公开(公告)号：US09789130B2

公开(公告)日：2017-10-17

申请号：US14366839

申请日：2012-12-17

申请人： Nuria Izquierdo Useros ,  Hans-Georg Krauesslich ,  Maier Lorizate ,  Javier Martinez Picado

发明人： Nuria Izquierdo Useros ,  Hans-Georg Krauesslich ,  Maier Lorizate ,  Javier Martinez Picado

IPC分类号： A61K31/702 ,  A61K31/7028 ,  A61K31/7016 ,  G01N33/569 ,  A61K39/21 ,  A61K8/14 ,  C07K16/28 ,  A61K8/60 ,  A61K8/68 ,  A61K39/00

CPC分类号： A61K31/7028 ,  A61K8/14 ,  A61K8/602 ,  A61K8/68 ,  A61K31/7016 ,  A61K39/21 ,  A61K2039/5154 ,  C07K16/2803 ,  C12N2740/16034 ,  C12N2740/16061 ,  G01N33/56988 ,  G01N2333/16 ,  Y02A50/386 ,  Y02A50/388

摘要： The present invention refers to methods and compositions to prevent viral entry into cells expressing the CD169/sialoadhesin surface receptor by inhibiting the coupling of the sialyllactose molecule contained in the viral membrane gangliosides to the CD 169/sialoadhesin receptor. The invention also pertains to vaccine compositions based on dendritic cells loaded with an antigen of interest whereby the vaccine is provided together with a composition capable of preventing viral entry into cells expressing the CD169/sialoadhesin. Moreover, the invention relates to diagnostic and therapeutic compositions that can be specifically delivered to enveloped virions wherein the diagnostic/therapeutic agent is coupled to CD169/sialoadhesin.