公开(公告)号：US20230413826A1

公开(公告)日：2023-12-28

申请号：US18212471

申请日：2023-06-21

申请人： Matoke Holdings Limited

发明人： Thomas Hall ,  Sophie Constance Cox ,  Liam Michael Grover ,  David Kershaw

IPC分类号： A01N59/00 ,  A61K9/06 ,  A61K38/36 ,  A61K38/44 ,  A61K38/48 ,  A61K47/26 ,  A61K47/32 ,  A61K47/40 ,  A61L26/00 ,  A01N63/50

CPC分类号： A01N59/00 ,  A61K9/06 ,  A61K38/363 ,  A61K38/443 ,  A61K38/4833 ,  A61K47/26 ,  A61K47/32 ,  A61K47/40 ,  A61L26/0014 ,  A61L26/0042 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/0095 ,  A01N63/50 ,  C12Y101/03004

摘要： A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.

公开(公告)号：US20230256136A1

公开(公告)日：2023-08-17

申请号：US18018275

申请日：2021-07-28

申请人： University of Georgia Research Foundation, Inc.

发明人： Hitesh HANDA ,  Sama GHALEI

IPC分类号： A61L26/00

CPC分类号： A61L26/0066 ,  A61L26/008 ,  A61L26/0085 ,  A61L26/0047 ,  A61L2300/114 ,  A61L2300/406 ,  A61L2300/624 ,  A61L2400/12 ,  B82Y5/00

摘要： Described herein are biocompatible materials that include a nitric oxide (NO) donor embedded in silk fibroin nanoparticles. In one aspect, the nitric oxide donor is present in the hydrophobic core of the silk fibroin nanoparticles such that the nitric oxide donor is encapsulated. The biocompatible materials described herein serve as a biocompatible and inexpensive nitric oxide delivery platform that provide sustained release of nitric oxide. The biocompatible materials are non-toxic and can be used in biomedical applications such as wound healing, where a combination of therapeutic and antibacterial properties of silk and nitric oxide are desired. Additionally, described herein are methods of making the biocompatible materials.

公开(公告)号：US20180207232A1

公开(公告)日：2018-07-26

申请号：US15746508

申请日：2016-07-21

申请人： Temple University-Of The Commonwealth System of Higher Education

发明人： Peter I. Lelkes ,  Yah-el H. Har-el ,  Cezary Marcinkiewicz ,  Philip Lazarovici ,  Sogol Moaiyed Baharlou ,  Jonathan A. Gerstenhaber

IPC分类号： A61K38/16 ,  A61L27/54 ,  A61L27/18 ,  A61L27/52 ,  A61L27/22 ,  A61P17/02

CPC分类号： A61K38/168 ,  A61L15/26 ,  A61L15/32 ,  A61L15/44 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/008 ,  A61L27/18 ,  A61L27/222 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/412 ,  A61P17/02 ,  C08L67/04

摘要： Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.

公开(公告)号：US09999703B2

公开(公告)日：2018-06-19

申请号：US14980254

申请日：2015-12-28

申请人： FERROSAN MEDICAL DEVICES A/S

发明人： Kristian Larsen

IPC分类号： A61K38/48 ,  A61K9/19 ,  A61K31/047 ,  A61L26/00 ,  A61K31/70 ,  A61K9/16 ,  A61K38/01 ,  A61L24/00 ,  A61L24/10 ,  A61L2/04 ,  A61L2/08 ,  A61L2/10 ,  A61L2/20 ,  B65B1/04 ,  B65D81/32 ,  A61L2/07

CPC分类号： A61L26/0047 ,  A61K9/1658 ,  A61K31/047 ,  A61K31/70 ,  A61K38/014 ,  A61L2/04 ,  A61L2/07 ,  A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  A61L2/10 ,  A61L2/202 ,  A61L2/204 ,  A61L2/206 ,  A61L2/208 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/104 ,  A61L26/00 ,  A61L26/0038 ,  A61L26/0066 ,  A61L2300/254 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  A61L2400/06 ,  B65B1/04 ,  B65D81/32

摘要： The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.

公开(公告)号：US09982035B2

公开(公告)日：2018-05-29

申请号：US15103420

申请日：2014-12-15

申请人： Cambridge Enterprise Limited

发明人： James Andrew Huntington ,  Stéphanie Polderdijk ,  Trevor Baglin

IPC分类号： A61K38/36 ,  A61P7/02 ,  C07K14/745 ,  C07K14/81 ,  A61L26/00 ,  A61K38/00

CPC分类号： C07K14/8121 ,  A61K38/00 ,  A61L26/0047 ,  A61L2300/418 ,  A61L2400/04 ,  C07K14/8125

摘要： This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1′ residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.

公开(公告)号：US09981059B2

公开(公告)日：2018-05-29

申请号：US14780417

申请日：2014-03-21

申请人： Glytech, Inc.

