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公开(公告)号:US20050048552A1
公开(公告)日:2005-03-03
申请号:US10909914
申请日:2004-08-02
申请人: David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
发明人: David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
CPC分类号: C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N2310/15 , C12N2310/3181 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要: Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译: 肽核酸和肽核酸的类似物用于与核酸形成双链体,三链体和其他结构并修饰核酸。 肽核酸及其类似物也用于通过例如核酸的转录停止,转录起始和位点特异性切割来调节蛋白质活性。