公开(公告)号：US07572642B2

公开(公告)日：2009-08-11

申请号：US10125102

申请日：2002-04-17

申请人： Nigel G. Skinner ,  Paul Fenton ,  George A. Adaniya

发明人： Nigel G. Skinner ,  Paul Fenton ,  George A. Adaniya

IPC分类号： G01N33/543

CPC分类号： G01N33/54346 ,  C12Q1/6827 ,  C12Q1/6874 ,  G01N33/54373 ,  Y10T428/2982 ,  Y10T436/13 ,  C12Q2565/501 ,  C12Q2563/185 ,  C12Q2563/149

摘要： The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a differential electromagnetic radiation (either different intensity, different frequency or no radiation), and wherein the arrangement of said portions of the surface defines a spatially distributed code for identifying the particle. The invention also provides method of manufacturing a particle having an identifying code comprising providing a particle with a functionalized surface which comprises functional binding moieties and selectively removing a plurality of the functional binding moieties from the surface to create a pattern of functionalized and differentially-functionalized zones on the surface. Various liquid-based assay methods employing the particle of the invention and a kit comprising the particle of the invention are also disclosed.

摘要翻译： 本发明提供一种包括表面的颗粒，其中表面的一部分能够发射电磁辐射，并且表面的另一部分能够发射差分电磁辐射（不同强度，不同频率或不辐射），并且其中 表面的所述部分的布置限定了用于识别颗粒的空间分布的代码。 本发明还提供了制造具有识别代码的颗粒的方法，该方法包括向颗粒提供包含功能性结合部分的官能化表面，并从表面选择性地除去多个功能结合部分以产生官能化和差异功能化区域的图案 在表面上。 还公开了使用本发明颗粒的各种液体测定方法和包含本发明颗粒的试剂盒。

公开(公告)号：US20100167941A1

公开(公告)日：2010-07-01

申请号：US12462921

申请日：2009-08-11

申请人： Nigel G. Skinner ,  Paul Fenton ,  George A. Adaniya

发明人： Nigel G. Skinner ,  Paul Fenton ,  George A. Adaniya

IPC分类号： C40B30/02 ,  C40B60/12 ,  C40B50/14 ,  C40B40/06 ,  C40B30/04

CPC分类号： G01N33/54346 ,  C12Q1/6827 ,  C12Q1/6874 ,  G01N33/54373 ,  Y10T428/2982 ,  Y10T436/13 ,  C12Q2565/501 ,  C12Q2563/185 ,  C12Q2563/149

摘要： The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a differential electromagnetic radiation (either different intensity, different frequency or no radiation), and wherein the arrangement of said portions of the surface defines a spatially distributed code for identifying the particle. The invention also provides method of manufacturing a particle having an identifying code comprising providing a particle with a functionalized surface which comprises functional binding moieties and selectively removing a plurality of the functional binding moieties from the surface to create a pattern of functionalized and differentially-functionalized zones on the surface. Various liquid-based assay methods employing the particle of the invention and a kit comprising the particle of the invention are also disclosed.

摘要翻译： 本发明提供一种包括表面的颗粒，其中表面的一部分能够发射电磁辐射，并且表面的另一部分能够发射差分电磁辐射（不同强度，不同频率或不辐射），并且其中 表面的所述部分的布置限定了用于识别颗粒的空间分布的代码。 本发明还提供了制造具有识别代码的颗粒的方法，该方法包括向颗粒提供包含功能性结合部分的官能化表面，并从表面选择性地除去多个功能结合部分以产生官能化和差异功能化区域的图案 在表面上。 还公开了使用本发明颗粒的各种液体测定方法和包含本发明颗粒的试剂盒。