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公开(公告)号：US08483468B2
公开(公告)日：2013-07-09
申请号：US13270420
申请日：2011-10-11
申请人： Noriyuki Shuke
发明人： Noriyuki Shuke
CPC分类号： A61B5/02755 , A61B5/02007 , A61B6/037 , A61B6/501 , A61B6/504 , A61B2576/026 , G21H5/02
摘要： [Object] To provide a method for accurately determining cerebral blood flows both in rest state and under medication with less invasive operations.[Solution] Cerebral blood flow is determined based on a formula represented by the following formulas (1) or (2) for a time under medication that continuously follows a resting time. B ( t ) = k 1 ⅇ - k 2 t 3 mC f ∫ 0 t 3 S ( τ ) ⅇ k 2 τ ⅆ τ ( ⅇ - k 2 d ( t - t 3 ) ) + k 1 d mC f ∫ t 3 t ( S ( τ ) + S ( τ - t 3 ) ) · ⅇ - k 2 d · ( t - τ ) ⅆ τ ( t ≥ t 3 ) ( 1 ) ∫ t 5 t 6 B ( t ) ⅆ t = k 1 k 2 d ⅇ - k 2 t 3 mC f ∫ 0 t 3 S ( τ ) ⅇ k 2 τ ⅆ τ · ( ⅇ - k 2 d ( t 5 - t 3 ) - ⅇ - k 2 d ( t 6 - t 3 ) ) + ∫ t 5 t 6 k 1 d mC f ∫ t 3 t ( S ( τ ) + S ( τ - t 3 ) ) · ⅇ - k 2 d · ( t - τ ) ⅆ τ ⅆ t ( t ≥ t 3 ) ( 2 ) (B(t): the radiation count at the time of t, t3: the time when a radioisotope medicine is administered, t5: the time when acquisition of the imaging data started for the state under medication, t6: the time when acquisition of the imaging data finished for the state under medication, mCf: a scaling factor, k1: cerebral blood flow rest state, k2: the blood-outflow-rate-constant of brain tissues rest state, k1d: a cerebral blood flow under medication, and k2d: the blood-outflow-rate-constant of brain tissues under medication).
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2.发明申请CEREBRAL BLOOD FLOW QUANTIFICATION DEVICE, CEREBRAL BLOOD FLOW QUANTIFICATION METHOD AND PROGRAM 审中-公开谷胱甘肽流量定量装置，脑血流量定量方法与程序公开(公告)号：US20110002521A1
公开(公告)日：2011-01-06
申请号：US12867303
申请日：2009-01-15
IPC分类号： G06T7/00
CPC分类号： A61B5/02755 , A61B6/037 , A61B6/507 , G06T7/0012 , G06T2207/10104 , G06T2207/10108 , G06T2207/30016
摘要： A cerebral blood flow rate quantification device includes: a nuclear medicine image acquisition unit for acquiring a nuclear medicine image of the head of a subject administered with a radiopharmaceutical; a count calculation unit for calculating the number of counts obtained from a unit region; a cerebral blood flow rate calculation unit for calculating the value of a cerebral blood flow rate that makes the value of a function, which expresses the concentration of the radiopharmaceutical in brain tissue; and a cerebral blood flow map generation unit for generating a map showing cerebral blood flow based on the cerebral blood flow rate in each unit region. Consequently, the cerebral blood flow rate can be accurately quantified even at a relatively early stage after administration of a radiopharmaceutical.
摘要翻译： 脑血流量定量装置包括：核医学图像获取单元，其获取施用放射性药剂的患者的头部的核医学图像; 计数计算单元，用于计算从单位区域获得的计数数; 脑血流量计算单元，计算使脑组织中放射性药剂浓度为函数的函数值的脑血流量的值; 以及脑血流图生成部，其基于各单位区域的脑血流量生成表示脑血流量的图。 因此，即使在给药放射性药物后的较早阶段也可以准确地定量脑血流量。
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公开(公告)号：US08437523B2
公开(公告)日：2013-05-07
申请号：US13119914
申请日：2009-09-17
申请人： Noriyuki Shuke
发明人： Noriyuki Shuke
CPC分类号： A61B6/501 , A61B6/037 , A61B6/507 , G06F19/00 , G06F19/321 , G06K9/6255 , G06T7/0012 , G06T2207/10104 , G06T2207/10108 , G06T2207/30016
摘要： CPU 12 reads out the bloodstream associated values of target voxel of subject's standardized brain bloodstream images (step S34). CPU 12 sorts the bloodstream associated values in descending order (step S35). CPU 12 rejects bloodstream associated values that are ranked top 10% and bottom 40% (step S36). When the subjects are 20 for example, bloodstream associated values of highest 2 subjects and of lowest 8 subjects are rejected. CPU 12 calculates and stores mean value and standard deviation of remaining bloodstream associated values after the rejection (step S37). CPU 12 calculates mean value and standard deviation of bloodstream associated values for each voxel as target voxel (steps S31, S32, S33 and S38). Then, the alternative normal brain database of brain bloodstream image is obtained.
摘要翻译： CPU12读出对象标准化脑血流图像的目标体素的血流相关值（步骤S34）。 CPU12以降序对血流关联值进行排序（步骤S35）。 CPU 12拒绝排名前10％和最低40％的血流相关值（步骤S36）。 当对象为20例时，最高2名受试者和最低8名受试者的血流相关值被拒绝。 CPU12计算并存储在排斥之后剩余血流相关值的平均值和标准偏差（步骤S37）。 CPU 12计算每个体素作为目标体素的血流相关值的平均值和标准偏差（步骤S31，S32，S33和S38）。 然后，获得脑血流图像的替代正常脑数据库。
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公开(公告)号：US20120183192A1
公开(公告)日：2012-07-19
申请号：US13270420
申请日：2011-10-11
申请人： Noriyuki Shuke
发明人： Noriyuki Shuke
IPC分类号： G06K9/00
CPC分类号： A61B5/02755 , A61B5/02007 , A61B6/037 , A61B6/501 , A61B6/504 , A61B2576/026 , G21H5/02
摘要： [Object] To provide a method for accurately determining cerebral blood flows both in rest state and under medication with less invasive operations.[Solution] Cerebral blood flow is determined based on a formula represented by the following formulas (1) or (2) for a time under medication that continuously follows a resting time. B ( t ) = k 1 - k 2 t 3 mC f ∫ 0 t 3 S ( τ ) k 2 τ τ ( - k 2 d ( t - t 3 ) ) + k 1 d mC f ∫ t 3 t ( S ( τ ) + S ( τ - t 3 ) ) · - k 2 d · ( t - τ ) τ ( t ≥ t 3 ) ( 1 ) ∫ t 5 t 6 B ( t ) t = k 1 k 2 d - k 2 t 3 mC f ∫ 0 t 3 S ( τ ) k 2 τ τ · ( - k 2 d ( t 5 - t 3 ) - - k 2 d ( t 6 - t 3 ) ) + ∫ t 5 t 6 k 1 d mC f ∫ t 3 t ( S ( τ ) + S ( τ - t 3 ) ) · - k 2 d · ( t - τ ) τ t ( t ≥ t 3 ) ( 2 ) (B(t): the radiation count at the time of t, t3: the time when a radioisotope medicine is administered, t5: the time when acquisition of the imaging data started for the state under medication, t6: the time when acquisition of the imaging data finished for the state under medication, mCf: a scaling factor, k1: cerebral blood flow rest state, k2: the blood-outflow-rate-constant of brain tissues rest state, k1d: a cerebral blood flow under medication, and k2d: the blood-outflow-rate-constant of brain tissues under medication)
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