-
公开(公告)号：US07960367B2
公开(公告)日：2011-06-14
申请号：US10499214
申请日：2002-12-20
IPC分类号： A01N45/00
CPC分类号： A61K31/573 , A61K31/56 , A61K31/57
摘要： Steroid compounds processing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.
摘要翻译： 处于3β位置的氢供体的类固醇化合物以羟基或硫酸根的形式起作用，作为3α-羟基 - 孕甾 - 类固醇作用的有效阻断剂，因此作为治疗物质用于预防和/或 治疗类固醇相关性中枢神经系统疾病。 公开了基于这些物质施用的治疗方法，单独或组合的这些物质也被建议用于制造用于治疗许多特定类固醇诱导的CNS障碍的药物。
-
2.发明申请Gaba-Steroid Antagonists And Their Use For The Treatment Of Cns Disorders 有权Gaba类固醇拮抗剂及其用于治疗Cns疾病的用途公开(公告)号：US20080070876A1
公开(公告)日：2008-03-20
申请号：US11791160
申请日：2005-11-07
申请人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
发明人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
摘要： Compounds exhibiting 3alpha-hydroxy-5alpha/beta-steroid blocking action with no or only low antagonism against the gamma-aminobutyric acid (A) receptor (GABA-A), and compounds exhibiting partial antagonism against said receptor are presented. Methods for the prevention, treatment and/or alleviation of various CNS-disorders are suggested, as well as pharmaceutical compositions for such use.
摘要翻译： 呈现出对γ-氨基丁酸（A）受体（GABA-A）没有或只有低拮抗作用的3α-羟基-5α/β-类固醇阻断作用的化合物和对所述受体表现出部分拮抗作用的化合物。 建议预防，治疗和/或缓解各种CNS病症的方法，以及用于此类用途的药物组合物。
-
3.发明申请GABA-STEROID ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS 有权GABA-STEROID ANTAGONISTS及其用于治疗CNS疾病的用途公开(公告)号：US20120142657A1
公开(公告)日：2012-06-07
申请号：US13372389
申请日：2012-02-13
申请人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
发明人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
IPC分类号： A61K31/57 , A61P3/04 , A61P25/06 , A61P25/24 , A61P25/22 , A61P15/00 , A61P25/00 , A61P25/08
摘要： Compounds exhibiting 3alpha-hydroxy-5alpha/beta-steroid blocking action with no or only low antagonism against the gamma-aminobutyric acid (A) receptor (GABA-A), and compounds exhibiting partial antagonism against said receptor are presented. Methods for the prevention, treatment and/or alleviation of various CNS-disorders are suggested, as well as pharmaceutical compositions for such use.
摘要翻译： 呈现出对γ-氨基丁酸（A）受体（GABA-A）没有或只有低拮抗作用的3α-羟基-5α/β-类固醇阻断作用的化合物和对所述受体表现出部分拮抗作用的化合物。 建议预防，治疗和/或缓解各种CNS病症的方法，以及用于此类用途的药物组合物。
-
公开(公告)号：US08119619B2
公开(公告)日：2012-02-21
申请号：US12986937
申请日：2011-01-07
IPC分类号： A01N45/00
CPC分类号： A61K31/573 , A61K31/56 , A61K31/57
摘要： Steroid compounds possessing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.
摘要翻译： 具有3β位置的氢供体的类固醇化合物以羟基或硫酸根的形式起作用，作为3α-羟基 - 孕甾 - 类固醇作用的有效阻断剂，因此作为治疗物质用于预防和/或 治疗类固醇相关性中枢神经系统疾病。 公开了基于这些物质施用的治疗方法，单独或组合的这些物质也被建议用于制造用于治疗许多特定类固醇诱导的CNS障碍的药物。
-
5.发明申请PREGNANE STEROIDS AND THEIR USE IN THE TREATMENT OF CNS DISORDERS 失效PREGNANE STEROIDS及其在治疗CNS病症中的应用公开(公告)号：US20110098259A1
公开(公告)日：2011-04-28
申请号：US12986937
申请日：2011-01-07
IPC分类号： A61K31/57 , A61P25/00 , A61P25/28 , A61P25/08 , A61P25/10 , A61P25/12 , A61P25/24 , A61P25/22 , A61P25/26 , A61P25/30
CPC分类号： A61K31/573 , A61K31/56 , A61K31/57
摘要： Steroid compounds possessing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.
