公开(公告)号：US20060107094A1

公开(公告)日：2006-05-18

申请号：US10982348

申请日：2004-11-03

申请人： Thomas Anderson ,  John Carulli

发明人： Thomas Anderson ,  John Carulli

IPC分类号： G06F11/00

CPC分类号： G06F11/008 ,  G06F11/24

摘要： According to one embodiment of the invention, a method for estimating the failure rate of semiconductor devices includes obtaining accelerated stress duration data for a plurality of semiconductor devices, determining which of the semiconductor devices fail, classifying the defects for the failed semiconductor devices, determining a distribution model for the accelerated stress duration data, determining a set of parameters for the distribution model, determining a relative proportion of each defect classification to the total number of defect classifications, determining temperature and voltage acceleration factors for each defect classification, identifying actual operating conditions for the semiconductor devices, comparing the actual operating conditions for the semiconductor device with the distribution model, and determining a defect ratio for the semiconductor devices at the actual operating conditions for a predetermined time period based on the comparison.

摘要翻译： 根据本发明的一个实施例，一种用于估计半导体器件的故障率的方法包括：获得用于多个半导体器件的加速应力持续时间数据，确定半导体器件中的哪一个失效，分类故障半导体器件的缺陷，确定 加速应力持续时间数据的分布模型，确定分布模型的一组参数，确定每个缺陷分类与缺陷分类总数的相对比例，确定每个缺陷分类的温度和电压加速因子，识别实际操作条件 对于半导体器件，将半导体器件的实际工作条件与分布模型进行比较，并且基于该比较，在实际工作条件下确定预定时间段内的半导体器件的缺陷率。

公开(公告)号：US20060028229A1

公开(公告)日：2006-02-09

申请号：US10938488

申请日：2004-09-10

申请人： Suresh Subramaniam ,  Kenneth Butler ,  John Carulli ,  Richard Lawrence

发明人： Suresh Subramaniam ,  Kenneth Butler ,  John Carulli ,  Richard Lawrence

IPC分类号： G01R31/26

CPC分类号： G01R31/2894 ,  G01R31/287

摘要： A method for test data-driven detection of outlier semiconductor devices. Some illustrative embodiments may be a method used to test a semiconductor die comprising performing a burn-in test of a plurality of sample semiconductor dies to identify a failure of a defective semiconductor die, correlating variations in a parameter with the failure (the parameter comprising a characteristic associated with the plurality of sample semiconductor dies), defining a parameter constraint associated with the parameter, performing a production test of a production semiconductor die, and identifying the production semiconductor die as an outlier semiconductor die (the outlier semiconductor die passing the production test, but failing to conform to the parameter constraint).

公开(公告)号：US20100041032A1

公开(公告)日：2010-02-18

申请号：US12298875

申请日：2007-04-30

申请人： Olivia Orozco ,  Michele Sanicola-Nadel ,  Eugene Choi ,  John Carulli ,  Richard Tizard ,  Suzanne Szak ,  Chao Sun

发明人： Olivia Orozco ,  Michele Sanicola-Nadel ,  Eugene Choi ,  John Carulli ,  Richard Tizard ,  Suzanne Szak ,  Chao Sun

IPC分类号： C12Q1/68 ,  C12P21/08 ,  C07K16/00 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.

摘要翻译： 本发明至少部分地基于在细胞中表达假性TDGF3（Cripto-3）的发现，特别是TDGF3过表达与细胞的转化相关，例如TDGF3在癌症中过表达 来自肿瘤组织的细胞系和细胞。 因此，本发明提供用于检测样品中TDGF3多核苷酸或多肽的存在的组合物，试剂盒和方法。 本发明还提供用于评估细胞是否被转化以及评估患者是否是抗Cripto抗体治疗的合适候选者的组合物，试剂盒和方法。

公开(公告)号：US07968680B2

公开(公告)日：2011-06-28

申请号：US11943501

申请日：2007-11-20

申请人： Cynthia Green ,  Victor Kotelianski ,  Antonin De Fougerolles ,  John Carulli ,  Catherine Hession

发明人： Cynthia Green ,  Victor Kotelianski ,  Antonin De Fougerolles ,  John Carulli ,  Catherine Hession

