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1.发明申请Solid forms comprising (-)-O-desmethylvenlafaxine and uses thereof 审中-公开包含（ - ） - O-去甲基蓝法沙芬的固体形式及其用途公开(公告)号：US20090005457A1
公开(公告)日：2009-01-01
申请号：US12070888
申请日：2008-02-21
申请人： Michael Sizensky , Harold S. Wilkinson , John Snoonian , Norman Kim , Sharon M. Laughlin , Roger P. Bakale , Kevin Plunkett , Patrick Mousou
发明人： Michael Sizensky , Harold S. Wilkinson , John Snoonian , Norman Kim , Sharon M. Laughlin , Roger P. Bakale , Kevin Plunkett , Patrick Mousou
IPC分类号： A61K31/138 , C07C215/46 , A61P25/24 , A61P29/00 , A61P25/00 , A61P15/00
CPC分类号： C07C215/64 , C07B2200/07 , C07B2200/13 , C07C213/10 , C07C2601/14
摘要： Solid forms comprising a compound useful in the treatment, prevention and management of various conditions and diseases are provided herein. In particular, the invention provides solid forms comprising (−)—O-desmethylvenlafaxine, including salts thereof, having utility for the treatment, prevention and management of conditions and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.
摘要翻译： 本文提供了包含可用于治疗，预防和治疗各种病症和疾病的化合物的固体形式。 特别地，本发明提供了包含（ - ） - O-去甲基文拉法辛（包括其盐）的固体形式，其可用于治疗，预防和治疗病症和病症，包括但不限于情感障碍如抑郁症，双相和躁狂症 失调，注意力缺陷障碍，具有多动症的注意力缺陷障碍，帕金森病，癫痫，脑功能障碍，肥胖和体重增加，失禁，痴呆和相关疾病。
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2.发明授权公开(公告)号：US08957114B2
公开(公告)日：2015-02-17
申请号：US13513170
申请日：2010-12-03
申请人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Philip James Bonasia , Susan S. D'Souza
发明人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Philip James Bonasia , Susan S. D'Souza
IPC分类号： A01N33/02 , A61K31/135 , C07C211/00 , A61K9/20 , A61K9/48 , C07C211/42
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/4858 , C07C211/42
摘要： Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.
摘要翻译： 本文提供的药物组合物包含过度心律，盐和多形态的跨屈曲胆碱，制备组合物的方法，及其用于治疗包括抑郁症在内的CNS疾病的方法。
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公开(公告)号：US5760056A
公开(公告)日：1998-06-02
申请号：US808761
申请日：1997-03-03
IPC分类号： A61K9/48 , A61K31/00 , A61K31/192 , A61K31/4709 , A61K31/47
CPC分类号： A61K9/4858 , A61K31/00 , A61K31/192 , A61K31/4709 , A61K9/485
摘要： A pharmaceutical formulation comprising ##STR1## as the active ingredient, polyethylene glycol, NaOH, and water, wherein the mole equivalents of NaOH per mole equivalent of active ingredient is at least about 1.1, is suitable for soft gelatin capsule filling.
摘要翻译： 包含作为活性成分的作为活性成分的聚乙二醇，NaOH和水的药物制剂，其中每摩尔当量活性成分的NaOH摩尔当量为至少约1.1，适用于软明胶胶囊的填充。
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公开(公告)号：US06197787B1
公开(公告)日：2001-03-06
申请号：US09410600
申请日：1999-10-01
IPC分类号： A61K3170
CPC分类号： A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K31/00 , A61K31/192 , A61K31/4709
摘要： A method for preparing pharmaceutical formulations of poorly soluble drug substances in the form of concentrated solutions for filling soft gelatin capsules and solid dispersions and suspensions for filling hard gelatin capsules and compressing into tablets is provided. Pharmaceutical formulations of poorly soluble drug substances are also disclosed. The formulations include the sodium salt of the poorly soluble drug substance, a conversion aid such as PEG, polysorbate, a sugar alcohol (e.g. mannitol or xylitol), propylene glycol or transcutol, and, in some cases an excipient, such as dicalcium phosphate dihydrate, lactose monohydrate, or microcrystalline cellulose.
摘要翻译： 提供了用于填充软明胶胶囊的浓缩溶液形式的药物制剂的药物制剂和用于填充硬明胶胶囊并压制成片剂的固体分散体和悬浮液的方法。 还公开了难溶性药物的药物制剂。 制剂包括难溶性药物物质的钠盐，转化助剂例如PEG，聚山梨醇酯，糖醇（例如甘露醇或木糖醇），丙二醇或转酮醇，以及在一些情况下，赋形剂如磷酸二钙二水合物 ，乳糖一水合物或微晶纤维素。
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5.发明授权Stable pharmaceutical compositions containing tiludronate hydrates and process for producing the pharmaceutical compositions 失效含有替鲁膦酸盐水合物的稳定的药物组合物和用于制备药物组合物的方法
公开(公告)号：US5656288A
公开(公告)日：1997-08-12
申请号：US488986
申请日：1995-06-08
申请人： William Rocco , Sharon M. Laughlin
发明人： William Rocco , Sharon M. Laughlin
IPC分类号： A61K9/48 , A61K9/14 , A61K9/20 , A61K31/66 , A61K47/20 , A61P19/10 , A61P29/00 , A61P43/00 , C07F9/38 , A61K9/16 , A61K9/46
CPC分类号： A61K31/663 , A61K9/2013 , C07F9/3865
摘要： Disodium tiludronate tetrahydrate is provided for use in pharmaceutical compositions for oral administration in the form of a tablet, effervescent composition, capsule and the like.
摘要翻译： 提供四氢硬脂酸二钠四水合物用于以片剂，泡腾组合物，胶囊等形式口服给药的药物组合物。
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公开(公告)号：US20130116332A1
公开(公告)日：2013-05-09
申请号：US13513170
申请日：2010-12-03
申请人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Phillip James Bonasia , Susan S. D'souza
发明人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Phillip James Bonasia , Susan S. D'souza
IPC分类号： A61K31/135 , C07C211/42
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/4858 , C07C211/42
摘要： Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.
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公开(公告)号：US5776987A
公开(公告)日：1998-07-07
申请号：US810560
申请日：1997-03-03
IPC分类号： A61K9/48 , A61K9/66 , A61K31/00 , A61K31/192 , A61K31/4709 , A61K47/08 , A61K47/36
CPC分类号： A61K31/192 , A61K31/00 , A61K31/4709 , A61K9/4858 , A61K9/4866
摘要： A pharmaceutical suspension formulation comprising 0.1 to 40% by weight ##STR1## as the active ingredient; 0.1 to 40% by weight Transcutol; 0.1-99% by weight starch; 0-40% by weight polyethylene glycol, NaOH and water, wherein the mole equivalents of NaOH per mole equivalent of active ingredient is from 0.5 to 1.5 is particularly useful for filling hard gelatin capsules.
摘要翻译： 包含0.1至40重量％的作为活性成分的药物悬浮液制剂; 0.1〜40％（重量）Transcutol; 0.1-99重量％淀粉; 0-40重量％的聚乙二醇，NaOH和水，其中每摩尔当量活性成分的NaOH摩尔当量为0.5至1.5，特别适用于填充硬明胶胶囊。
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