公开(公告)号：US20240317832A1

公开(公告)日：2024-09-26

申请号：US18578487

申请日：2021-07-29

申请人： NOVOCODEX BIOPHARMACEUTICALS CO., LTD.

发明人： Jinwei YANG ,  Chenghao YE ,  Gang XIA ,  Pengchao HUO ,  Wen DING ,  Longfei CHEN ,  Lin JIAO ,  Hao HUANG ,  Xin HENG ,  Jingjing ZHU ,  Yuebin YING ,  Xuejun LIANG

IPC分类号： C07K14/61 ,  A61K38/00 ,  A61K47/60 ,  C07C235/20 ,  C07C235/78 ,  C07C237/12 ,  C07C271/22 ,  C07C271/54 ,  C07K1/00

CPC分类号： C07K14/61 ,  A61K47/60 ,  C07C235/20 ,  C07C235/78 ,  C07C237/12 ,  C07C271/22 ,  C07C271/54 ,  C07K1/006 ,  A61K38/00

摘要： An unnatural amino acid may have a structure as shown in formula (1) or may be an enantiomer thereof:




Such unnatural amino acid may be used, e.g., in recombinant proteins. A recombinant protein may contain such unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid can be simple and convenient to prepare, safe in nature, difficult to inactivate when inserted into a protein, and may have a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate.