公开(公告)号：US09097130B2

公开(公告)日：2015-08-04

申请号：US13614114

申请日：2012-09-13

Applicant: Christopher Paul Willis ,  Richard Martin DiCintio ,  Lucas John Stoia

Inventor： Christopher Paul Willis ,  Richard Martin DiCintio ,  Lucas John Stoia

IPC: F01D11/02 ,  F23R3/28 ,  F23R3/34 ,  F01D11/00 ,  F23R3/00

CPC classification number: F01D11/005 ,  F05D2250/75 ,  F05D2260/38 ,  F23R3/002 ,  F23R3/283 ,  F23R3/34 ,  F23R2900/00012 ,  F23R2900/03042 ,  Y02E20/16

Abstract: A seal assembly for use between an injector and a combustion chamber in a gas turbine. A liner at least partially defines the combustion chamber, and the liner has at least one tubular liner collar, through which an injector is inserted. In one embodiment, the liner collar has a partially convex outer diameter and a floating collar is positioned at least partially around the liner collar. The floating collar has a retention member having a first end fixed to the floating collar and a second end configured to abut the convex outer diameter of liner collar, wherein the retention member maintains the floating collar at a radial distance from the injector less than a radial distance between the liner collar and the injector.

Abstract translation: 用于燃气轮机中的喷射器和燃烧室之间的密封组件。 至少部分地限定燃烧室的内衬，并且衬套具有至少一个管状衬套，注射器穿过衬套。 在一个实施例中，衬套具有部分凸起的外径，并且浮动套环至少部分地定位在衬套环周围。 浮动套环具有保持构件，该保持构件具有固定到浮动套环的第一端和构造成邻接衬套的凸形外径的第二端，其中保持构件将浮动衬套保持在比注射器小的径向距离 衬套和注射器之间的距离。

公开(公告)号：US20130227964A1

公开(公告)日：2013-09-05

申请号：US13410417

申请日：2012-03-02

Applicant: Christopher Paul Willis ,  William Lawrence Byrne ,  David William Cihlar ,  Donald Timothy Lemon ,  Patrick Benedict Melton

Inventor： Christopher Paul Willis ,  William Lawrence Byrne ,  David William Cihlar ,  Donald Timothy Lemon ,  Patrick Benedict Melton

IPC: F02C7/12 ,  F01D25/14

CPC classification number: F01D9/023

Abstract: A transition piece aft frame assembly is provided, and includes a transition piece aft frame and a heat shield. The transition piece aft frame has an aft face. At least a portion of the aft face is exposed to an exhaust gas stream. The heat shield is connected to the transition piece aft frame. The heat shield is oriented to generally deflect the exhaust gas stream away from the aft face of the transition piece aft frame.

Abstract translation: 提供过渡件后框架组件，并且包括过渡件后框架和隔热罩。 过渡件后框架有一个后面。 后表面的至少一部分暴露于排气流。 隔热罩与过渡件后框架连接。 隔热罩被定向成使废气流大致偏离过渡件后框架的后表面。

公开(公告)号：US20120165348A1

公开(公告)日：2012-06-28

申请号：US13137125

申请日：2011-07-21

Applicant: David Hardern ,  Anthony Ingall ,  Brian Springthorpe ,  Paul Willis ,  Simon Guile

Inventor： David Hardern ,  Anthony Ingall ,  Brian Springthorpe ,  Paul Willis ,  Simon Guile

IPC: A61K31/519 ,  A61P7/02 ,  C07D317/44 ,  A61P9/00 ,  C07D239/47 ,  C07D405/12 ,  C07D487/04 ,  A61P9/10

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07C211/40 ,  C07D239/48

Abstract: The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.

