公开(公告)号：US20110065917A1

公开(公告)日：2011-03-17

申请号：US12991600

申请日：2009-05-06

申请人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

发明人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

IPC分类号： C07D223/18

CPC分类号： C07D223/22

摘要： The present invention relates to an improved process for the preparation of 10-oxo-10,11-dihydiO-5H-dibenz[b,fjazepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of α-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine.

摘要翻译： 本发明涉及通过使10-甲氧基-5H-二苯并[b，f]喹唑啉反应制备10-氧代-10,11-二氢-5H-二苯并[b，fjazepine-5-甲酰胺（奥卡西平） 吖庚因（10-甲氧基亚氨基芪）和碱金属氰酸盐存在的α-羟基酸，也涉及从亚氨基茋制备卡马西平的方法。 此外，本发明涉及10-甲氧基卡马西平的新结晶形式。

公开(公告)号：US08530647B2

公开(公告)日：2013-09-10

申请号：US12991600

申请日：2009-05-06

申请人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

发明人： Nageswara Rao Karusala ,  Uma Sankara Sastry Tummalapally ,  Appi Reddy Talatala ,  Debashish Datta

IPC分类号： C07D223/26

CPC分类号： C07D223/22

摘要： The present invention relates to an improved process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of α-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine.

摘要翻译： 本发明涉及通过使10-甲氧基-5H-二苯并[b，f]咔唑反应制备10-氧代-10,11-二氢-5H-二苯并[b，f]吖庚因-5-甲酰胺（奥卡西平） f]吖庚因（10-甲氧基亚氨基芪）和碱金属氰酸酯，还涉及从亚氨基茋制备卡马西平的方法。 此外，本发明涉及10-甲氧基卡马西平的新结晶形式。