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公开(公告)号：US08497268B2
公开(公告)日：2013-07-30
申请号：US13483892
申请日：2012-05-30
Applicant: H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/495
CPC classification number: C07D487/04 , C07C57/145
Abstract: Maleate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The salts are useful to provide blood levels of eszopiclone that are independent of fasting state.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。 这些盐可用于提供独立于空腹状态的依佐替克的血液水平。
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![L-MALATE SALTS OF 6-(5-CHLORO-2-PYRIDYL)-5-[(4-METHYL-1-PIPERAZINYL)CARBONYLOXY]-7-OXO-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRAZINE](/abs-image/US/2012/08/30/US20120220597A1/abs.jpg.150x150.jpg)
2.发明申请L-MALATE SALTS OF 6-(5-CHLORO-2-PYRIDYL)-5-[(4-METHYL-1-PIPERAZINYL)CARBONYLOXY]-7-OXO-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRAZINE 有权-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-（2-甲氧基苯基） B]吡嗪公开(公告)号：US20120220597A1
公开(公告)日：2012-08-30
申请号：US13470003
申请日：2012-05-11
Applicant: H. Scott WILKINSON , Richard HSIA , Tushar MISRA , Kostas SARANTEAS , Patrick MOUSAW
Inventor： H. Scott WILKINSON , Richard HSIA , Tushar MISRA , Kostas SARANTEAS , Patrick MOUSAW
IPC: A61K31/4985 , A61P25/20
CPC classification number: C07D487/04 , C07C59/245
Abstract: A novel L-malate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3 ，4-b]吡嗪）。
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![Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine](/abs-image/US/2012/06/12/US08198278B2/abs.jpg.150x150.jpg)
3.发明授权Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine 有权-5 - [（4-甲基-1-哌嗪基）羰基氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b] 吡嗪公开(公告)号：US08198278B2
公开(公告)日：2012-06-12
申请号：US12338903
申请日：2008-12-18
Applicant: Richard Hsia , H. Scott Wilkinson , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： Richard Hsia , H. Scott Wilkinson , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/495 , A61K31/4965
CPC classification number: C07D487/04
Abstract: Besylate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。
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4.发明授权Method for treating a sleep disorder with a dosage form of besylate salts of zopiclone or eszopiclone 有权用佐匹克隆或替佐氟龙的苯磺酸盐剂型治疗睡眠障碍的方法公开(公告)号：US08497267B2
公开(公告)日：2013-07-30
申请号：US13470046
申请日：2012-05-11
Applicant: Richard Hsia , H. Scott Wilkinson , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： Richard Hsia , H. Scott Wilkinson , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/495
CPC classification number: C07D487/04
Abstract: Besylate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.
Abstract translation: -5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。
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![L-Malate Salts of 6-(5-Chloro-2-Pyridyl)-5-[(4-Methyl-1-Piperazinyl)Carbonyloxy]-7-Oxo-6,7-Dihydro-5H-Pyrrolo[3,4-b]Pyrazine](/abs-image/US/2009/08/20/US20090209546A1/abs.jpg.150x150.jpg)
5.发明申请L-Malate Salts of 6-(5-Chloro-2-Pyridyl)-5-[(4-Methyl-1-Piperazinyl)Carbonyloxy]-7-Oxo-6,7-Dihydro-5H-Pyrrolo[3,4-b]Pyrazine 有权5-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4- b]吡嗪公开(公告)号：US20090209546A1
公开(公告)日：2009-08-20
申请号：US12338899
申请日：2008-12-18
Applicant: H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/4985 , C07D471/04
CPC classification number: C07D487/04 , C07C59/245
Abstract: A novel L-malate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3 ，4-b]吡嗪）。
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Patent Agency Ranking
