-
1.发明授权Mutated HOXB4 proteins with improved stability, and methods of use thereof 有权具有改善的稳定性的突变的HOXB4蛋白及其使用方法公开(公告)号：US08039436B2
公开(公告)日：2011-10-18
申请号：US12129919
申请日：2008-05-30
CPC分类号： C07K14/47 , A61K38/00 , G01N33/6872
摘要： A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.
摘要翻译： 一种多肽，其氨基酸序列包含SEQ ID NO：2所示的序列，包括在序列的第1和35位之间包含的多肽的退链结构域内的至少一个突变，其中所述至少一个突变 降低多肽对泛素 - 蛋白酶体降解的敏感性。
-
2.发明申请MUTATED HOXB4 PROTEINS WITH IMPROVED STABILITY, AND METHODS OF USE THEREOF 有权具有改善稳定性的突变型HOXB4蛋白及其使用方法公开(公告)号：US20080300187A1
公开(公告)日：2008-12-04
申请号：US12129919
申请日：2008-05-30
IPC分类号： A61K38/17 , C07K14/47 , C07K19/00 , C07K16/18 , C07H21/04 , G01N33/68 , C12P21/02 , C12N15/63 , C12N5/10 , C12N5/06
CPC分类号： C07K14/47 , A61K38/00 , G01N33/6872
摘要： A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.
摘要翻译： 一种多肽，其氨基酸序列包含SEQ ID NO：2所示的序列，包括在序列的第1和35位之间包含的多肽的退链结构域内的至少一个突变，其中所述至少一个突变 降低多肽对泛素 - 蛋白酶体降解的敏感性。
-
搜索结果
2 条记录 (耗时 0.012 秒)
