Method of administering IGF-1, IGF-2, and analogs thereof to birds
    1.
    发明授权
    Method of administering IGF-1, IGF-2, and analogs thereof to birds 失效
    将IGF-1,IGF-2及其类似物给予鸟的方法

    公开(公告)号:US5444045A

    公开(公告)日:1995-08-22

    申请号:US947035

    申请日:1992-09-17

    CPC分类号: C07K14/65 A61K38/00

    摘要: A method of enhancing the growth of a bird is described. The method comprises (a) administering a compound selected from the group consisting of IGF-1, IGF-2 and active analogs thereof to a bird in ovo; then (b) incubating the bird to hatch; and then (c) growing the bird for at least three weeks after hatch. The compound is administered in ovo in an amount sufficient to enhance the growth of the bird at least three weeks after hatch. Preferred birds for practicing the present invention are chickens, and preferred compounds for practicing the present invention are IGF-1 and analogs thereof. The use of IGF-1, IGF-2 and active analogs thereof for the preparation of a medicament for administration to birds in ovo to ehance the growth of the bird at least three weeks after hatch is also disclosed, along with the pharmaceutical formulations so prepared.

    摘要翻译: 描述了增强鸟类生长的方法。 该方法包括(a)将卵巢中的IGF-1,IGF-2及其活性类似物的化合物给予鸟; 然后(b)孵化鸟孵化; 然后(c)在孵化后至少三周生长鸟。 该化合物在卵内施用足以在孵化至少三周后增强鸟的生长。 用于实施本发明的优选的鸡是鸡,并且用于实施本发明的优选化合物是IGF-1及其类似物。 还公开了IGF-1,IGF-2及其活性类似物用于制备用于在卵内给予鸟类以增强鸟类生长至少三周的药物的药物,以及如此制备的药物制剂 。

    Growth hormone fusion proteins, methods of production, and methods of
treatment
    2.
    发明授权
    Growth hormone fusion proteins, methods of production, and methods of treatment 失效
    生长激素融合蛋白,生产方法和治疗方法

    公开(公告)号:US5330971A

    公开(公告)日:1994-07-19

    申请号:US646616

    申请日:1991-01-22

    摘要: A plasmid encoding a fusion protein comprising a first polypeptide having growth hormone activity and a second polypeptide which may be one of insulin growth factor (IGF)-I or IGF-II and their analogues, chicken histone H2A.I or human transcription factor SPI-lac Z with an optional cleavage sequence between the first and second polypeptides. The fusion protein may be used: 1) to treat growth hormone deficiencies; 2) to suppress loss of body protein following trauma such as burns or infection; 3) for farm animals to increase growth rates and efficiency of food conversion; 4) and to support growth of cells in culture.

    摘要翻译: PCT No.PCT / AU90 / 00210 Sec。 371日期1991年1月22日 102(e)日期1991年1月22日PCT提交1990年5月22日PCT公布。 出版物WO90 / 15142 编码融合蛋白的质粒,其包含具有生长激素活性的第一多肽和可以是胰岛素生长因子(IGF)-I或IGF-II之一及其类似物的第二多肽,鸡组蛋白H2A。 I或人转录因子SPI-lacZ与第一和第二多肽之间的任选切割序列。 可以使用融合蛋白:1)治疗生长激素缺乏; 2)抑制烧伤或感染等创伤后身体蛋白质的损失; 3)为农场动物提高食物转化的增长率和效率; 4)并支持培养细胞的生长。