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公开(公告)号：US20090305394A1
公开(公告)日：2009-12-10
申请号：US12160965
申请日：2007-01-18
申请人： Sang Yup Lee , So Young Yoo , Eung Kweon Kim , Ki-Chang Keum , Won-Min Yoo , Nae-Choon Yoo
发明人： Sang Yup Lee , So Young Yoo , Eung Kweon Kim , Ki-Chang Keum , Won-Min Yoo , Nae-Choon Yoo
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to oligonucleotides for diagnosis of corneal dystrophy. More particularly, the present invention relates to oligonucleotides for detecting mutation of BIGH3 gene for diagnosis or corneal dystrophy including Avellino corneal dystrophy, which must be precisely diagnosed before vision correction surgery, and a DNA chip for diagnosis of corneal dystrophy, which has the oligonucleotides fixed thereon. According to the present invention, conventional microscopic diagnosis of corneal dystrophy can be replaced with a precise genetic method, which prevents a patient with corneal dystrophy from losing eyesight by eyesight correction surgery after erroneous diagnosis.
摘要翻译： 本发明涉及用于诊断角膜营养不良的寡核苷酸。 更具体地，本发明涉及用于检测用于诊断或角膜营养不良的BIGH3基因的突变的寡核苷酸，其包括在视力矫正手术之前必须精确诊断的Avellino角膜营养不良，以及用于诊断角膜营养不良的DNA芯片，其具有固定的寡核苷酸 上。 根据本发明，可以用精确的遗传方法代替常规的角膜营养不良症的微观诊断，其可以防止角膜营养不良患者在错误诊断后通过视力矫正手术而失去视力。
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公开(公告)号：US20080193386A1
公开(公告)日：2008-08-14
申请号：US11909461
申请日：2006-03-24
申请人： Won-Min Yoo , Nae-Choon Yoo , Ki-Chang Keum , Sang-Yup Lee , Gene Lee
发明人： Won-Min Yoo , Nae-Choon Yoo , Ki-Chang Keum , Sang-Yup Lee , Gene Lee
摘要： The present invention relates to a composition for treating alopecia or promoting hair growth, which contains the blood plasma or serum as an active ingredient. The inventive composition is effective in hair growth, hair growth promotion and hair loss prevention.
摘要翻译： 本发明涉及一种治疗脱发或促进毛发生长的组合物，其含有血浆或血清作为活性成分。 本发明的组合物在毛发生长，促进毛发生长和脱发中是有效的。
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3.发明授权Compositions and methods for the treatment of wounds and the reduction of scar formation 失效用于治疗创伤和减少瘢痕形成的组合物和方法公开(公告)号：US07323184B2
公开(公告)日：2008-01-29
申请号：US11476543
申请日：2006-06-28
申请人： Mary Ellen Freddo , Ki Chang Keum , Naechoon Yoo , Won Min Yoo
发明人： Mary Ellen Freddo , Ki Chang Keum , Naechoon Yoo , Won Min Yoo
CPC分类号： A61K33/00 , A61K31/728 , A61K45/06
摘要： The present invention relates to methods and compositions for inhibiting scar formation on wound region. In certain embodiments, the methods include administering an alkalinization agent in combination with hyaluronic acid to a wound site to reduce the formation of scars at the wound site. Suitable alkalization agents include sodium bicarbonate, sodium hydroxide and potassium hydroxide.
摘要翻译： 本发明涉及用于抑制伤口区域上的瘢痕形成的方法和组合物。 在某些实施方案中，所述方法包括向伤口部位施用与透明质酸组合的碱化剂以减少伤口位置处的瘢痕形成。 合适的碱化剂包括碳酸氢钠，氢氧化钠和氢氧化钾。
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公开(公告)号：US07255883B2
公开(公告)日：2007-08-14
申请号：US10312097
申请日：2001-06-20
申请人： Ki Chang Keum , Naechoon Yoo , Won-min Yoo
发明人： Ki Chang Keum , Naechoon Yoo , Won-min Yoo
CPC分类号： A61K33/00
摘要： The present invention relates to an agent for reducing scar formation, which inhibits the scar formation by injecting sodium bicarbonate to the dermis tissue of the wound with a syringe to directly control pH of the wound site, namely, by alkalinizing the wound to inactivate TGF-β. According to the present invention, the agent for reducing scar formation by controlling the wound healing process can be clinically and immediately applied to the treatment of tylosis scar and keloid, etc., and is effective to the treatment of intractable fibrosis diseases. Also, the invention can be widely applied in many ways as an easy tool which can control the action of TGF-β in a living organism.
