公开(公告)号：US09678085B2

公开(公告)日：2017-06-13

申请号：US14069052

申请日：2013-10-31

Applicant: Pathogen Removal and Diagnostic Technologies, Inc. ,  North Carolina State University

Inventor： David J. Hammond ,  Julia T. Lathrop ,  Larisa Cervenakova ,  Ruben G. Carbonell

IPC: G01N33/68 ,  C07K5/083 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K14/47

CPC classification number: G01N33/6896 ,  C07K5/0808 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0819 ,  C07K5/0821 ,  C07K14/47 ,  G01N2800/2828

Abstract: Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.

公开(公告)号：US20140206021A1

公开(公告)日：2014-07-24

申请号：US14069052

申请日：2013-10-31

Applicant: North Carolina State University ,  Pathogen Removal and Diagnostic Technologies, Inc.

Inventor： David J. Hammond ,  Julia T. Lathrop ,  Larisa Cervenakova ,  Ruben G. Carbonell

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  C07K5/0808 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0819 ,  C07K5/0821 ,  C07K14/47 ,  G01N2800/2828

Abstract: Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject

Abstract translation: 与朊病毒蛋白结合的配体和使用配体检测或从样品例如生物液体或环境样品中除去朊病毒蛋白的方法。 配体能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc）和重组朊蛋白（PrPr）。 来自各种物种的朊病毒，包括人类和仓鼠，都被配体结合。 还提供了治疗或延缓受试者中朊病毒相关病理学发展的方法

公开(公告)号：US20150284889A1

公开(公告)日：2015-10-08

申请号：US14746529

申请日：2015-06-22

Applicant: Pathogen Removal and Diagnostic Technologies, Inc. ,  North Carolina State University

Inventor： Yong Zheng ,  Sumana Roy Chowdhury ,  Patrick Vasconcelos Gurgel ,  Haiyan Liu ,  Ruben G. Carbonell

IPC: D04H1/56 ,  D06M10/00 ,  D06M14/22 ,  D06M14/32 ,  D06M14/28 ,  D06M14/34

CPC classification number: D04H1/56 ,  D04H1/42 ,  D04H1/565 ,  D04H1/587 ,  D04H1/64 ,  D04H1/641 ,  D06M10/001 ,  D06M10/025 ,  D06M14/22 ,  D06M14/26 ,  D06M14/28 ,  D06M14/32 ,  D06M14/34 ,  Y10T442/20 ,  Y10T442/277 ,  Y10T442/2861 ,  Y10T442/2877 ,  Y10T442/2885 ,  Y10T442/2893 ,  Y10T442/2902 ,  Y10T442/291 ,  Y10T442/2918 ,  Y10T442/60 ,  Y10T442/659

Abstract: The present invention describes a novel process for the conformal coating of polymer fibers on nonwoven substrates. This process is based on the modification of polymer fiber surfaces by controlling the degree of etching and oxidation, which improves adhesion of initiators to the surface and facilitates subsequent conformal polymer grafting. The modified fiber surfaces render new functionalities to the surface, such as increasing hydrophilicity, attaching ligands or changing surface energy. The invention includes the modified polymer fibers produced by the process described herein.

Abstract translation: 本发明描述了一种用于在非织造衬底上共聚涂覆聚合物纤维的新方法。 该方法基于通过控制蚀刻和氧化的程度来改进聚合物纤维表面，这改善了引发剂对表面的粘合性，并有助于随后的共形聚合物接枝。 改性纤维表面赋予表面新功能，例如增加亲水性，附着配体或改变表面能。 本发明包括通过本文所述方法生产的改性聚合物纤维。