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    Process for the preparation of oxcarbazepine
    2.
    发明授权
    Process for the preparation of oxcarbazepine 有权
    奥卡西平制备方法

    公开(公告)号：US08530647B2

    公开(公告)日：2013-09-10

    申请号：US12991600

    申请日：2009-05-06

    申请人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

    发明人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

    IPC分类号： C07D223/26

    CPC分类号： C07D223/22

    摘要： The present invention relates to an improved process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of α-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine.

    摘要翻译： 本发明涉及通过使10-甲氧基-5H-二苯并[b，f]咔唑反应制备10-氧代-10,11-二氢-5H-二苯并[b，f]吖庚因-5-甲酰胺（奥卡西平） f]吖庚因（10-甲氧基亚氨基芪）和碱金属氰酸酯，还涉及从亚氨基茋制备卡马西平的方法。 此外，本发明涉及10-甲氧基卡马西平的新结晶形式。

    CARVEDILOL PHOSPHATE SESQUIHYDRATE
    3.
    发明申请
    CARVEDILOL PHOSPHATE SESQUIHYDRATE 有权
    CARVEDILOL磷酸盐水溶液

    公开(公告)号：US20090259051A1

    公开(公告)日：2009-10-15

    申请号：US12304645

    申请日：2007-06-11

    申请人： Seeta Ramanjaneyulu Gorantla ,  Mohan Bandari ,  Nageswara Rao Karusala ,  Sankara Sastry Tummalapalli

    发明人： Seeta Ramanjaneyulu Gorantla ,  Mohan Bandari ,  Nageswara Rao Karusala ,  Sankara Sastry Tummalapalli

    IPC分类号： C07D209/82 ,  A61P9/12

    CPC分类号： C07D209/88

    摘要： The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate), methods of preparing the sesquihydrate by adding phosphoric acid to a suspension of Carvedilol in water, water miscible solvents or a mixture of water and water miscible organic solvent followed by isolating the product directly or by adding solvent.

    摘要翻译： 本发明涉及一种新的1-（恶唑-4-基氧基-3 - [[2-（邻甲氧基苯氧基）乙基]氨基] -2-丙醇磷酸倍半水合物（卡维地洛二氢磷酸倍半水合物）的结晶，通过加入制备倍半水合物的方法 磷酸与卡维地洛在水中的混悬液，水溶性溶剂或水与水混溶的有机溶剂的混合物，然后直接或通过加入溶剂分离产物。

    PROCESS FOR THE PREPARATION OF OXCARBAZEPINE
    6.
    发明申请
    PROCESS FOR THE PREPARATION OF OXCARBAZEPINE 有权
    制备奥沙拉贝的方法

    公开(公告)号：US20110065917A1

    公开(公告)日：2011-03-17

    申请号：US12991600

    申请日：2009-05-06

    申请人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

    发明人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

    IPC分类号： C07D223/18

    CPC分类号： C07D223/22

    摘要： The present invention relates to an improved process for the preparation of 10-oxo-10,11-dihydiO-5H-dibenz[b,fjazepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of α-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine.

    摘要翻译： 本发明涉及通过使10-甲氧基-5H-二苯并[b，f]喹唑啉反应制备10-氧代-10,11-二氢-5H-二苯并[b，fjazepine-5-甲酰胺（奥卡西平） 吖庚因（10-甲氧基亚氨基芪）和碱金属氰酸盐存在的α-羟基酸，也涉及从亚氨基茋制备卡马西平的方法。 此外，本发明涉及10-甲氧基卡马西平的新结晶形式。