公开(公告)号：US06224865B1

公开(公告)日：2001-05-01

申请号：US08583129

申请日：1996-05-15

申请人： Nils Brünner ,  John Rømer ,  Vincent Ellis ,  Charles Pyke ,  Jan Grøndahl-Hansen ,  Helle Pedersen ,  Heine Høi Hansen ,  Keld Danø

发明人： Nils Brünner ,  John Rømer ,  Vincent Ellis ,  Charles Pyke ,  Jan Grøndahl-Hansen ,  Helle Pedersen ,  Heine Høi Hansen ,  Keld Danø

IPC分类号： A61K39395

CPC分类号： G01N33/573 ,  A61K38/49 ,  A61K38/57 ,  A61K48/00 ,  C07K16/38 ,  G01N33/574 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/81

摘要： The present invention relates to methods for inhibiting malignant tumour growth, invasion and/or metastasis in a patient, the method comprising suppressing the inhibitory activity of an inhibitor of a protease or of a non-proteolytic matrix-degrading enzyme (IPNME) in malignant tumour tissue or potential malignant tumour tissue. The suppression may be brought about by administering compounds interacting with the IPNME, but also administration of compounds interacting with transcription of genes encoding the IPNME is a possibility. The invention also relates to methods of selecting and identifying compounds in the therapeutical methods, as well of the use of such compounds in the treatment of malignancies.

公开(公告)号：US06248712B1

公开(公告)日：2001-06-19

申请号：US08442108

申请日：1995-05-16

申请人： Keld Danø ,  Francesco Blasi ,  Ann Louring Roldan ,  Maria Vittoria Cubellis ,  Maria Teresa Masucci ,  Ettore Appella ,  W.D. Schleuning ,  Niels Behrendt ,  Ebbe Rønne ,  Peter Kristensen ,  Jari Pöllänen ,  Eeva-Marjatta Salonen ,  Ross W. Stephens ,  Hannele Tapiovaara ,  Antti Vaheri ,  Lisbeth Birk Møller ,  Vincent Ellis ,  Leif Røge Lund ,  Michael Ploug ,  Charles Pyke ,  Lászl{acute over (o )} Patthy

发明人： Keld Danø ,  Francesco Blasi ,  Ann Louring Roldan ,  Maria Vittoria Cubellis ,  Maria Teresa Masucci ,  Ettore Appella ,  W.D. Schleuning ,  Niels Behrendt ,  Ebbe Rønne ,  Peter Kristensen ,  Jari Pöllänen ,  Eeva-Marjatta Salonen ,  Ross W. Stephens ,  Hannele Tapiovaara ,  Antti Vaheri ,  Lisbeth Birk Møller ,  Vincent Ellis ,  Leif Røge Lund ,  Michael Ploug ,  Charles Pyke ,  Lászl{acute over (o )} Patthy

IPC分类号： C07K1400

CPC分类号： C12N9/6462 ,  A61K38/00 ,  A61K38/1808 ,  A61K38/49 ,  A61K39/3955 ,  C07K14/705 ,  C07K16/28 ,  C07K16/2896 ,  C07K2317/76 ,  C07K2317/77 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y304/21073 ,  G01N33/57446 ,  G01N33/86 ,  G01N2333/9723 ,  A61K2300/00

摘要： Activation of plasminogen to plasmin is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator receptor are provided.

摘要翻译： 通过阻止哺乳动物中尿激酶型纤溶酶原激活剂受体结合形式与尿激酶型纤溶酶原激活物受体的结合，从而阻止尿激酶型纤溶酶原激活剂将纤溶酶原转化成纤溶酶，来抑制纤溶酶原对纤溶酶的激活。 提供了编码尿激酶型纤溶酶原激活物受体的可溶性活性片段的DNA片段。

公开(公告)号：US07026282B1

公开(公告)日：2006-04-11

申请号：US09743329

申请日：1999-07-01

申请人： Michael Ploug ,  Søren Østergaard ,  Claus Holst-Hansen ,  Ross Stephens ,  Keld Danø ,  Arne Holm

发明人： Michael Ploug ,  Søren Østergaard ,  Claus Holst-Hansen ,  Ross Stephens ,  Keld Danø ,  Arne Holm

IPC分类号： C07K7/00 ,  C07K7/06

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/6462 ,  C12Y304/21073 ,  G01N33/5011 ,  G01N33/68 ,  G01N2500/00

摘要： A novel set of inhibitors of the binding interaction between human urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR) has been developed. The inhibitors comprise of peptide fragments, monomeric or in multiple copies attached to a common scaffold, in which the amino acid sequence may include uncommon substituted amino acids to partially comprise of peptoid sequences. The present invention also relates to the use of such peptides in therapy, in particular for the treatment of cancer, having developed a modified non-human mammalian receptor to which the novel inhibitors are antagonistic.

摘要翻译： 已经开发了一组新的人类尿激酶纤溶酶原激活物（uPA）与其细胞表面受体（uPAR）之间的结合相互作用的抑制剂。 所述抑制剂包含连接于常见支架的单体或多拷贝的肽片段，其中氨基酸序列可以包括不常见的取代的氨基酸部分包含拟肽序列。 本发明还涉及这种肽在治疗中的用途，特别是用于治疗癌症，已开发了新的抑制剂对其拮抗的修饰的非人哺乳动物受体。