公开(公告)号：US20060134158A1

公开(公告)日：2006-06-22

申请号：US10519541

申请日：2003-06-26

申请人： Tokifumi Majima ,  Norimasa Iwasaki ,  Tadanao Funakoshi ,  Akio Minami ,  Shin-ichiro Nishimura ,  Seiichi Tokura ,  Kazuo Harada ,  Sachiko Nonaka ,  Nobuhiki Maekawa

发明人： Tokifumi Majima ,  Norimasa Iwasaki ,  Tadanao Funakoshi ,  Akio Minami ,  Shin-ichiro Nishimura ,  Seiichi Tokura ,  Kazuo Harada ,  Sachiko Nonaka ,  Nobuhiki Maekawa

IPC分类号： C12N5/08 ,  B32B27/04 ,  A61F13/00

CPC分类号： A61L27/3817 ,  A61K35/12 ,  A61L27/20 ,  A61L27/3804 ,  A61L27/3843 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/58 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/72 ,  C12N2533/74 ,  D01F8/16 ,  Y10T442/2566 ,  C08L5/08

摘要： It is intended to provide a three-dimensional scaffolds appropriate for culturing animal cells such as chondrocytes and fibroblasts. These three-dimensional scaffolds which comprise a chitosan/acidic biopolymers hybrid fibers composed of chitosan or its salts in the inside of the fiber and complexes of chitosan with biodegradable acidic biopolymers coating the fiber surface, are made of fibers capable of retaining their shapes after allowing to stand Dulbecco's modified Eagle's medium (DMEM) containing 10% of FBS (fetal bovine serum) at room temperature for 2 weeks.

摘要翻译： 旨在提供适合于培养动物细胞如软骨细胞和成纤维细胞的三维支架。 这些三维支架由纤维内部由壳聚糖或其盐形成的壳聚糖/酸性生物聚合物混合纤维和壳聚糖与可生物降解的酸性生物聚合物复合物包覆纤维表面组成，由能够在允许后保留其形状的纤维制成 在室温下放置含有10％FBS（胎牛血清）的Dulbecco改良的Eagle培养基（DMEM）2周。