IPC分类号： C07K14/705 ,  A61K38/17

CPC分类号： C07K14/70532 ,  A61K38/00 ,  Y10S435/81

摘要： The present invention provides novel isolated BLAA polynucleotides and the membrane-associated or secreted polypeptides encoded by the BLAA polynucleotides. Also provided are the antibodies that immunospecifically bind to a BLAA polypeptide or any derivative, variant, mutant or fragment of the BLAA polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BLAA polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

摘要翻译： 本发明提供新的分离的BLAA多核苷酸和由BLAA多核苷酸编码的膜相关或分泌的多肽。 还提供了免疫特异性结合BLAA多肽或BLAA多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明另外提供了其中BLAA多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其它用途的方法。

公开(公告)号：US20090047217A1

公开(公告)日：2009-02-19

申请号：US11943501

申请日：2007-11-20

申请人： Cynthia Green ,  Victor Kotelianski ,  Antonin de Fougerolles ,  John Carulli ,  Catherine Hession

发明人： Cynthia Green ,  Victor Kotelianski ,  Antonin de Fougerolles ,  John Carulli ,  Catherine Hession

IPC分类号： A61K49/00 ,  C07K14/00 ,  C07K16/18 ,  C12P21/00 ,  A61P37/04 ,  G01N33/566 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K14/70532 ,  A61K38/00 ,  Y10S435/81

摘要： The present invention provides novel isolated BLAA polynucleotides and the membrane-associated or secreted polypeptides encoded by the BLAA polynucleotides. Also provided are the antibodies that immunospecifically bind to a BLAA polypeptide or any derivative, variant, mutant or fragment of the BLAA polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the BLAA polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

摘要翻译： 本发明提供新的分离的BLAA多核苷酸和由BLAA多核苷酸编码的膜相关或分泌的多肽。 还提供了免疫特异性结合BLAA多肽或BLAA多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明另外提供了其中BLAA多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其它用途的方法。

公开(公告)号：US20050142617A1

公开(公告)日：2005-06-30

申请号：US10834377

申请日：2004-04-29

申请人： John Carulli ,  Randall Little ,  Robert Recker ,  Mark Johnson

发明人： John Carulli ,  Randall Little ,  Robert Recker ,  Mark Johnson

IPC分类号： G01N33/50 ,  A01K20060101 ,  A61K20060101 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P1/14 ,  A61P3/14 ,  A61P5/14 ,  A61P7/00 ,  A61P15/08 ,  A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P25/32 ,  A61P43/00 ,  C07H21/04 ,  C07K20060101 ,  C07K1/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/775 ,  C12N20060101 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/63 ,  C12N15/85 ,  C12P21/00 ,  C12P21/06 ,  C12Q20060101 ,  C12Q1/68 ,  G01N20060101 ,  G01N33/15 ,  G01N33/53 ,  G01N33/567 ,  G01N33/569

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/775

摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

摘要翻译： 本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。 本发明还涉及高骨量基因，相应的野生型基因及其突变体。 在本发明中鉴定的基因涉及骨发育。 本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 在骨发育。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

公开(公告)号：US06429303B1

公开(公告)日：2002-08-06

申请号：US09651200

申请日：2000-08-30

申请人： Cynthia Green ,  Victor Kotelianski ,  Antonin de Fougerolles ,  John Carulli ,  Catherine Hession

发明人： Cynthia Green ,  Victor Kotelianski ,  Antonin de Fougerolles ,  John Carulli ,  Catherine Hession

IPC分类号： C07H2104

CPC分类号： C07K14/70532 ,  A61K38/00 ,  Y10S435/81

摘要： An isolated BLAA polynucleotide and the membrane-associated or secreted polypeptide encoded by the BLAA polynucleotide are disclosed. Also disclosed are the antibodies that immunospecifically bind to a BLAA polypeptide or any derivative, variant, mutant or fragment of the BLAA polypeptide, polynucleotide or antibody. Also disclosed are nucleic acid vectors and host cells containing the nucleic acid sequence of the invention.

摘要翻译： 公开了分离的BLAA多核苷酸和由BLAA多核苷酸编码的膜相关或分泌的多肽。 还公开了免疫特异性结合BLAA多肽或BLAA多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 还公开了含有本发明的核酸序列的核酸载体和宿主细胞。