公开(公告)号：US20220409726A1

公开(公告)日：2022-12-29

申请号：US17756253

申请日：2020-11-19

申请人： Nyctea Technologies AB

发明人： Gustav Ferrand-Drake del Castillo ,  Andreas Dahlin

IPC分类号： A61K41/00 ,  C08F292/00 ,  A61K47/64 ,  A61K47/60 ,  A61K47/69 ,  A61K47/58

摘要： An electrochemical catch-release system (1) for repeated use comprising pH-responsive polymers (2) covalently linked to a structure (3) via a monolayer (4) of eletrochemically insensitive aryl bonds, forming a polyelectrolyte arrangement (5), the polyelectrolyte arrangement (5) being arranged to, when the covalently bounded polymers (2) are in a neutral state, catch an entity (6) being a protein, a vesicle, or a compound modified with poly(ethylene glycol) by non-electrostatic interactions e.g. hydrogen bonds, and when the polymers (2) are in a charged state, release by electrostatic repulsion an entity (6) captured by the polyelectrolyte arrangement (5). The system also comprising a device (7) for applying an electrochemical potential to the polyelectrolyte arrangement (5) to induce a switch of the polyelectrolyte arrangement (5) from the neutral state to the charged state or the reverse in the presence of redox active species.