6.发明授权Method for treating a sleep disorder with a dosage form of a zopiclone or eszopiclone L-malate salt 有权用佐匹克隆或左前列佐酮L-苹果酸盐治疗睡眠障碍的方法公开(公告)号：US08541416B2
公开(公告)日：2013-09-24
申请号：US13470003
申请日：2012-05-11
Applicant: H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/495
CPC classification number: C07D487/04 , C07C59/245
Abstract: L-malate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。
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![MALEATE SALTS OF 6-(5-CHLORO-2-PYRIDYL)-5-[(4-METHYL-1-PIPERAZINYL)CARBONYLOXY]-7-OXO-6,7-DIHYDRO-5H-PYRROLO[3,4-b]PYRAZINE](/abs-image/US/2012/09/20/US20120238580A1/abs.jpg.150x150.jpg)
7.发明申请MALEATE SALTS OF 6-(5-CHLORO-2-PYRIDYL)-5-[(4-METHYL-1-PIPERAZINYL)CARBONYLOXY]-7-OXO-6,7-DIHYDRO-5H-PYRROLO[3,4-b]PYRAZINE 有权-6 - （5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b] 吡嗪公开(公告)号：US20120238580A1
公开(公告)日：2012-09-20
申请号：US13483892
申请日：2012-05-30
Applicant: H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/4985 , A61P25/00
CPC classification number: C07D487/04 , C07C57/145
Abstract: A novel maleate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。
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![Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine](/abs-image/US/2012/09/18/US08268832B2/abs.jpg.150x150.jpg)
8.发明授权Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine 有权5 - [（4-甲基-1-哌嗪基）羰基氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b] 吡嗪公开(公告)号：US08268832B2
公开(公告)日：2012-09-18
申请号：US12338908
申请日：2008-12-18
Applicant: H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/4965
CPC classification number: C07D471/04
Abstract: Pharmaceutical compositions of maleate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b]pyrazine) are provided. The maleate salts are sleep agents useful in oral dosage forms.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,3- 4-b]吡嗪）。 马来酸盐是可用于口服剂型的睡眠剂。
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![Besylate Salts of 6-(5-Chloro-2-Pyridyl)-5-[(4 Methyl-1-Piperazinyl)Carbonyloxy]-7-oxo-6, 7-dihydro-5H-Pyrrolo[3,4-b]Pyrazine](/abs-image/US/2012/08/30/US20120220598A1/abs.jpg.150x150.jpg)
9.发明申请Besylate Salts of 6-(5-Chloro-2-Pyridyl)-5-[(4 Methyl-1-Piperazinyl)Carbonyloxy]-7-oxo-6, 7-dihydro-5H-Pyrrolo[3,4-b]Pyrazine 有权-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪的6-（5-氯-2-吡啶基）-5 -公开(公告)号：US20120220598A1
公开(公告)日：2012-08-30
申请号：US13470046
申请日：2012-05-11
Applicant: Richard HSIA , H. Scott Wilkinson , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： Richard HSIA , H. Scott Wilkinson , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/4985 , A61P25/20
CPC classification number: C07D487/04
Abstract: A novel besylate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。
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![Maleate Salts of 6-(5-Chloro-2-Pyridyl)-5-[(4-Methyl-1-Piperazinyl)Carbonyloxy]-7-oxo-6,7-dihydro-5H-Pyrrolo[3,4-b]Pyrazine](/abs-image/US/2009/08/27/US20090215784A1/abs.jpg.150x150.jpg)
10.发明申请Maleate Salts of 6-(5-Chloro-2-Pyridyl)-5-[(4-Methyl-1-Piperazinyl)Carbonyloxy]-7-oxo-6,7-dihydro-5H-Pyrrolo[3,4-b]Pyrazine 有权-5 - [（4-甲基-1-哌嗪基）羰基氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b] 吡嗪公开(公告)号：US20090215784A1
公开(公告)日：2009-08-27
申请号：US12338908
申请日：2008-12-18
Applicant: H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
Inventor： H. Scott Wilkinson , Richard Hsia , Tushar Misra , Kostas Saranteas , Patrick Mousaw
IPC: A61K31/4985 , C07D471/04
CPC classification number: C07D471/04
Abstract: A novel maleate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.
Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4 -b]吡嗪）。
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