公开(公告)号：US20080045715A1

公开(公告)日：2008-02-21

申请号：US11628210

申请日：2005-09-14

Applicant: Melville Mitchell ,  Neil Thomson ,  George Wilson ,  Neil Goodwin ,  Maureen Young

Inventor： Melville Mitchell ,  Neil Thomson ,  George Wilson ,  Neil Goodwin ,  Maureen Young

IPC: C07D489/08 ,  C07D221/18 ,  C07D221/28 ,  C07D489/02

CPC classification number: C07D489/02 ,  C07D221/28 ,  C07D489/08 ,  Y02P20/55

Abstract: A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CH3 or a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH3)OH, C(CH3)(C(CH3)3)OH or COCH3; Z is C2-C10 alkyl or C2-C10 arylalkyl; and ′ is a single bond or a double bond, is disclosed. The process is a reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.

Abstract translation: 制备式（A），（B）或（C）的化合物的方法：其中P是H，CH 3或羟基保护基; X是O，受保护的酮，OH，被保护的羟基或H; Y是OH，被保护的羟基或H; W是C（CH 3 CH 3）OH，C（CH 3）3（C（CH 3）3） OH或COCH 3; Z是C 2 -C 10烷基或C 2 -C 10芳基烷基; 并且是单债券或双重债券。 该方法是在氢和还原性烷基化催化剂存在下还原烷基化。

公开(公告)号：US20050171361A1

公开(公告)日：2005-08-04

申请号：US10503082

申请日：2003-02-03

Applicant: Neil Goodwin ,  Nicolas Archer ,  Christopher Murray ,  Alan Greenwood ,  Derek Mchattie

Inventor： Neil Goodwin ,  Nicolas Archer ,  Christopher Murray ,  Alan Greenwood ,  Derek Mchattie

IPC: A61K31/352 ,  A61K36/00 ,  A61K36/18 ,  A61P1/08 ,  B01D11/02 ,  C07D311/80 ,  C07D311/82

CPC classification number: C07D311/80 ,  A61K36/00 ,  A61K36/185 ,  Y10T436/142222 ,  Y10T436/25375 ,  Y10T436/255 ,  A61K2300/00

Abstract: Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is t5en converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.

Abstract translation: Delta9 THC酸从植物材料获得，并在pH控制条件下萃取到含水溶剂中。 将酸转化成盐，将盐萃取到极性溶剂中，产生高纯度的酸。 将Delta9THC酸转化为Delta9 THC，进一步纯化并与用于药物用途的载体组合。

公开(公告)号：US20050049298A1

公开(公告)日：2005-03-03

申请号：US10902698

申请日：2004-07-30

Applicant: Neil Goodwin ,  Nicolas Archer ,  Christopher Murray ,  Alan Greenwood ,  Derek Mchattie

Inventor： Neil Goodwin ,  Nicolas Archer ,  Christopher Murray ,  Alan Greenwood ,  Derek Mchattie

IPC: A61K31/352 ,  A61K36/00 ,  A61K36/18 ,  A61P1/08 ,  B01D11/02 ,  C07D311/80 ,  A61K31/353

CPC classification number: C07D311/80 ,  A61K36/00 ,  A61K36/185 ,  Y10T436/142222 ,  Y10T436/25375 ,  Y10T436/255 ,  A61K2300/00

Abstract: Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is t5hen converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.

Abstract translation: Delta9 THC酸从植物材料获得，并在pH控制条件下萃取到含水溶剂中。 将酸转化成盐，将盐萃取到极性溶剂中，产生高纯度的酸。 Delta9 THC酸被转化为Delta9 THC，进一步纯化并与用于药物用途的载体组合。