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公开(公告)号：US20230116627A1
公开(公告)日：2023-04-13
申请号：US17799440
申请日：2021-02-12
发明人： Renzhi HAN , Li XU , Yandi GAO
摘要： The present disclosure relates to nucleobase editors and methods of use thereof. Disclosed herein are fusion proteins, systems, and compositions for editing disease-associated mutations and methods of use thereof. In some aspects, disclosed herein is a fusion protein comprising a Cas9 nickase and a nucleotide deaminase, wherein the Cas9 nickase comprises a first amino acid substitution at a position selected from the group consisting of 262, 324, 409, 480, 543, 694, and 1219 when compared to SEQ ID NO: 11, and wherein the Cas9 nickase comprises a second amino acid substitution at a position selected from the group consisting of 1111, 1135, 1218, 1219, 1322, 1335, and 1337 when compared to SEQ ID NO: 11.
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公开(公告)号：US20230102038A1
公开(公告)日：2023-03-30
申请号：US17608441
申请日：2020-05-01
发明人： Rene Anand , Susan McKay
IPC分类号： C12N5/0793 , C12N5/079 , C12N5/071 , G01N33/68
摘要： Methods for using gene expression changes and mutations in neural organoids to identify neural networks that predict the onset of Alzheimer's disease and associated comorbidities are disclosed.
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公开(公告)号：US20230075548A1
公开(公告)日：2023-03-09
申请号：US17982732
申请日：2022-11-08
发明人： John F. Locke , Chi-Chih Chen , Jiukun Che
摘要： A multiband antenna comprises a dielectric substrate with a first surface defining an annular ledge and a central recess with a plurality of pockets. A MIMO radiator body is disposed in the central recess having a first surface defining a plurality of lobes which are disposed in respective ones of the plurality of pockets and having a second surface defining an outer rim and a central shelf A radiator ring is disposed at the annular ledge so that the radiator ring and the outer rim converge along an annular gap therebetween. A plurality of MIMO feed lines provide external connection to respective lobes. The MIMO radiator body and the radiator ring provide a substantially horizontally-directed radiation pattern (e.g., for terrestrial signals). At least one low-profile radiator on the central shelf provides a substantially circularly polarized or vertically-directed radiation pattern for receiving signals radiated from a satellite.
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4.发明申请公开(公告)号：US20230068000A1
公开(公告)日：2023-03-02
申请号：US17792602
申请日：2021-01-13
摘要： Colorimetric sensors for the detection of contaminants are described herein. In some implementations, the contaminant is formaldehyde. In other implementations, the contaminant is an allergen. Systems and methods for measuring contaminant concentration are also described herein. The colorimetric sensors described herein can be included in or used by disclosed systems and methods. Additionally, the systems and methods described herein can measure the concentration of the contaminant in an indoor environment using the colorimetric sensors.
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公开(公告)号：US20230060093A1
公开(公告)日：2023-02-23
申请号：US17789438
申请日：2020-12-28
发明人： W.S. Winston HO
摘要： Water permeable membranes and methods of preparation are described. The water permeable membrane can comprise a porous support, and a polyamide layer comprising a crosslinked polyamide on a surface of the porous support, wherein the polyamide layer further comprises nanoparticles and a hydrophilic additive, and wherein the hydrophilic additive covalently bonds to the crosslinked polyamide. The crosslinked polyamide can be interfacially polymerized on the porous support. Methods for desalinating water, performing dialysis, or performing pervaporation using the water permeable membranes are disclosed.
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公开(公告)号：US11564598B2
公开(公告)日：2023-01-31
申请号：US16522594
申请日：2019-07-25
发明人： Asimina Kiourti , Vigyanshu Mishra
摘要： A system and method are provided for monitoring body kinematics. A wearable coil configuration of the system comprises at least first and second electrically-conductive coils adapted to be secured to a subject in a predetermined spatial relationship and orientation relative to one another. The first coil acts as a first transmitter and generates a first magnetic flux when a first electrical current is passed through it. The second coil acts as a receiver. The first magnetic flux induces a first electrical current or voltage in the second coil. A measurement instrument of the system is configured to measure the first electrical current or voltage and to output a first measurement signal. A processor, which may be part of, or external to, the system is configured to execute a motion monitoring algorithm that processes at least the measurement signal to determine at least a first motion made by the subject.
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公开(公告)号：US20230026978A1
公开(公告)日：2023-01-26
申请号：US17859071
申请日：2022-07-07
发明人： M. Monica Giusti , Yucheng Zhou
IPC分类号： C07H17/065 , C07B35/08 , A61K8/60 , A23L5/43
摘要： Disclosed herein are photoisomerized compositions comprising anthocyanins and methods of making an use thereof. For example, disclosed herein are methods of photoisomerizing a composition, the methods comprising: irradiating a composition comprising an anthocyanin dissolved in a solvent solution with UV light; wherein at least a portion of the anthocyanin is present as a trans isomer before the irradiation; wherein the solvent solution comprises ethanol and water in a ratio of ethanol to water (volume/volume) of 99:1 to 70:30; thereby converting at least a portion of trans isomer to a cis isomer via photoisomerization to produce a photoisomerized composition. In some examples, the photoisomerized composition has a more intense and stable blue color at pH 8 relative to the composition before irradiation.
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公开(公告)号：US20230003741A1
公开(公告)日：2023-01-05
申请号：US17780321
申请日：2020-11-24
发明人： Sakima SMITH , Craig MCELROY , Patrick DIB
摘要： Disclosed are compositions and methods for determining aberrant cardiac function or a predisposition to aberrant cardiac function, said method comprising detecting a fragment of βII spectrin associated with aberrant cardiac function or a predisposition to aberrant cardiac function in a sample derived from a subject, wherein the detection is indicative of aberrant cardiac function in the subject.
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公开(公告)号：US20220387317A1
公开(公告)日：2022-12-08
申请号：US17775236
申请日：2020-11-06
IPC分类号： A61K9/127 , A61K31/352 , A61K31/4709 , A61K31/7048
摘要： Disclosed are compositions engineered nanovesicles and compositions comprising CD38 inhibitors and methods of using said nanovesicles and compositions to treat an inflammatory liver disease as well as in inhibiting, reducing, or repairing tissue damage to a donor organ or tissue during a transplantation procedure. In one aspect, also disclosed are method of preparing a donor organ or tissue for transplant comprising contacting the organ or tissue with the engineered nanovesicle or compositions disclosed herein.
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10.发明授权公开(公告)号：US11518790B2
公开(公告)日：2022-12-06
申请号：US16471808
申请日：2017-12-20
发明人： Daniel Gallego-Perez , Ly James Lee , Durba Pal , Subhadip Ghatak , Chandan Sen
摘要： Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.
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