公开(公告)号：US20090005457A1

公开(公告)日：2009-01-01

申请号：US12070888

申请日：2008-02-21

申请人： Michael Sizensky ,  Harold S. Wilkinson ,  John Snoonian ,  Norman Kim ,  Sharon M. Laughlin ,  Roger P. Bakale ,  Kevin Plunkett ,  Patrick Mousou

发明人： Michael Sizensky ,  Harold S. Wilkinson ,  John Snoonian ,  Norman Kim ,  Sharon M. Laughlin ,  Roger P. Bakale ,  Kevin Plunkett ,  Patrick Mousou

IPC分类号： A61K31/138 ,  C07C215/46 ,  A61P25/24 ,  A61P29/00 ,  A61P25/00 ,  A61P15/00

CPC分类号： C07C215/64 ,  C07B2200/07 ,  C07B2200/13 ,  C07C213/10 ,  C07C2601/14

摘要： Solid forms comprising a compound useful in the treatment, prevention and management of various conditions and diseases are provided herein. In particular, the invention provides solid forms comprising (−)—O-desmethylvenlafaxine, including salts thereof, having utility for the treatment, prevention and management of conditions and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.

摘要翻译： 本文提供了包含可用于治疗，预防和治疗各种病症和疾病的化合物的固体形式。 特别地，本发明提供了包含（ - ） - O-去甲基文拉法辛（包括其盐）的固体形式，其可用于治疗，预防和治疗病症和病症，包括但不限于情感障碍如抑郁症，双相和躁狂症 失调，注意力缺陷障碍，具有多动症的注意力缺陷障碍，帕金森病，癫痫，脑功能障碍，肥胖和体重增加，失禁，痴呆和相关疾病。