公开(公告)号：US20050136126A1

公开(公告)日：2005-06-23

申请号：US11028767

申请日：2005-01-03

Applicant: Ki Keum ,  Naechoon Yoo ,  Won-min Yoo

Inventor： Ki Keum ,  Naechoon Yoo ,  Won-min Yoo

IPC: A61K33/00 ,  A61K33/42

CPC classification number: A61K31/133 ,  A61K31/19 ,  A61K33/00 ,  A61K33/42

Abstract: The present invention relates to an agent for reducing scar formation, which inhibits the scar formation by injecting sodium bicarbonate to the dermis tissue of the wound with a syringe to directly control pH of the wound site, namely, by alkalinizing the wound to inactivate TGF-β. According to the present invention, the agent for reducing scar formation by controlling the wound healing process can be clinically and immediately applied to the treatment of tylosis scar and keloid, etc., and is effective to the treatment of intractable fibrosis diseases. Also, the invention can be widely applied in many ways as an easy tool which can control the action of TGF-β in a living organism.

Abstract translation: 本发明涉及一种用于减少瘢痕形成的药剂，其通过用注射器将碳酸氢钠注入伤口的真皮组织来抑制瘢痕形成，以直接控制伤口部位的pH，即通过使伤口碱化以使TGF- 测试版 根据本发明，通过控制伤口愈合过程来减少瘢痕形成的药剂可以临床上立即应用于治疗泰乐菌瘢痕和瘢痕疙瘩等，对于治疗难治性纤维化疾病是有效的。 此外，本发明可以以许多方式广泛应用，作为可以控制活体中TGF-β的作用的简单工具。

公开(公告)号：US07323184B2

公开(公告)日：2008-01-29

申请号：US11476543

申请日：2006-06-28

Applicant: Mary Ellen Freddo ,  Ki Chang Keum ,  Naechoon Yoo ,  Won Min Yoo

Inventor： Mary Ellen Freddo ,  Ki Chang Keum ,  Naechoon Yoo ,  Won Min Yoo

IPC: A61K9/00 ,  A61K9/50 ,  A61K33/00 ,  A01N43/04

CPC classification number: A61K33/00 ,  A61K31/728 ,  A61K45/06

Abstract: The present invention relates to methods and compositions for inhibiting scar formation on wound region. In certain embodiments, the methods include administering an alkalinization agent in combination with hyaluronic acid to a wound site to reduce the formation of scars at the wound site. Suitable alkalization agents include sodium bicarbonate, sodium hydroxide and potassium hydroxide.

Abstract translation: 本发明涉及用于抑制伤口区域上的瘢痕形成的方法和组合物。 在某些实施方案中，所述方法包括向伤口部位施用与透明质酸组合的碱化剂以减少伤口位置处的瘢痕形成。 合适的碱化剂包括碳酸氢钠，氢氧化钠和氢氧化钾。

公开(公告)号：US07255883B2

公开(公告)日：2007-08-14

申请号：US10312097

申请日：2001-06-20

Applicant: Ki Chang Keum ,  Naechoon Yoo ,  Won-min Yoo

Inventor： Ki Chang Keum ,  Naechoon Yoo ,  Won-min Yoo

IPC: A01N59/00 ,  A61K33/00

CPC classification number: A61K33/00

Abstract: The present invention relates to an agent for reducing scar formation, which inhibits the scar formation by injecting sodium bicarbonate to the dermis tissue of the wound with a syringe to directly control pH of the wound site, namely, by alkalinizing the wound to inactivate TGF-β. According to the present invention, the agent for reducing scar formation by controlling the wound healing process can be clinically and immediately applied to the treatment of tylosis scar and keloid, etc., and is effective to the treatment of intractable fibrosis diseases. Also, the invention can be widely applied in many ways as an easy tool which can control the action of TGF-β in a living organism.

Abstract translation: 本发明涉及一种用于减少瘢痕形成的药剂，其通过用注射器将碳酸氢钠注入伤口的真皮组织来抑制瘢痕形成，以直接控制伤口部位的pH，即通过使伤口碱化以使TGF- 测试版 根据本发明，通过控制伤口愈合过程来减少瘢痕形成的药剂可以临床上立即应用于治疗泰乐菌瘢痕和瘢痕疙瘩等，对于治疗难治性纤维化疾病是有效的。 此外，本发明可以以许多方式广泛应用，作为可以控制活体中TGF-β的作用的简单工具。

公开(公告)号：US20070059377A1

公开(公告)日：2007-03-15

申请号：US11476543

申请日：2006-06-28

Applicant: Mary Freddo ,  Ki Keum ,  Naechoon Yoo ,  Won Yoo

Inventor： Mary Freddo ,  Ki Keum ,  Naechoon Yoo ,  Won Yoo

IPC: A61K31/728 ,  A61K33/00 ,  A61K33/42

CPC classification number: A61K33/00 ,  A61K31/728 ,  A61K45/06

Abstract: The present invention relates to methods and compositions for inhibiting scar formation on wound region. In certain embodiments, the methods include administering an alkalinization agent in combination with hyaluronic acid to a wound site to reduce the formation of scars at the wound site. Suitable alkalization agents include sodium bicarbonate, sodium hydroxide and potassium hydroxide.

Abstract translation: 本发明涉及用于抑制伤口区域上的瘢痕形成的方法和组合物。 在某些实施方案中，所述方法包括向伤口部位施用与透明质酸组合的碱化剂以减少伤口位置处的瘢痕形成。 合适的碱化剂包括碳酸氢钠，氢氧化钠和氢氧化钾。

公开(公告)号：US20070048391A1

公开(公告)日：2007-03-01

申请号：US11210619

申请日：2005-08-23

Applicant: Ki Keum ,  Naechoon Yoo ,  Won Yoo

Inventor： Ki Keum ,  Naechoon Yoo ,  Won Yoo

IPC: A61K31/728 ,  A61K33/00

CPC classification number: A61K31/728 ,  A61K33/00 ,  A61K45/06

Abstract: The present invention relates to a pharmaceutical composition for inhibiting scar formation on wound region which consists of hyaluronic acid and alkalization agent such as sodium bicarbonate, NaOH, and KOH.

Abstract translation: 本发明涉及用于抑制由透明质酸和碱化剂如碳酸氢钠，NaOH和KOH组成的伤口区域上的瘢痕形成的药物组合物。