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公开(公告)号:US10034958B2
公开(公告)日:2018-07-31
申请号:US14899727
申请日:2014-06-19
发明人: Akhilesh K. Gaharwar , Reginald Keith Avery , Gareth H. McKinley , Alireza Khademhosseini , Bradley David Olsen
CPC分类号: A61L26/0038 , A61K9/0019 , A61K9/5115 , A61L15/32 , A61L26/0004 , A61L26/008 , A61L26/0095 , A61L2300/252 , A61L2300/418 , A61L2400/04 , A61L2400/06 , A61L2400/12
摘要: Provided herein are hemostatic compositions useful for treating wounds in a patient in need thereof. An exemplary hemostatic comprises gelatin or a derivative thereof and silicate nanoparticles. Methods of use, kits comprising the compositions, and a process of making the compositions are also provided.
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公开(公告)号:US20180093011A1
公开(公告)日:2018-04-05
申请号:US15725213
申请日:2017-10-04
CPC分类号: A61L26/0038 , A61K9/0014 , A61K31/14 , A61K31/20 , A61K38/39 , A61L15/32 , A61L15/44 , A61L26/0033 , A61L26/0042 , A61L2300/404 , D01D5/0015 , D01D5/003 , D01F1/103
摘要: Compositions for enhancing wound healing are disclosed herein. Also disclosed are methods of making the compositions and methods of using the compositions for the prevention of biofilm formation and for the inhibition of pathogen growth and proliferation.
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公开(公告)号:US09889086B2
公开(公告)日:2018-02-13
申请号:US15013657
申请日:2016-02-02
发明人: Liming Bian , Qian Feng , Kongchang Wei , Gang Li , Sien Lin
IPC分类号: A61K47/40 , A61K47/42 , A61K9/00 , A61L26/00 , A61L27/22 , A61L27/52 , C08F289/00 , A61L27/54 , A61K47/32
CPC分类号: A61K9/0019 , A61K47/32 , A61K47/40 , A61K47/42 , A61L26/0038 , A61L26/0066 , A61L26/008 , A61L27/222 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2400/06 , C08F289/00
摘要: The present invention provides a novel hydrogel, methods of its use, and methods for producing the hydrogel.
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公开(公告)号:US20170290789A1
公开(公告)日:2017-10-12
申请号:US15484386
申请日:2017-04-11
申请人: Frank DICOSMO
发明人: Frank DICOSMO
CPC分类号: A61K31/155 , A01N47/44 , A61K47/02 , A61K47/10 , A61K47/36 , A61K47/38 , A61K47/42 , A61L26/0038 , A61L26/0066 , A61L2300/206 , A61L2300/404 , A61L2300/412
摘要: An isotonic irrigation solution for wounds, surgical incisions and as a lavage, the irrigation solution comprising saline, antimicrobial, chelator, surfactant and collagenous biological enhancer.
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公开(公告)号:US09265858B2
公开(公告)日:2016-02-23
申请号:US14516728
申请日:2014-10-17
发明人: Kristian Larsen
IPC分类号: A61K38/48 , A61L24/10 , A61L24/00 , A61L2/04 , A61L2/08 , A61L2/10 , A61L2/20 , B65B1/04 , A61L2/07
CPC分类号: A61L26/0047 , A61K9/1658 , A61K31/047 , A61K31/70 , A61K38/014 , A61L2/04 , A61L2/07 , A61L2/081 , A61L2/082 , A61L2/087 , A61L2/10 , A61L2/202 , A61L2/204 , A61L2/206 , A61L2/208 , A61L24/0015 , A61L24/0036 , A61L24/104 , A61L26/00 , A61L26/0038 , A61L26/0066 , A61L2300/254 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B1/04 , B65D81/32
摘要: Disclosed is a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. Further disclosed are methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.
摘要翻译: 公开了一种干组合物,其在添加水性介质时形成适用于止血程序的基本均匀的糊剂。 糊剂在加入液体后自发形成,因此不需要机械混合来形成所述糊料。 进一步公开的是制备所述干组合物的方法,由所述干组合物制成的糊剂和所述糊剂用于医疗和外科用途的方法。
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公开(公告)号:US08940335B2
公开(公告)日:2015-01-27
申请号:US13150902
申请日:2011-06-01
申请人: Andreas Goessl
发明人: Andreas Goessl
CPC分类号: A61K9/146 , A61K9/1658 , A61L26/0038 , A61L2400/04
摘要: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a dry granular preparation of a biocompatible polymer suitable for use in hemostasis, b) coating the granules in said dry granular preparation with a preparation of a coagulation inducing agent, thereby obtaining coagulation inducing agent coated polymer granules, c) filling said coagulation inducing agent coated polymer granules into a final container, d) finishing the final container to a storable pharmaceutical device containing said coagulation inducing agent coated polymer granules as a dry and stable hemostatic composition.
