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Patent Agency Ranking
1.发明授权Targeted binding agents directed to sonic hedgehog homolog and uses thereof 失效针对声音刺猬蛋白同源物的靶向结合剂及其用途公开(公告)号：US08569459B2
公开(公告)日：2013-10-29
申请号：US13478580
申请日：2012-05-23
Applicant: David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
Inventor： David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.
Abstract translation: 本发明涉及针对人类声波刺猬蛋白同源物（Shh）的靶向结合剂及其用途。 更具体地，本发明涉及针对Shh的完全人单克隆抗体。 所描述的靶向结合剂可用于治疗与Shh的活性和/或过量产生相关的疾病和作为诊断。
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2.发明申请TARGETED BINDING AGENTS DIRECTED TO SONIC HEDGEHOG HOMOLOG AND USES THEREOF 失效针对SONIC HEDGEHOG HOMOLOG的针对性绑定代理及其用途公开(公告)号：US20120328625A1
公开(公告)日：2012-12-27
申请号：US13478580
申请日：2012-05-23
Applicant: David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
Inventor： David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
IPC: C07K16/18 , A61K39/395 , A61P35/00 , C12N15/13
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.
Abstract translation: 本发明涉及针对人类声波刺猬蛋白同源物（Shh）的靶向结合剂及其用途。 更具体地，本发明涉及针对Shh的完全人单克隆抗体。 所描述的靶向结合剂可用于治疗与Shh的活性和/或过量产生相关的疾病和作为诊断。
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3.发明申请TARGETED BINDING AGENTS DIRECTED TO SONIC HEDGEHOG HOMOLOG AND USES THEREOF 失效针对SONIC HEDGEHOG HOMOLOG的针对性绑定代理及其用途公开(公告)号：US20100196388A1
公开(公告)日：2010-08-05
申请号：US12562435
申请日：2009-09-18
Applicant: David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
Inventor： David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
IPC: A61K39/395 , C07K16/18 , C07H21/04 , A61P35/00
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.
Abstract translation: 本发明涉及针对人类声波刺猬蛋白同源物（Shh）的靶向结合剂及其用途。 更具体地，本发明涉及针对Shh的完全人单克隆抗体。 所描述的靶向结合剂可用于治疗与Shh的活性和/或过量产生相关的疾病和作为诊断。
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公开(公告)号：US20050054019A1
公开(公告)日：2005-03-10
申请号：US10910901
申请日：2004-08-03
Applicant: Neil Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry Green , Xiao-Chi Jia
Inventor： Neil Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry Green , Xiao-Chi Jia
IPC: A61K39/395 , A61P17/00 , A61P35/00 , C07K16/28 , C07K16/30 , C07K16/44 , C12N15/13 , G01N33/574
CPC classification number: A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
Abstract translation: 本发明涉及特异性结合c-Met，优选人c-Met的人抗体及其抗原结合部分的抗体，其功能是抑制c-Met。 本发明还涉及人抗c-Met抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗c-Met抗体的方法，包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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5.发明授权Targeted binding agents directed to sonic hedgehog homolog and uses thereof 失效针对声音刺猬蛋白同源物的靶向结合剂及其用途公开(公告)号：US08207306B2
公开(公告)日：2012-06-26
申请号：US12562435
申请日：2009-09-18
Applicant: David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
Inventor： David Jenkins , Neil Michaud , Naomi Laing , Jaspal Singh Kang
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.
Abstract translation: 本发明涉及针对人类声波刺猬蛋白同源物（Shh）的靶向结合剂及其用途。 更具体地，本发明涉及针对Shh的完全人单克隆抗体。 所描述的靶向结合剂可用于治疗与Shh的活性和/或过量产生相关的疾病和作为诊断。
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