excellent stability, as well as good appearance, short reconstitution time and low moisture content. The product quality is safe and reliable, and the production efficiency is high. The preparation methods of the freeze-dried composition and the freeze-dried preparation provided by the present invention are simple and have low-cost, and they can be used for treating various cancers, and have broad application prospects.

公开(公告)号：US20240317832A1

公开(公告)日：2024-09-26

申请号：US18578487

申请日：2021-07-29

申请人： NOVOCODEX BIOPHARMACEUTICALS CO., LTD.

发明人： Jinwei YANG ,  Chenghao YE ,  Gang XIA ,  Pengchao HUO ,  Wen DING ,  Longfei CHEN ,  Lin JIAO ,  Hao HUANG ,  Xin HENG ,  Jingjing ZHU ,  Yuebin YING ,  Xuejun LIANG

IPC分类号： C07K14/61 ,  A61K38/00 ,  A61K47/60 ,  C07C235/20 ,  C07C235/78 ,  C07C237/12 ,  C07C271/22 ,  C07C271/54 ,  C07K1/00

CPC分类号： C07K14/61 ,  A61K47/60 ,  C07C235/20 ,  C07C235/78 ,  C07C237/12 ,  C07C271/22 ,  C07C271/54 ,  C07K1/006 ,  A61K38/00

摘要： An unnatural amino acid may have a structure as shown in formula (1) or may be an enantiomer thereof:




Such unnatural amino acid may be used, e.g., in recombinant proteins. A recombinant protein may contain such unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid can be simple and convenient to prepare, safe in nature, difficult to inactivate when inserted into a protein, and may have a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate.