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    Method for screening of patient to be administered with pharmaceutical agent comprising anti-cancer antibody as active ingredient
    1.
    发明授权
    Method for screening of patient to be administered with pharmaceutical agent comprising anti-cancer antibody as active ingredient 有权
    用于筛选给予包含抗癌抗体作为活性成分的药剂的患者的方法

    公开(公告)号：US08642032B2

    公开(公告)日：2014-02-04

    申请号：US12666716

    申请日：2008-06-26

    申请人： Takashi Sato ,  Naoya Kimoto ,  Yuji Ohki ,  Akiko Furuya ,  Hiroyuki Ishida ,  Atsushi Ochiai

    发明人： Takashi Sato ,  Naoya Kimoto ,  Yuji Ohki ,  Akiko Furuya ,  Hiroyuki Ishida ,  Atsushi Ochiai

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/57488 ,  A61K2039/505 ,  C07K16/28 ,  G01N2800/52

    摘要： The present invention provides a method for screening a patient to be administered with a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient, said method comprising collecting samples from patients who expresses an antigen which is recognized by the anti-cancer antibody, measuring cadherin function in the samples, and selecting a patient whose the cadherin function is decreased or deleted; a method for screening a patient who has a high efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient; and a method for improving an efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient.

    摘要翻译： 本发明提供一种用于筛选待给药的患者的方法，所述药物组合物包含抗癌抗体作为活性成分，所述方法包括从表达抗原的患者中收集由抗癌抗体识别的抗原的样品， 测定样品中的钙粘蛋白功能，选择其钙粘蛋白功能减少或缺失的患者; 一种用于筛选具有高效率比的药物组合物的方法，所述药物组合物包含抗癌抗体作为活性成分; 以及提高作为有效成分的抗癌抗体的药物组合物的功效比的方法。

    METHOD FOR SCREENING OF PATIENT TO BE ADMINISTERED WITH PHARMACEUTICAL AGENT COMPRISING ANTI-CANCER ANTIBODY AS ACTIVE INGREDIENT
    2.
    发明申请
    METHOD FOR SCREENING OF PATIENT TO BE ADMINISTERED WITH PHARMACEUTICAL AGENT COMPRISING ANTI-CANCER ANTIBODY AS ACTIVE INGREDIENT 有权
    用作为活性成分包含抗癌抗体的药物代理进行筛选的患者筛选方法

    公开(公告)号：US20100189724A1

    公开(公告)日：2010-07-29

    申请号：US12666716

    申请日：2008-06-26

    申请人： Takashi Sato ,  Naoya Kimoto ,  Yuji Ohki ,  Akiko Furuya ,  Hiroyuki Ishida ,  Atsushi Ochian

    发明人： Takashi Sato ,  Naoya Kimoto ,  Yuji Ohki ,  Akiko Furuya ,  Hiroyuki Ishida ,  Atsushi Ochian

    IPC分类号： A61K39/395 ,  G01N33/68 ,  A61P35/00

    CPC分类号： G01N33/57488 ,  A61K2039/505 ,  C07K16/28 ,  G01N2800/52

    摘要： The present invention provides a method for screening a patient to be administered with a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient, said method comprising collecting samples from patients who expresses an antigen which is recognized by the anti-cancer antibody, measuring cadherin function in the samples, and selecting a patient whose the cadherin function is decreased or deleted; a method for screening a patient who has a high efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient; and a method for improving an efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient.

    摘要翻译： 本发明提供一种用于筛选待给药的患者的方法，所述药物组合物包含抗癌抗体作为活性成分，所述方法包括从表达抗原的患者中收集由抗癌抗体识别的抗原的样品， 测定样品中的钙粘蛋白功能，选择其钙粘蛋白功能减少或缺失的患者; 一种用于筛选具有高效率比的药物组合物的方法，所述药物组合物包含抗癌抗体作为活性成分; 以及提高作为有效成分的抗癌抗体的药物组合物的功效比的方法。