Abstract translation: 本发明提供新的三唑并[4,5-d]嘧啶化合物，它们作为药物的用途，含有它们的组合物及其制备方法。

公开(公告)号：US08012979B2

公开(公告)日：2011-09-06

申请号：US12062718

申请日：2008-04-04

Applicant: Matthew Hallam ,  Barrie Martin ,  Piotr Raubo ,  Bryan Roberts ,  Stephen St-Gallay ,  Paul Willis

Inventor： Matthew Hallam ,  Barrie Martin ,  Piotr Raubo ,  Bryan Roberts ,  Stephen St-Gallay ,  Paul Willis

IPC: C07D401/10 ,  C07D217/24 ,  A61K31/4725

CPC classification number: C07D217/24 ,  C07D217/26 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D487/08

Abstract: The present invention relates to isoquinolinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract translation: 本发明涉及式（I）的异喹啉酮衍生物：其中R1，R2，R3，R4，R5，R6和R7如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US20080214812A1

公开(公告)日：2008-09-04

申请号：US12149771

申请日：2008-05-08

Applicant: David Hardern ,  Anthony Ingall ,  Brian Springthorpe ,  Paul Willis ,  Simon Guile

Inventor： David Hardern ,  Anthony Ingall ,  Brian Springthorpe ,  Paul Willis ,  Simon Guile

IPC: C07D239/48

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07C211/40 ,  C07D239/48

Abstract: The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.

Abstract translation: 本发明提供新的三唑并[4,5-d]嘧啶化合物，它们作为药物的用途，含有它们的组合物及其制备方法。

公开(公告)号：US20080146612A1

公开(公告)日：2008-06-19

申请号：US11814530

申请日：2006-01-25

Applicant: Toby Thompson ,  Paul Willis

Inventor： Toby Thompson ,  Paul Willis

IPC: A61K31/4545 ,  C07C63/33 ,  C07D211/86 ,  C07D211/04 ,  A61P19/02 ,  A61P11/06 ,  A61P9/10 ,  A61K31/195 ,  A61K31/455

CPC classification number: C07C233/70 ,  C07C233/66 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D213/79 ,  C07D213/80 ,  C07D401/04

Abstract: The invention provides compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein Ar1 represents a group (II), (III), (IV) or (V), and A, Ar2, n, R1, R2, R3, R4 and R5 are as defined in the specification; a process for their preparation; pharmaceutical compositions containing them; and their use in therapy.

Abstract translation: 本发明提供式（I）化合物或其药学上可接受的盐，其中Ar 1代表（II），（III），（IV）或（V）组，A，Ar n，R 1，R 2，R 3，R 4，R 4， 和R 5如本说明书中所定义; 其准备过程; 含有它们的药物组合物; 及其在治疗中的应用。

公开(公告)号：US20050234077A1

公开(公告)日：2005-10-20

申请号：US11036682

申请日：2005-01-14

Applicant: Roger Bonnert ,  Peter Cage ,  Fraser Hunt ,  Iain Walters ,  Paul Willis

Inventor： Roger Bonnert ,  Peter Cage ,  Fraser Hunt ,  Iain Walters ,  Paul Willis

IPC: A61K31/522 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/04 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/00 ,  A61P25/06 ,  A61P25/14 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/08 ,  A61P31/18 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P41/00 ,  A61P43/00 ,  C07D473/24 ,  C07D487/04 ,  A61K31/519

CPC classification number: C07D473/24

Abstract: The invention provides certain heterocyclic compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy; in formula (I), A is a group of formula (a) or (b).

Abstract translation: 本发明提供某些杂环化合物，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途; 在式（I）中，A是式（a）或（b）的基团。

公开(公告)号：US06806273B1

公开(公告)日：2004-10-19

申请号：US09403392

申请日：2001-10-21

Applicant: Rupert Austin ,  Andrew Baxter ,  Roger Bonnert ,  Fraser Hunt ,  Elizabeth Kinchin ,  Paul Willis

Inventor： Rupert Austin ,  Andrew Baxter ,  Roger Bonnert ,  Fraser Hunt ,  Elizabeth Kinchin ,  Paul Willis

