公开(公告)号：US20220265578A1

公开(公告)日：2022-08-25

申请号：US17692133

申请日：2022-03-10

申请人： PCT Therapeutics, Inc.

发明人： Paul Mollard ,  Peter Giannousis ,  Shazad Suchit ,  Mahmoud Mirmehrabi

IPC分类号： A61K31/122 ,  C07C235/78 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07B57/00 ,  A61K31/164 ,  C07C215/08

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US20150080383A1

公开(公告)日：2015-03-19

申请号：US14386524

申请日：2013-03-14

申请人： PCT Therapeutics Inc.

发明人： Tianle Yang ,  Gary Mitchell Karp ,  Hongyan Qi

IPC分类号： C07D405/04 ,  C07D487/04 ,  C07D311/22 ,  C07D417/04 ,  C07D405/14 ,  C07D471/04

CPC分类号： C07D405/04 ,  A61K31/352 ,  C07D311/22 ,  C07D311/26 ,  C07D311/30 ,  C07D405/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.