摘要翻译： 具有3β位置的氢供体的类固醇化合物以羟基或硫酸根的形式起作用，作为3α-羟基 - 孕甾 - 类固醇作用的有效阻断剂，因此作为治疗物质用于预防和/或 治疗类固醇相关性中枢神经系统疾病。 公开了基于这些物质施用的治疗方法，单独或组合的这些物质也被建议用于制造用于治疗许多特定类固醇诱导的CNS障碍的药物。
-
公开(公告)号：US07888340B2
公开(公告)日：2011-02-15
申请号：US10499214
申请日：2002-12-20
IPC分类号： A01N45/00
摘要： Steroid compounds processing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.
-
公开(公告)号：US20050222099A1
公开(公告)日：2005-10-06
申请号：US10499214
申请日：2002-12-20
IPC分类号： A61K45/00 , A61K31/56 , A61K31/57 , A61K31/573 , A61P3/04 , A61P5/28 , A61P15/08 , A61P15/16 , A61P15/18 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/28 , A61P29/00 , A61P43/00
CPC分类号： A61K31/573 , A61K31/56 , A61K31/57
摘要： Steroid compounds prossessing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.
摘要翻译： 以3-羟基 - 或硫酸根的形式，在3β位置中给予氢供体的类固醇化合物起着3α-羟基 - 孕甾 - 类固醇作用的有效阻断剂的作用，因此作为治疗物质用于预防和/或 治疗类固醇相关性中枢神经系统疾病。 公开了基于这些物质施用的治疗方法，单独或组合的这些物质也被建议用于制造用于治疗许多特定类固醇诱导的CNS障碍的药物。
-
8.发明授权GABA-steroid antagonists and their use for the treatment of CNS disorders 有权GABA类固醇拮抗剂及其用于治疗CNS疾病的用途公开(公告)号：US08372824B2
公开(公告)日：2013-02-12
申请号：US13372389
申请日：2012-02-13
申请人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
发明人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
摘要： Compounds exhibiting 3alpha-hydroxy-5alpha/beta-steroid blocking action with no or only low antagonism against the gamma-aminobutyric acid (A) receptor (GABA-A), and compounds exhibiting partial antagonism against said receptor are presented. Methods for the prevention, treatment and/or alleviation of various CNS-disorders are suggested, as well as pharmaceutical compositions for such use.
摘要翻译： 呈现出对γ-氨基丁酸（A）受体（GABA-A）没有或只有低拮抗作用的3α-羟基-5α/β-类固醇阻断作用的化合物和对所述受体表现出部分拮抗作用的化合物。 建议预防，治疗和/或缓解各种CNS病症的方法，以及用于此类用途的药物组合物。
-
9.发明授权GABA-steroid antagonists and their use for the treatment of CNS disorders 有权GABA类固醇拮抗剂及其用于治疗CNS疾病的用途公开(公告)号：US08114860B2
公开(公告)日：2012-02-14
申请号：US11791160
申请日：2005-11-07
申请人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
发明人： Torbjorn Backstrom , Per Lundgren , Ming-De Wang
摘要： Compounds exhibiting 3alpha-hydroxy-5alpha/beta-steroid blocking action with no or only low antagonism against the gamma-aminobutyric acid (A) receptor (GABA-A), and compounds exhibiting partial antagonism against said receptor are presented. Methods for the prevention, treatment and/or alleviation of various CNS-disorders are suggested, as well as pharmaceutical compositions for such use.
摘要翻译： 呈现出对γ-氨基丁酸（A）受体（GABA-A）没有或只有低拮抗作用的3α-羟基-5α/β-类固醇阻断作用的化合物和对所述受体表现出部分拮抗作用的化合物。 建议预防，治疗和/或缓解各种CNS病症的方法，以及用于此类用途的药物组合物。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.018 秒)