发明人： Hayato Saijo ,  Hirofumi Ochiai ,  Keisuke Tazuru ,  Taiji Shimoda

IPC分类号： A61K38/14 ,  C07K9/00 ,  A61L26/00 ,  A61K47/42 ,  A61L33/12 ,  A61L15/32 ,  A61K47/61

CPC分类号： A61L26/008 ,  A61K47/42 ,  A61K47/61 ,  A61L15/32 ,  A61L26/0028 ,  A61L26/0047 ,  A61L26/009 ,  A61L33/12 ,  A61L2300/418 ,  A61L2300/604 ,  A61L2400/04

摘要： The object of the present invention is to provide a sugar chain-polypeptide complex that may form a transparent and homogeneous hydrogel in a broad pH. The present invention provides a sugar chain-polypeptide complex, characterized in that said polypeptide is a polypeptide comprising an amino acid sequence consisting of 8-34 amino acid residues in which polar and nonpolar amino acid residues are alternately arranged, and one or more sugar chains are bound to said polypeptide.

公开(公告)号：US20180078671A1

公开(公告)日：2018-03-22

申请号：US15829440

申请日：2017-12-01

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Donald R. Griffin ,  Westbrook Weaver ,  Tatiana Segura ,  Dino Di Carlo ,  Philip Scumpia

IPC分类号： A61L26/00 ,  A61L27/54 ,  A61L27/22 ,  A61L27/56 ,  A61L27/52

CPC分类号： A61L26/008 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/0085 ,  A61L26/009 ,  A61L27/18 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/00 ,  A61L2430/34 ,  C08L71/02

摘要： A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

公开(公告)号：US20170112754A1

公开(公告)日：2017-04-27

申请号：US15315795

申请日：2015-06-04

申请人： ZIM BIOSCIENCES, INC.

发明人： Jane M. Meyer ,  Nikita Malavia ,  Stephen Alexander Charles

IPC分类号： A61K8/86 ,  A61Q19/00 ,  C08G65/333 ,  A61K38/17 ,  A61K9/00 ,  A61Q7/00 ,  A61K8/65 ,  A61K31/77

CPC分类号： A61K8/86 ,  A61K8/65 ,  A61K9/0014 ,  A61K9/08 ,  A61K31/77 ,  A61K38/1748 ,  A61K47/34 ,  A61L15/32 ,  A61L15/44 ,  A61L26/0047 ,  A61L26/0066 ,  A61L2300/252 ,  A61L2300/412 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/007 ,  C08G65/33396

摘要： Provided herein are methods for improving skin quality in a subject comprising administering to the skin a pharmaceutical composition comprising a polypeptide covalently bound to a hydrophilic polymer and/or a polysaccharide covalently bound to a hydrophilic polymer.

公开(公告)号：US09592280B2

公开(公告)日：2017-03-14

申请号：US14511912

申请日：2014-10-10

申请人： ROCHAL INDUSTRIES, LLP

发明人： Joseph Charles Salamone ,  Kelly Xiaoyu Chen Leung ,  Ann Beal Salamone ,  Katelyn Elizabeth Reilly

IPC分类号： A61K38/54 ,  A61K31/155 ,  A61K31/785 ,  A61K38/47 ,  A61K45/06 ,  A61L26/00 ,  A61L15/38 ,  A61L15/44

CPC分类号： A61K38/54 ,  A61K31/155 ,  A61K31/785 ,  A61K38/47 ,  A61K45/06 ,  A61L15/38 ,  A61L15/44 ,  A61L26/0047 ,  A61L26/0066 ,  A61L2300/206 ,  A61L2300/254 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/45 ,  C12Y302/01001 ,  C12Y302/01002 ,  C12Y302/01003 ,  C12Y304/22032 ,  C12Y304/24007 ,  A61K2300/00

摘要： A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that α-amylase is effective in the debridement of devitalized tissue.

摘要翻译： 描述了坏死组织的清创酶，其不依赖于蛋白水解酶活性，而是利用酶的淀粉酶家族。 注意到淀粉酶（α-，β-，γ-淀粉酶）用于多糖的α-糖苷键的切割，产生较低分子量的碳水化合物/糖片段。 现在已经发现α-淀粉酶在清除失活的组织中是有效的。

公开(公告)号：US20170043051A1

公开(公告)日：2017-02-16

申请号：US15180889

申请日：2016-06-13

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Erin Lavik

IPC分类号： A61L26/00 ,  C08G81/00

CPC分类号： A61L26/0066 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0076 ,  A61L2300/222 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2300/624 ,  A61L2400/04 ,  A61L2400/12 ,  C08G81/00 ,  C08G2650/02 ,  C08G2650/38 ,  C08L71/02

摘要： The invention provides for dry spray compositions comprising co-polymers comprising a core, water-soluble polymer and a peptide.

摘要翻译： 本发明提供了包含包含核心，水溶性聚合物和肽的共聚物的干燥喷雾组合物。