摘要翻译: 描述了一种制备干燥和稳定的止血组合物的方法,所述方法包括a)提供适用于止血的生物相容性聚合物的干燥颗粒制剂,b)用所述干燥颗粒制剂中的颗粒剂涂敷凝血诱导制剂 从而获得凝固诱导剂包被的聚合物颗粒,c)将所述凝固诱导剂包被的聚合物颗粒填充到最终容器中,d)将最终容器整理到含有所述凝固诱导剂包被的聚合物颗粒作为干燥和稳定的可储存药物装置 止血成分。
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公开(公告)号:US08821918B2
公开(公告)日:2014-09-02
申请号:US13967472
申请日:2013-08-15
发明人: Richard J. Greff
IPC分类号: A61F13/00 , A61K9/70 , A61L15/16 , A61L15/00 , A61L26/00 , A61K47/10 , A61K47/20 , A61K47/32 , A61K47/34 , A61K47/26 , A61K38/00
CPC分类号: A61K47/34 , A61K38/00 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/32 , A61L26/0038 , A61L26/0085 , A61L26/009 , A61L2400/04
摘要: Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution.
摘要翻译: 公开了一种生物相容性,止血的交联明胶组合物,其包含生物相容性材料,其包含交联明胶和足够量的润湿剂,以允许在水溶液存在下均匀地润湿海绵。
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公开(公告)号:US20130156824A1
公开(公告)日:2013-06-20
申请号:US13768033
申请日:2013-02-15
申请人: ETHICON, INC.
发明人: Scott Alan Keplinger
IPC分类号: A61L26/00
CPC分类号: A61L26/0052 , A61F13/122 , A61L15/24 , A61L15/32 , A61L15/58 , A61L15/62 , A61L15/64 , A61L24/06 , A61L26/0014 , A61L26/0038 , A61L2430/36 , C08L29/04 , C08L35/04
摘要: The present invention provides a wound dressing comprising a tessellated water-soluble molding matrix comprised of a polymer selected from the group consisting of polyvinyl alcohol, gelatin, and mixtures thereof and a 1,1-disubstituted ethylene monomer. The present invention further provides methods of using the wound dressing and kits containing the wound dressing.
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公开(公告)号:US20120329132A1
公开(公告)日:2012-12-27
申请号:US13555656
申请日:2012-07-23
申请人: Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人: Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC分类号: C12N9/10
CPC分类号: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地,可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地,无毒材料包含转谷氨酰胺酶(TG),其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶,其可以例如任选地是微生物转谷氨酰胺酶(mTG)。
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公开(公告)号:US20120277719A1
公开(公告)日:2012-11-01
申请号:US13459066
申请日:2012-04-27
申请人: Anita Shukla , Paula T. Hammond
发明人: Anita Shukla , Paula T. Hammond
CPC分类号: A61L26/0066 , A61L26/0038 , A61L2300/406 , A61L2300/608 , A61L2400/04 , A61L2420/02 , A61L2420/08 , A61M25/0045
摘要: The present disclosure provides, am ng other things, a coated device comprising: a porous substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer adjacent to the first layer, wherein the first layer comprises a first polymeric material and at least first interacting moiety, wherein the second layer comprises a second polymeric material and at least second interacting moiety, and wherein the interacting moieties on adjacent layers interact with one another so that the adjacent layers are associated with each other into the film; and an agent for delivery associated with the coated device, such that decomposition of one or more layers of the film results in release of the agent.
摘要翻译: 本公开提供了其它方面的涂覆装置,包括:多孔基材; 所述膜包含至少部分所述基底,所述膜包括多层单元,所述多层单元包括与所述第一层相邻的第一层和第二层,其中所述第一层包含第一聚合材料和至少第一相互作用部分,其中所述第二层 包括第二聚合材料和至少第二相互作用部分,并且其中相邻层上的相互作用部分彼此相互作用,使得相邻层彼此相关联成膜; 以及与涂布装置相关的递送剂,使得一层或多层薄膜的分解导致试剂的释放。
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