公开(公告)号：US06498033B1

公开(公告)日：2002-12-24

申请号：US09524004

申请日：2000-03-13

申请人： Boro Dropulic ,  Paula Pitha-Rowe

发明人： Boro Dropulic ,  Paula Pitha-Rowe

IPC分类号： C12N1586

CPC分类号： C12N15/1132 ,  A61K48/00 ,  C12N15/86 ,  C12N2740/16043

摘要： The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, the use of such a host cell to screen drugs. The methods include the prophylactic and therapeutic treatment of viral infection, in particular HIV infection, and, thus, are also directed to viral vaccines and the treatment of cancer, in particular cancer of viral etiology. Other methods include the use of such conditionally replicating viral vectors in gene therapy and other applications.

摘要翻译： 本发明提供了有条件地复制的病毒载体，制备，修饰，增殖和选择性包装的方法，以及使用这种载体，与这些载体相关的特定核苷酸和氨基酸序列的分离的分子，药物组合物和包含这样的载体的宿主细胞 一个载体，使用这样的宿主细胞筛选药物。 这些方法包括对病毒感染，特别是HIV感染的预防和治疗性治疗，因此也涉及病毒疫苗和治疗癌症，特别是病毒病因的癌症。 其他方法包括在基因治疗和其他应用中使用这种有条件复制的病毒载体。

公开(公告)号：US20060147421A1

公开(公告)日：2006-07-06

申请号：US11358007

申请日：2006-02-22

申请人： Paul Moore ,  Paula Pitha Rowe ,  Craig Rosen

发明人： Paul Moore ,  Paula Pitha Rowe ,  Craig Rosen

IPC分类号： C07K14/715 ,  C07H21/04 ,  C12P21/06 ,  A61K48/00 ,  C12N15/867

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K14/47 ,  C12N2799/027

摘要： The present invention relates to IRF3 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human IRF3 protein. IRF3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods of gene therapy using polynucleotides encoding IRF3 polypeptides, fragments or variants to treat, prevent or ameliorate infectious diseases.

公开(公告)号：US06410257B1

公开(公告)日：2002-06-25

申请号：US09562894

申请日：2000-05-01

申请人： Boro Dropulic ,  Paula Pitha-Rowe

发明人： Boro Dropulic ,  Paula Pitha-Rowe

IPC分类号： C12N1509

CPC分类号： C12N15/1132 ,  A61K48/00 ,  C12N15/86 ,  C12N2740/16043

摘要： The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, the use of such a host cell to screen drugs. The methods include the prophylactic and therapeutic treatment of viral infection, in particular HIV infection, and, thus, are also directed to vital vaccines and the treatment of cancer, in particular cancer of viral etiology. Other methods include the use of such conditionally replicating viral vectors in gene therapy and other applications.

摘要翻译： 本发明提供了有条件地复制的病毒载体，制备，修饰，增殖和选择性包装的方法，以及使用这种载体，与这些载体相关的特定核苷酸和氨基酸序列的分离的分子，药物组合物和包含这样的载体的宿主细胞 一个载体，使用这样的宿主细胞筛选药物。 这些方法包括病毒感染，特别是HIV感染的预防和治疗性治疗，因此还涉及重要疫苗和治疗癌症，特别是病毒病因学癌症。 其他方法包括在基因治疗和其他应用中使用这种有条件复制的病毒载体。