公开(公告)号：US11951229B2

公开(公告)日：2024-04-09

申请号：US17407982

申请日：2021-08-20

Applicant: AOBAKASEI KABUSHIKI KAISHA ,  OSAKA CITY UNIVERSITY IN UNIVERSITY PUBLIC CORPORATION OSAKA

Inventor： Hirotsugu Kido ,  Katsunori Chiba ,  Hironori Arima ,  Kenji Ohata

IPC: A61L26/00

CPC classification number: A61L26/0038 ,  A61L26/0004 ,  A61L26/0023 ,  A61L26/0047 ,  A61L2400/04

Abstract: To provide a liquid medical material maintaining a colloid in a more sol form than a solid at normal temperature, having a higher function as a wound dressing material and a hemostatic material than fibrin glue, and being able to be produced safely and inexpensively. A gelatin aqueous solution including calcium at a concentration of 0.2 M or more and 1.0 M or less, and having a concentration of 5% by weight or more and 40% by weight or less, an average molecular weight of 80,000 or more and 120,000 or less, and a molecular weight distribution of 20,000 or more and 300,000 or less, and transglutaminase inducing crosslinking of the gelatin, are included. It is preferable that the calcium has a concentration of 0.2 M or more and 0.7 M or less, the gelatin has a bloom of 160 or more and 250 or less, and the transglutaminase has activity per unit of 36 U/ml to 400 U/ml.

公开(公告)号：US20220054701A1

公开(公告)日：2022-02-24

申请号：US17407982

申请日：2021-08-20

Applicant: AOBAKASEI KABUSHIKI KAISHA ,  OSAKA CITY UNIVERSITY IN UNIVERSITY PUBLIC CORPORATION OSAKA

Inventor： Hirotsugu KIDO ,  Katsunori CHIBA ,  Hironori ARIMA ,  Kenji OHATA

IPC: A61L26/00

Abstract: To provide a liquid medical material maintaining a colloid in a more sol form than a solid at normal temperature, having a higher function as a wound dressing material and a hemostatic material than fibrin glue, and being able to be produced safely and inexpensively. A gelatin aqueous solution including calcium at a concentration of 0.2 M or more and 1.0 M or less, and having a concentration of 5% by weight or more and 40% by weight or less, an average molecular weight of 80,000 or more and 120,000 or less, and a molecular weight distribution of 20,000 or more and 300,000 or less, and transglutaminase inducing crosslinking of the gelatin, are included. It is preferable that the calcium has a concentration of 0.2 M or more and 0.7 M or less, the gelatin has a bloom of 160 or more and 250 or less, and the transglutaminase has activity per unit of 36 U/ml to 400 U/ml.