公开(公告)号：US20060263792A1

公开(公告)日：2006-11-23

申请号：US11263569

申请日：2005-10-31

Applicant: Nehal Mohamed ,  George Spitalny ,  Leslie Casey ,  Steven Jones ,  Steven Pincus

Inventor： Nehal Mohamed ,  George Spitalny ,  Leslie Casey ,  Steven Jones ,  Steven Pincus

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: C07K16/2896

Abstract: The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effecting clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which binds specifically to complement receptor 1 (CR1) and does not substantially bind to complement receptor 2 (CR2), linked to a second moiety which comprises the antigen or binds to the antigen. Methods of producing such molecules and their therapeutic and/or prophylactic uses are also featured.

Abstract translation: 本发明提供了与能够既诱导对哺乳动物的抗原的免疫应答的分子的发现相关的方法和组合物，并且还能够实现抗原的清除，其中这些分子包含第一部分，其包含特异性结合于 补体受体1（CR1），并且基本上不与补体受体2（CR2）结合，其与包含抗原或与抗原结合的第二部分连接。 还提出了生产这种分子的方法及其治疗和/或预防用途。

公开(公告)号：US20050031625A1

公开(公告)日：2005-02-10

申请号：US10812636

申请日：2004-03-29

Applicant: Nehal Mohamed ,  George Spitalny ,  Leslie Casey

Inventor： Nehal Mohamed ,  George Spitalny ,  Leslie Casey

IPC: A61K47/48 ,  A61P31/04 ,  A61P31/12 ,  C07K16/12 ,  C07K16/28 ,  A61K39/40 ,  C07K16/46

CPC classification number: C07K16/2896 ,  A61K47/6849 ,  A61K47/6879 ,  A61K2039/505 ,  C07K16/1271 ,  C07K16/1278 ,  C07K2317/31

Abstract: The present invention provide a bispecific molecule comprising an antibody that binds a C3b-like receptor linked to one or more non-neutralizing antigen-binding antibodies or fragments thereof. The present invention also provides methods to identify non-neutralizing antibodies, and particularly, to identify enhancing antibodies. Methods of producing such bispecific molecules and their therapeutic and/or prophylactic uses are also provided by the present invention

Abstract translation: 本发明提供了包含结合与一种或多种非中和抗原结合抗体或其片段连接的C3b样受体的抗体的双特异性分子。 本发明还提供鉴定非中和抗体的方法，特别是鉴定增强抗体。 本发明还提供了生产这种双特异性分子的方法及其治疗和/或预防用途

公开(公告)号：US20060153839A1

公开(公告)日：2006-07-13

申请号：US10527936

申请日：2003-09-16

Applicant: Nehal Mohamed ,  Leslie Casey ,  James Porter ,  Xiaoliang Wang ,  Muctarr Sesay ,  Lihsyng Lee

Inventor： Nehal Mohamed ,  Leslie Casey ,  James Porter ,  Xiaoliang Wang ,  Muctarr Sesay ,  Lihsyng Lee

IPC: A61K39/40 ,  C07K16/12

CPC classification number: C07K16/1278 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622

Abstract: The invention relates to a bispecific molecule comprising a first recognition binding moeity that binds a Cab-like receptor cross-linked using a poly-(ethylene glycol) (“PEG”) linker with one or more second recognition binding moieties that bind a molecule. The invention also relates to methods of producing such bispecific molecules and to therapeutic uses of such bispecific molecules.

Abstract translation: 本发明涉及双特异性分子，其包含结合使用聚（乙二醇）（“PEG”）连接体与结合分子的一个或多个第二识别结合部分交联的Cab样受体的第一识别结合力。 本发明还涉及产生这种双特异性分子的方法和这种双特异性分子的治疗用途。

公开(公告)号：US20060140931A1

公开(公告)日：2006-06-29

申请号：US10527937

申请日：2003-09-16

Applicant: Nehal Mohamed ,  Leslie Casey ,  James Porter ,  Xiaoliang Wang ,  Muctarr Sesay

Inventor： Nehal Mohamed ,  Leslie Casey ,  James Porter ,  Xiaoliang Wang ,  Muctarr Sesay

IPC: A61K39/395 ,  C07K16/28

CPC classification number: C07K16/2896 ,  A61K2039/505 ,  C07K16/1278 ,  C07K2317/31 ,  C07K2317/55

Abstract: The invention provides a bispecific molecule comprising an antibody that binds a C3b-like to one or more antigen-binding antibody fragments, each of which binds an antigenic molecule. The invention also provides methods of producing such bispecific molecules and to therapeutic uses of such bispecific molecules. The invention further provides bispecific molecules in which the antigen-binding antibody fragment binds the protective antigen protein of Bacillus anthracis (Anthrax) exotoxin for treatment of Anthrax infection.

Abstract translation: 本发明提供了包含将C3b样结合至一个或多个抗原结合抗体片段的抗体的双特异性分子，每个抗体结合抗体片段均结合抗原分子。 本发明还提供了产生这种双特异性分子的方法和这种双特异性分子的治疗用途。 本发明还提供双特异性分子，其中抗原结合抗体片段与炭疽芽孢杆菌（炭疽）外毒素的保护性抗原蛋白结合，用于治疗炭疽感染。