公开(公告)号：US20100261705A1

公开(公告)日：2010-10-14

申请号：US12611921

申请日：2009-11-03

申请人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Ohta Kazuhide ,  Masaaki Takano ,  Takumi Sumida

发明人： Takeshi Kuroda ,  Takahito Yamauchi ,  Tomoichi Shinohara ,  Kunio Oshima ,  Chiharu Kitajima ,  Hitoshi Nagao ,  Tae Fukushima ,  Takahiro Tomoyasu ,  Hironobu Ishiyama ,  Ohta Kazuhide ,  Masaaki Takano ,  Takumi Sumida

IPC分类号： A61K31/4709 ,  C07D417/10 ,  C07D417/14 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/506 ,  A61K31/473 ,  A61K31/498 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P27/02 ,  A61P35/00 ,  A61P17/02

CPC分类号： C07D471/08 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

摘要翻译： 本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病 疾病，呼吸道疾病，眼睛疾病，癌症和伤口。