摘要翻译： 本发明涉及一种用于减少瘢痕形成的药剂，其通过用注射器将碳酸氢钠注入伤口的真皮组织来抑制瘢痕形成，以直接控制伤口部位的pH，即通过使伤口碱化以使TGF- 测试版 根据本发明，通过控制伤口愈合过程来减少瘢痕形成的药剂可以临床上立即应用于治疗泰乐菌瘢痕和瘢痕疙瘩等，对于治疗难治性纤维化疾病是有效的。 此外，本发明可以以许多方式广泛应用，作为可以控制活体中TGF-β的作用的简单工具。
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5.发明申请METHOD OF DIAGNOSING CANCER USING G-CSF PROTEIN HAVING A DELETION OF AN AMINO ACID SEQUENCE CORRESPONDING TO EXON 3 AS A DIAGNOSTIC CANCER MARKER 审中-公开使用具有与作为诊断性癌症标记的外显子3相关的氨基酸序列的G-CSF蛋白质诊断癌症的方法公开(公告)号：US20120329078A1
公开(公告)日：2012-12-27
申请号：US13546966
申请日：2012-07-11
申请人： SANG YUP LEE , NAE CHOON YOO , SO YOUNG YOO , HYUN CHEOL CHUNG , KI CHANG KEUM , WON MIN YOO , KI JUN JEONG
发明人： SANG YUP LEE , NAE CHOON YOO , SO YOUNG YOO , HYUN CHEOL CHUNG , KI CHANG KEUM , WON MIN YOO , KI JUN JEONG
IPC分类号： G01N33/574
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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6.发明授权公开(公告)号：US08324363B2
公开(公告)日：2012-12-04
申请号：US11058976
申请日：2005-02-16
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07H21/04 , C12Q1/68 , C07K14/535
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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公开(公告)号：US08017157B2
公开(公告)日：2011-09-13
申请号：US11638056
申请日：2006-12-12
申请人： Won Min Yoo , Kyung Hee Chang , Nae Choon Yoo , Ki Chang Keum , Sang Yup Lee , Gene Lee
发明人： Won Min Yoo , Kyung Hee Chang , Nae Choon Yoo , Ki Chang Keum , Sang Yup Lee , Gene Lee
IPC分类号： A61K35/16
CPC分类号： A61K35/16
摘要： The present invention relates to a pharmaceutical composition for the treatment of wounds containing blood plasma or serum and a method for treating wounds effectively by applying said composition to the wound site to normalize the tissue-environment around the site.
摘要翻译： 本发明涉及用于治疗含有血浆或血清的伤口的药物组合物和通过将所述组合物施用于伤口部位来有效地治疗伤口的方法，以使得围绕该部位周围的组织环境归一化。
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公开(公告)号：US20100167951A1
公开(公告)日：2010-07-01
申请号：US12522392
申请日：2007-01-08
申请人： Sang Yup Lee , Seung Min Yoo , Ki-Chang Keum , Nae-Choon Yoo , Won-Min Yoo , June-Myung Kim , Jun Yong Choi
发明人： Sang Yup Lee , Seung Min Yoo , Ki-Chang Keum , Nae-Choon Yoo , Won-Min Yoo , June-Myung Kim , Jun Yong Choi
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： The present invention relates to nucleic acid probes specific to Staphylococcus aureus, which is useful for detecting and identifying S. aureus in a biological sample. More particularly, the present invention relates to a DNA chip for detecting and identifying S. aureus, on which nucleic acid probes derived from 23 S rRNA gene of S. aureus are immobilized. The application of the DNA chips according to the present invention allows time-saving and accurate diagnosis of bacterial infection compared with the conventional bacterial culture methods.
摘要翻译： 本发明涉及对金黄色葡萄球菌特异性的核酸探针，其可用于检测和鉴定生物样品中的金黄色葡萄球菌。 更具体地，本发明涉及用于检测和鉴定金黄色葡萄球菌的DNA芯片，其上固定有金黄色葡萄球菌23S rRNA基因的核酸探针。 与常规细菌培养方法相比，根据本发明的DNA芯片的应用允许节省细菌感染的准确诊断。
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9.发明申请G-CSF PROTEIN HAVING A DELETION OF AN AMINO ACID SEQUENCE CORRESPONDING TO EXON 3 FOR USE AS A DIAGNOSTIC CANCER MARKER 审中-公开具有相关性的氨基酸序列的G-CSF蛋白3用作诊断性癌症标记公开(公告)号：US20120322684A1
公开(公告)日：2012-12-20
申请号：US13546972
申请日：2012-07-11
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07K14/535 , C12Q1/68 , C40B30/04 , C07H21/04
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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10.发明申请DIAGNOSTIC METHOD FOR CANCER CHARACTERIZED IN THE DETECTION OF THE DELETION OF G-CSF EXON 3 审中-公开检测G-CSF外显子3检测中的癌症诊断方法公开(公告)号：US20100286381A1
公开(公告)日：2010-11-11
申请号：US12830085
申请日：2010-07-02
申请人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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