公开(公告)号：US12065486B2

公开(公告)日：2024-08-20

申请号：US17221177

申请日：2021-04-02

申请人： TRUSTEES OF TUFTS COLLEGE

发明人： Charles B. Shoemaker

IPC分类号： A61K39/00 ,  C07K16/12

CPC分类号： C07K16/1282 ,  C07K16/1278 ,  C12Y304/24069 ,  C12Y304/24083 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/76 ,  G01N2333/952 ,  G01N2333/954

摘要： Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a Botulinum toxin or an Anthrax toxin.

公开(公告)号：US12011000B2

公开(公告)日：2024-06-18

申请号：US18346437

申请日：2023-07-03

申请人： IMPETUS AGRICULTURE, INC.

发明人： Heba Mohamed Yassen Abdelgaffar ,  Constanze Hahnfeld ,  Juan Luis Jurat-Fuentes ,  Erik Jongedijk ,  Jeffrey M. Staub ,  Stefan Meldau

IPC分类号： A01N63/50 ,  A01P7/04 ,  C07K14/325 ,  C07K16/12 ,  C07K16/28

CPC分类号： A01N63/50 ,  A01P7/04 ,  C07K14/325 ,  C07K16/1278 ,  C07K16/28 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2319/55

摘要： Affinity constructs and affinity molecules to direct insecticidal toxins to insect specific structures of target insects are presented herein. The affinity constructs comprise of at least one affinity molecule that is capable of recognizing, or capable of binding to, or binding to, or being directed to, or being designed to bind to an insect-specific structure in and/or on a target insect, and at least one other affinity molecule capable of binding to, or binding to, or being directed to, or being designed to bind to an insecticidal protein (toxin) wherein the at least two affinity molecules are operably coupled. Presented herein are also methods of making and using these affinity constructs and affinity molecules.

公开(公告)号：US20240041049A1

公开(公告)日：2024-02-08

申请号：US18346437

申请日：2023-07-03

申请人： IMPETUS AGRICULTURE, INC.

发明人： Heba Mohamed Yassen ABDELGAFFAR ,  Constanze HAHNFELD ,  Juan Luis JURAT-FUENTES ,  Erik JONGEDIJK ,  JEFFREY M. STAUB ,  Stefan MELDAU

IPC分类号： A01N63/50 ,  C07K16/28 ,  C07K16/12 ,  C07K14/325 ,  A01P7/04

CPC分类号： A01N63/50 ,  C07K16/28 ,  C07K16/1278 ,  C07K14/325 ,  A01P7/04 ,  C07K2317/569 ,  C07K2319/55 ,  C07K2317/31 ,  C07K2317/92

摘要： Affinity constructs and affinity molecules to direct insecticidal toxins to insect specific structures of target insects are presented herein. The affinity constructs comprise of at least one affinity molecule that is capable of recognizing, or capable of binding to, or binding to, or being directed to, or being designed to bind to an insect-specific structure in and/or on a target insect, and at least one other affinity molecule capable of binding to, or binding to, or being directed to, or being designed to bind to an insecticidal protein (toxin) wherein the at least two affinity molecules are operably coupled. Presented herein are also methods of making and using these affinity constructs and affinity molecules.

公开(公告)号：US11841366B2

公开(公告)日：2023-12-12

申请号：US16821170

申请日：2020-03-17

申请人： Syngenta Participations AG

发明人： Simone Cummings ,  Julie Smith ,  Magda Foege

IPC分类号： G01N33/543 ,  G01N33/577 ,  C07K16/12 ,  G01N33/58

CPC分类号： G01N33/54393 ,  C07K16/1278 ,  G01N33/577 ,  G01N33/581 ,  G01N2333/325

摘要： The invention relates generally to immunoassays, and more particularly to monoclonal antibodies and immunoassays for the differential detection and quantitation of a wild-type crystal protein, such as a wild-type-Cry1Ab, from Bacillus thuringiensis and hybrid crystal proteins, which comprise all or a significant portion of the wild-type Cry protein in complex biological samples comprising both the wild-type Cry protein and one or more of the hybrid Cry proteins.

公开(公告)号：US20190247497A1

公开(公告)日：2019-08-15

申请号：US16299398

申请日：2019-03-12

申请人： Eli Lilly and Company ,  Zymeworks Inc.