IPC: A61K31519

CPC classification number: C07D513/04

Abstract: The invention provides certain thiazolopyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract translation: 本发明提供某些噻唑并嘧啶化合物，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US06369064B1

公开(公告)日：2002-04-09

申请号：US09269330

申请日：1999-03-25

Applicant: Roger Brown ,  Garry Pairaudeau ,  Brian Springthorpe ,  Stephen Thom ,  Paul Willis

Inventor： Roger Brown ,  Garry Pairaudeau ,  Brian Springthorpe ,  Stephen Thom ,  Paul Willis

IPC: C07D23970

CPC classification number: C07D487/04

Abstract: Triazolo[4,5-d]pyrimidine compounds are provided of the formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification. Compositions containing the compounds are also provided, together with processes for their preparation and methods of use in the treatment of diseases, including myocardial infarction and unstable angina.

Abstract translation: 三唑并[4,5-d]嘧啶化合物由式（I）提供，其中R 1，R 2，R 3，R 4，R 5和R 6如说明书中所定义。 还提供了含有这些化合物的组合物及其制备方法和用于治疗包括心肌梗死和不稳定型心绞痛的疾病的方法。

公开(公告)号：US5747496A

公开(公告)日：1998-05-05

申请号：US737005

申请日：1996-10-31

Applicant: David Cox ,  Anthony Ingall ,  Paul Willis

Inventor： David Cox ,  Anthony Ingall ,  Paul Willis

IPC: A61K20060101 ,  A61K31/505 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07D20060101 ,  C07D403/04 ,  C07D487/04 ,  C07H19/06 ,  C07H19/16 ,  C07H19/23

CPC classification number: C07D487/04 ,  C07H19/06

Abstract: Compounds of the formula (I) ##STR1## wherein B is O or CH.sub.2 ; X is selected from NR.sup.1 R.sup.2, SR.sup.1, and C.sub.1 -C.sub.7 alkyl; Y is selected SR.sup.1, NR.sup.1 R.sup.2, and C.sub.1 -C.sub.7 alkyl; R.sup.1 and R.sup.2 is each and independently selected from H, or C.sub.1 -C.sub.7 alkyl optionally substituted upon or within the alkyl chain by one or more of O, S, N or halogen; R.sup.3 and R.sup.4 are both H, or R.sup.3 and R.sup.4 together form a bond; A is COOH, C(O)NH(CH.sub.2).sub.p COOH, C(O)N�(CH.sub.2).sub.q COOH!.sub.2, C(O)NHCH(COOH)(CH.sub.2).sub.r COOH, or 5-tetrazolyl, wherein p, q and r is each and independently 1, 2 or 3; as well as pharmaceutically acceptable salts and prodrugs thereof, pharmaceutical compositions comprising the novel compounds and use of the compounds in therapy. Also within the scope of the invention are novel intermediates to the novel compounds. The novel compounds are in particular useful in the prevention of platelet aggregation.

Abstract translation: PCT No.PCT / SE96 / 00911 Sec。 371日期：1996年10月31日 102（e）日期1996年10月31日PCT PCT 1996年7月4日PCT公布。 出版物WO97 / 03084 日期1997年1月30日式（I）其中B为O或CH 2的式（I）化合物 X选自NR1R2，SR1和C1-C7烷基; Y选自SR1，NR1R2和C1-C7烷基; R 1和R 2各自独立地选自H或在烷基链上任选被O，S，N或卤素中的一个或多个取代的C 1 -C 7烷基; R3和R4均为H或R3和R4一起形成键; A是COOH，C（O）NH（CH 2）p COOH，C（O）N [（CH 2）q COOH] 2，C（O）NHCH（COOH）（CH 2）r COOH或5-四唑基，其中p，q和 r各自独立地为1,2或3; 以及其药学上可接受的盐和前药，包含新化合物的药物组合物和化合物在治疗中的用途。 在本发明范围内也是新化合物的新中间体。 新型化合物特别可用于预防血小板聚集。