公开(公告)号：US20070196906A1

公开(公告)日：2007-08-23

申请号：US10594731

申请日：2005-03-28

申请人： Kazuya Matsumoto ,  Yasushi Kazuno ,  Norikazu Higashimura ,  Toshihisa Ohshima ,  Haruhiko Sakuraba

发明人： Kazuya Matsumoto ,  Yasushi Kazuno ,  Norikazu Higashimura ,  Toshihisa Ohshima ,  Haruhiko Sakuraba

IPC分类号： C12P7/24

CPC分类号： C12P7/24 ,  C12P17/06

摘要： An industrial process for producing hydroxyaldehydes efficiently, by solving the problems of conventional DERA, such as low stability against aldehydes, low catalytic activity for aldol condensation, and the difficulty of controlling the number of acetaldehyde molecules to be condensed, is provided. According to the process, aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with acetaldehyde is conducted by using D-2-deoxyribose-5-phosphate aldolase which is highly stable against aldehydes and has high catalytic activity for aldol condensation, whereby a hydroxyaldehyde compound having the number of carbon atoms increased by two or four can be produced.

摘要翻译： 提供了通过解决常规DERA的问题，例如对醛的低稳定性，醛醇缩合的低催化活性和难以控制缩合的乙醛分子的数量来有效生产羟醛的工业方法。 根据该方法，取代或未取代的具有2-6个碳原子的脂族醛化合物与乙醛的醛醇缩合通过使用对醛高度稳定的D-2-脱氧核糖-5-磷酸醛缩酶进行，并且对于醛醇具有高催化活性 缩合，由此可以制备碳原子数增加2或4的羟基醛化合物。

公开(公告)号：US06333035B1

公开(公告)日：2001-12-25

申请号：US09308332

申请日：1999-05-19

申请人： Kazuo Sugamura ,  Kazuko Murata ,  Norikazu Higashimura

发明人： Kazuo Sugamura ,  Kazuko Murata ,  Norikazu Higashimura

IPC分类号： A61K39395

CPC分类号： C07K16/2875 ,  A61K2039/505

摘要： The present invention relates to a pharmaceutical composition for the therapeutic treatment of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, sarcoidosis, autoimmune uveitis, and inflammatory bowel disease, or graft-versus-host disease. The pharmaceutical composition contains, as the effective ingredient, a gp34 binding-inhibitory substance.

摘要翻译： 本发明涉及用于治疗性治疗包括类风湿性关节炎，多发性硬化，结节病，自身免疫性葡萄膜炎和炎症性肠病或移植物抗宿主病的自身免疫性疾病的药物组合物。 药物组合物含有作为有效成分的gp34结合抑制物质。

公开(公告)号：US07402710B2

公开(公告)日：2008-07-22

申请号：US10594731

申请日：2005-03-28

申请人： Kazuya Matsumoto ,  Yasushi Kazuno ,  Norikazu Higashimura ,  Toshihisa Ohshima ,  Haruhiko Sakuraba

发明人： Kazuya Matsumoto ,  Yasushi Kazuno ,  Norikazu Higashimura ,  Toshihisa Ohshima ,  Haruhiko Sakuraba

IPC分类号： C07C45/72

CPC分类号： C12P7/24 ,  C12P17/06

摘要： An industrial process for producing hydroxyaldehydes efficiently, by solving the problems of conventional DERA, such as low stability against aldehydes, low catalytic activity for aldol condensation, and the difficulty of controlling the number of acetaldehyde molecules to be condensed, is provided.According to the process, aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with acetaldehyde is conducted by using D-2-deoxyribose-5-phosphate aldolase which is highly stable against aldehydes and has high catalytic activity for aldol condensation, whereby a hydroxyaldehyde compound having the number of carbon atoms increased by two or four can be produced.

摘要翻译： 提供了通过解决常规DERA的问题，例如对醛的低稳定性，醛醇缩合的低催化活性和难以控制缩合的乙醛分子的数量来有效生产羟醛的工业方法。 根据该方法，取代或未取代的具有2-6个碳原子的脂族醛化合物与乙醛的醛醇缩合通过使用对醛高度稳定的D-2-脱氧核糖-5-磷酸醛缩酶进行，并且对于醛醇具有高催化活性 缩合，由此可以制备碳原子数增加2或4的羟基醛化合物。