发明人： Yiwen LI ,  Dale Lincoln LUDWIG ,  Yang SHEN ,  Yi ZHANG ,  Igor Edmondo Paolo D'ANGELO

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  C07K16/12 ,  C07K16/26 ,  C07K16/36 ,  C07K16/46 ,  C12P21/00 ,  A61P35/00 ,  A61K39/40 ,  A61K9/00

CPC分类号： A61K39/3955 ,  A61K9/0019 ,  A61K31/351 ,  A61K31/4164 ,  A61K33/24 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  A61P35/00 ,  C07K16/1278 ,  C07K16/1282 ,  C07K16/26 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/283 ,  C07K16/2866 ,  C07K16/2896 ,  C07K16/36 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C12P21/005

摘要： The present invention relates to antibodies that are heterodimeric and bind human PD-L1 and human TIM-3, and may be useful for treating cancer alone and in combination with chemotherapy and other cancer therapeutics.

公开(公告)号：US09995746B2

公开(公告)日：2018-06-12

申请号：US15125910

申请日：2014-04-02

申请人： The United States of America as represented by the Secretary of the Army

发明人： Teresa Abshire ,  Wilson J Ribot

IPC分类号： A61K38/00 ,  G01N33/569 ,  C07K16/12 ,  C07K16/44

CPC分类号： G01N33/56911 ,  C07K16/1278 ,  C07K16/44 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/70 ,  G01N2333/32 ,  G01N2469/10

摘要： In this application is described a method for rapidly and accurately identifying B. anthracis in a sample by simultaneously detecting the presence of cell wall antigen and capsule antigen in the same sample culture grown under capsule inducing conditions. Other uses and advantages of the method of the invention are described herein.

公开(公告)号：US09861707B2

公开(公告)日：2018-01-09

申请号：US15376459

申请日：2016-12-12

申请人： Purdue Research Foundation

发明人： Ruben Claudio Aguilar ,  Timothy Ratliff ,  David Thompson ,  Scott Crist

IPC分类号： A61K38/16 ,  A61K47/48 ,  A61K47/64 ,  A61K47/68 ,  A61K47/69

CPC分类号： A61K38/164 ,  A61K47/64 ,  A61K47/6835 ,  A61K47/6881 ,  A61K47/6913 ,  A61K47/6927 ,  A61K2039/505 ,  C07K16/12 ,  C07K16/1278 ,  C07K16/28 ,  C07K16/3038

摘要： Composition and methods are disclosed for utilizing microaggregation of FAP-containing complexes to promote their fast internalization. This approach allows the uptake of cytotoxic cargo coupled to either FAP-Antibodies or FAP-liposome complexes by tumor bladder cells. Importantly, this approach is efficient even under serum-free conditions such as the ones found in the lumen of the bladder.

公开(公告)号：US09845349B2

公开(公告)日：2017-12-19

申请号：US14694627

申请日：2015-04-23

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Jason Marc Goldstein ,  Conrad P. Quinn ,  Dennis A. Bagarozzi, Jr.

IPC分类号： C07K16/12 ,  C07K7/00

CPC分类号： C07K16/1278 ,  C07K7/00 ,  C07K2317/34 ,  C07K2317/75

摘要： Provided are antibodies capable of binding to a particular epitope or specifically binding to LF or LTx and enhancing the activity of the LF or LTx relative to the LF or LTx absent the antibody binding.

公开(公告)号：US09770038B2

公开(公告)日：2017-09-26

申请号：US15104127

申请日：2015-01-09

申请人： JIANGSU ACADEMY OF AGRICULTURAL SCIENCES

发明人： Xianjin Liu ,  Chongxin Xu ,  Xiao Zhang ,  Yuan Liu ,  Yajing Xie ,  Cunzheng Zhang ,  Xiangyang Yu ,  Donglan Wang

IPC分类号： A01N63/02 ,  C07K16/12 ,  C12N15/70

CPC分类号： A01N63/02 ,  C07K16/12 ,  C07K16/1278 ,  C07K2317/622 ,  C12N15/70

摘要： Provided are a human-derived insect-resistant gene having a nucleotide sequence represented by SEQ ID NO.1, and an anti-Cry1B toxin idiotype single-chain antibody encoded by said human-derived insect-resistant gene and having an amino acid sequence represented by SEQ ID NO.2. The idiotype single-chain antibody is a β-type and has insecticidal activity, and after expression by the prokaryotic system, the primary culture thereof has binding activity to Cnaphalocrocis medinalis midgut peritrophic membrane specific receptor BBMV.

公开(公告)号：US20170101447A1

公开(公告)日：2017-04-13

申请号：US15384581

申请日：2016-12-20

申请人： Athenix Corporation

发明人： Kimberly S. Sampson ,  Daniel J. Tomso

IPC分类号： C07K14/325 ,  A01N37/18 ,  C12N15/82

CPC分类号： C07K14/325 ,  A01N37/18 ,  C07K16/1278 ,  C12N15/8286 ,  Y02A40/162

摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:61-121 and 133-141, or the nucleotide sequence set forth in SEQ ID NO:1-60, 124-132, and 142-283, as well as variants and fragments thereof.