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1.发明授权Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer 失效基质金属蛋白酶1型（TIMP-1）的组织抑制剂作为癌症标志物，并且具有癌症病史的患者中残留病或复发性疾病的最小残留标志物公开(公告)号：US07374886B2
公开(公告)日：2008-05-20
申请号：US10117030
申请日：2002-04-08
IPC分类号： G01N33/53
CPC分类号： G01N33/57484 , G01N33/57415 , G01N33/57419 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent cancer after being treated for the primary cancer by determining a parameter representing the post-operative TIMP-1 concentration in body fluid samples from the individual. In addition, the invention describes the additive effect of combined post-operative measurements of plasma TIMP-1 and serum CEA.
摘要翻译： 本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否患有癌症的方法。 本发明还描述了一种用于通过确定表示来自个体的体液样品中的手术后TIMP-1浓度的参数来确定个体是否患有原发性癌症治疗后的最小残留疾病或复发性癌症的方法。 此外，本发明描述了血浆TIMP-1和血清CEA组合术后测量的叠加效应。
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2.发明申请TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER 审中-公开基质金属蛋白酶1（TIMP-1）作为癌症标记物的组织抑制剂公开(公告)号：US20110060529A1
公开(公告)日：2011-03-10
申请号：US12871735
申请日：2010-08-30
申请人： Mads Holten-Andersen , Ross W. Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
发明人： Mads Holten-Andersen , Ross W. Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
摘要翻译： 本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否可能患有癌症的方法。
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公开(公告)号：US06224865B1
公开(公告)日：2001-05-01
申请号：US08583129
申请日：1996-05-15
申请人： Nils Brünner , John Rømer , Vincent Ellis , Charles Pyke , Jan Grøndahl-Hansen , Helle Pedersen , Heine Høi Hansen , Keld Danø
发明人： Nils Brünner , John Rømer , Vincent Ellis , Charles Pyke , Jan Grøndahl-Hansen , Helle Pedersen , Heine Høi Hansen , Keld Danø
IPC分类号： A61K39395
CPC分类号： G01N33/573 , A61K38/49 , A61K38/57 , A61K48/00 , C07K16/38 , G01N33/574 , G01N2333/47 , G01N2333/4704 , G01N2333/81
摘要： The present invention relates to methods for inhibiting malignant tumour growth, invasion and/or metastasis in a patient, the method comprising suppressing the inhibitory activity of an inhibitor of a protease or of a non-proteolytic matrix-degrading enzyme (IPNME) in malignant tumour tissue or potential malignant tumour tissue. The suppression may be brought about by administering compounds interacting with the IPNME, but also administration of compounds interacting with transcription of genes encoding the IPNME is a possibility. The invention also relates to methods of selecting and identifying compounds in the therapeutical methods, as well of the use of such compounds in the treatment of malignancies.
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4.发明授权Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker 失效基质金属蛋白酶1型（TIMP-1）的组织抑制剂作为癌症标志物公开(公告)号：US07807379B2
公开(公告)日：2010-10-05
申请号：US11449869
申请日：2006-06-09
申请人： Mads Holten-Andersen , Ross Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
发明人： Mads Holten-Andersen , Ross Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
IPC分类号： G01N33/53
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
摘要翻译： 本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否可能患有癌症的方法。
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5.发明申请TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER AND POSTOPERATIVE MARKER FOR MINIMAL RESIDUAL DISEASE OR RECURRENT DISEASE IN PATIENTS WITH A PRIOR HISTORY OF CANCER 审中-公开作为癌症标志物的基质金属蛋白酶1（TIMP-1）的组织抑制剂和用于癌症以前的病史的患者的最小残留疾病或复发性疾病的手术标记公开(公告)号：US20110294148A1
公开(公告)日：2011-12-01
申请号：US13198519
申请日：2011-08-04
IPC分类号： G01N33/566 , G01N27/447 , G06F19/00 , G01N33/559
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent cancer after being treated for the primary cancer by determining a parameter representing the post-operative TIMP-1 concentration in body fluid samples from the individual. In addition, the invention describes the additive effect of combined post-operative measurements of plasma TIMP-1 and serum CEA.
摘要翻译： 本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否患有癌症的方法。 本发明还描述了一种用于通过确定表示来自个体的体液样品中的手术后TIMP-1浓度的参数来确定个体在治疗原发性癌症后是否患有最小残留疾病或复发性癌症的方法。 此外，本发明描述了血浆TIMP-1和血清CEA组合术后测量的叠加效应。
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6.发明授权Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker 失效基质金属蛋白酶1型（TIMP-1）的组织抑制剂作为癌症标志物公开(公告)号：US07108983B1
公开(公告)日：2006-09-19
申请号：US09546573
申请日：2000-04-10
申请人： Mads N. Holten-Andersen , Ross W. Stephens , Hans Jorgen Nielsen , Ib Jarle Christensen , Nils Brünner
发明人： Mads N. Holten-Andersen , Ross W. Stephens , Hans Jorgen Nielsen , Ib Jarle Christensen , Nils Brünner
IPC分类号： G01N33/53
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
摘要翻译： 本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否可能患有癌症的方法。
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