公开(公告)号：US5444045A

公开(公告)日：1995-08-22

申请号：US947035

申请日：1992-09-17

申请人： Geoffrey L. Francis ,  Paul E. Walton ,  F. John Ballard ,  John P. McMurty ,  Patricia V. Phelps

发明人： Geoffrey L. Francis ,  Paul E. Walton ,  F. John Ballard ,  John P. McMurty ,  Patricia V. Phelps

IPC分类号： A61K38/00 ,  C07K14/65 ,  A61K35/12 ,  A61K38/22 ,  C07K14/00

CPC分类号： C07K14/65 ,  A61K38/00

摘要： A method of enhancing the growth of a bird is described. The method comprises (a) administering a compound selected from the group consisting of IGF-1, IGF-2 and active analogs thereof to a bird in ovo; then (b) incubating the bird to hatch; and then (c) growing the bird for at least three weeks after hatch. The compound is administered in ovo in an amount sufficient to enhance the growth of the bird at least three weeks after hatch. Preferred birds for practicing the present invention are chickens, and preferred compounds for practicing the present invention are IGF-1 and analogs thereof. The use of IGF-1, IGF-2 and active analogs thereof for the preparation of a medicament for administration to birds in ovo to ehance the growth of the bird at least three weeks after hatch is also disclosed, along with the pharmaceutical formulations so prepared.

摘要翻译： 描述了增强鸟类生长的方法。 该方法包括（a）将卵巢中的IGF-1，IGF-2及其活性类似物的化合物给予鸟; 然后（b）孵化鸟孵化; 然后（c）在孵化后至少三周生长鸟。 该化合物在卵内施用足以在孵化至少三周后增强鸟的生长。 用于实施本发明的优选的鸡是鸡，并且用于实施本发明的优选化合物是IGF-1及其类似物。 还公开了IGF-1，IGF-2及其活性类似物用于制备用于在卵内给予鸟类以增强鸟类生长至少三周的药物的药物，以及如此制备的药物制剂 。