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1.发明授权Use for bis-heterocyclic compounds and pharmaceutical compositions containing same 失效用于双杂环化合物和含有它们的药物组合物
公开(公告)号：US5464835A
公开(公告)日：1995-11-07
申请号：US201309
申请日：1994-02-24
IPC分类号： C07D403/14 , A61K31/415 , A61K31/495 , A61K35/56 , A61P29/00
CPC分类号： A61K31/415 , A61K31/495
摘要： A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, hamacanthins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.
摘要翻译： 用于生物活性双杂环类，例如双吲哚生物碱化合物的类别，其已被命名为topentins，nortopentin，胡桃黄素或dragmacidins，含有它们的药物组合物，制备化合物的方法和使用 公开了化合物。 具体地说，该新颖的用途涉及双吲哚化合物及其类似物所表现的抗炎特性。
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公开(公告)号：US5618837A
公开(公告)日：1997-04-08
申请号：US483216
申请日：1995-06-07
IPC分类号： A61K31/075 , A61K31/122 , A61K31/19 , A61K31/365 , A61P9/00 , A61K31/335 , A61K31/12
CPC分类号： A61K31/19 , A61K31/365
摘要： Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an effective amount of Brefeldin A or a derivative of Brefeldin A. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The non-peptide PDGF antagonists Brefeldin A and its derivatives may optionally be administered coordinately with heparin, whereby the coordinately administered of non-peptide PDGF antagonist and heparin are combinatorially effective in inhibiting intimal hyperplasia.
摘要翻译： 公开了抑制哺乳动物（包括灵长类动物）脉管系统内膜增生的方法。 所述方法包括向哺乳动物施用有效量的布雷菲德菌素A或布雷菲德菌素A的衍生物。该方法可用于减少由于血管成形术，内膜切除术，血管移植术中的粥样斑块切除术或吻合口引起的血管损伤引起的内膜增生 。 非肽PDGF拮抗剂Brefeldin A及其衍生物可以任选地与肝素配位施用，由此协调施用非肽PDGF拮抗剂和肝素在抑制内膜增生中是组合有效的。
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公开(公告)号：US4801607A
公开(公告)日：1989-01-31
申请号：US30727
申请日：1987-03-25
申请人： Shigeo Komoto , Oliver J. McConnell , Sue S. Cross
发明人： Shigeo Komoto , Oliver J. McConnell , Sue S. Cross
CPC分类号： C07D307/77 , C07J73/003
摘要： This invention relates to antitumor and antiviral furanoditerpenoid compositions, a process of producing the compositions and a method for inhibiting tumors and viruses utilizing the compositions. More particularly, the new compositions are antitumor and antiviral furanoterpenoids which are derived from marine organisms, i.e., the marine sponge Spongia sp.
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公开(公告)号：US5478861A
公开(公告)日：1995-12-26
申请号：US198747
申请日：1994-02-18
IPC分类号： C07D407/06 , A61K31/35 , A61K31/365 , A61P35/00 , C07D309/10 , C07D309/30 , C07D493/16 , C07D493/18 , C12P17/18 , A61K31/335
CPC分类号： C07D309/30 , C07D309/10 , C12P17/181
摘要： A novel macrolide compound, lasonolide A, has been isolated from a marine sponge. This compound, derivatives of the compound, and compositions comprising the compound or its derivatives, are useful as antitumor agents and as biochemical tools.
摘要翻译： 已经从海绵中分离出一种新型的大环内酯类化合物，它们是耐季铵盐A。 该化合物，化合物的衍生物和包含该化合物或其衍生物的组合物可用作抗肿瘤剂和生化工具。
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公开(公告)号：US4895844A
公开(公告)日：1990-01-23
申请号：US313281
申请日：1989-02-23
申请人： Shigeo Komoto , Oliver J. McConnell
发明人： Shigeo Komoto , Oliver J. McConnell
IPC分类号： C07D403/14
CPC分类号： C07D403/14
摘要： This invention relates to novel compositions which are useful as antitumor compositions, a process of producing the compositions and a method for inhibiting tumors, utilizing the compositions. More particularly, the novel compositions are indole alkaloid compositions which are derived from marine sponges of the family Biemnidae.
摘要翻译： 本发明涉及可用作抗肿瘤组合物的新型组合物，制备组合物的方法和利用该组合物抑制肿瘤的方法。 更具体地，新组合物是衍生自Biemnidae家族的海绵的吲哚生物碱组合物。
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公开(公告)号：US5684036A
公开(公告)日：1997-11-04
申请号：US473846
申请日：1995-06-07
IPC分类号： C07D407/06 , A61K31/35 , A61K31/351 , A61K31/365 , A61P35/00 , C07D309/10 , C07D309/30 , C07D493/16 , C07D493/18 , C12P17/18 , A61K31/335
CPC分类号： C07D309/10 , C07D309/30 , C12P17/181
摘要： Novel macrolide compounds, including Lasonolide A and Lasonolide B, have been isolated from a marine sponge. These compounds, analogs, derivatives, or isomers of these compounds, and compositions comprising the compounds or its derivatives, are useful as antitumor agents and as biochemical tools.
摘要翻译： 已经从海绵中分离出了新型的大环内酯类化合物，包括耐力赛A和Lasonolide B。 这些化合物的这些化合物，类似物，衍生物或异构体以及包含化合物或其衍生物的组合物可用作抗肿瘤剂和生化工具。
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公开(公告)号：US5496950A
公开(公告)日：1996-03-05
申请号：US330651
申请日：1994-10-28
IPC分类号： C07D403/14 , A61K31/415 , A61K31/495 , A61K35/56 , A61P29/00 , C07D241/02 , C07D241/04 , C07D403/02
CPC分类号： A61K31/415 , A61K31/495
摘要： A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, hamacanthins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.
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8.发明授权
公开(公告)号：US5290777A
公开(公告)日：1994-03-01
申请号：US21929
申请日：1993-02-24
IPC分类号： C07D403/14 , A61K31/415 , A61K31/495 , A61K35/56 , A61P29/00 , A61K31/31
CPC分类号： A61K31/415 , A61K31/495
摘要： A novel use for the class of biologically active bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.
摘要翻译： 已经公开了一类已被命名为topentins，nortopentins或dragmacidins的生物活性双吲哚生物碱化合物的新用途，含有它们的药物组合物，制备化合物的方法和使用该化合物的方法。 具体地说，该新颖的用途涉及双吲哚化合物及其类似物所表现的抗炎特性。
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