公开(公告)号：US20100041032A1

公开(公告)日：2010-02-18

申请号：US12298875

申请日：2007-04-30

申请人： Olivia Orozco ,  Michele Sanicola-Nadel ,  Eugene Choi ,  John Carulli ,  Richard Tizard ,  Suzanne Szak ,  Chao Sun

发明人： Olivia Orozco ,  Michele Sanicola-Nadel ,  Eugene Choi ,  John Carulli ,  Richard Tizard ,  Suzanne Szak ,  Chao Sun

IPC分类号： C12Q1/68 ,  C12P21/08 ,  C07K16/00 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.

摘要翻译： 本发明至少部分地基于在细胞中表达假性TDGF3（Cripto-3）的发现，特别是TDGF3过表达与细胞的转化相关，例如TDGF3在癌症中过表达 来自肿瘤组织的细胞系和细胞。 因此，本发明提供用于检测样品中TDGF3多核苷酸或多肽的存在的组合物，试剂盒和方法。 本发明还提供用于评估细胞是否被转化以及评估患者是否是抗Cripto抗体治疗的合适候选者的组合物，试剂盒和方法。