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公开(公告)号：US20090270460A1
公开(公告)日：2009-10-29
申请号：US12296534
申请日：2007-05-22
申请人： Michael Gregory Bell , Robert Anthony Doti , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Peter Rudolph Manninen , Jason Matthew Ochoada , Fucheng Qu , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
发明人： Michael Gregory Bell , Robert Anthony Doti , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Peter Rudolph Manninen , Jason Matthew Ochoada , Fucheng Qu , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
IPC分类号： A61K31/4439 , C07D231/12 , A61K31/415 , C07D277/02 , A61K31/426 , C07D401/02 , C07D275/04 , A61K31/428 , A61P9/00
CPC分类号： C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 公开了其中变量如本文所定义的式及其药物组合物和使用方法的化合物被公开用于治疗血脂异常和相关疾病。
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公开(公告)号：US06670373B1
公开(公告)日：2003-12-30
申请号：US10088721
申请日：2002-07-02
申请人： Rosanne Bonjouklian , Douglas Webb Johnson , Peter Ambrose Lander , Mark Christopher Lohman , Vinod Francis Patel , Sreenivasarao Vepachedu , Yongping Xie
发明人： Rosanne Bonjouklian , Douglas Webb Johnson , Peter Ambrose Lander , Mark Christopher Lohman , Vinod Francis Patel , Sreenivasarao Vepachedu , Yongping Xie
IPC分类号： A61K314745
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula (I), which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性赘生物。
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公开(公告)号：US07846960B2
公开(公告)日：2010-12-07
申请号：US12296534
申请日：2007-05-22
申请人： Michael Gregory Bell , Robert Anthony Doti , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Peter Rudolph Manninen , Jason Matthew Ochoada , Fucheng Qu , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
发明人： Michael Gregory Bell , Robert Anthony Doti , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Peter Rudolph Manninen , Jason Matthew Ochoada , Fucheng Qu , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 公开的其中变量如本文所定义的化合物及其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。
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公开(公告)号：US20080306125A1
公开(公告)日：2008-12-11
申请号：US12159224
申请日：2007-02-02
申请人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
发明人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
IPC分类号： A61K31/4245 , C07D261/06 , A61K31/422 , C07D275/04 , A61K31/428 , A61P3/10 , A61P9/10 , C07D277/20 , A61K31/426 , C07D271/10
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 式的化合物。 其中变量如本文所定义，并且其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。
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公开(公告)号：US06743794B2
公开(公告)日：2004-06-01
申请号：US10130800
申请日：2002-05-21
申请人： Rosanne Bonjouklian , Jeffrey Daniel Cohen , Joseph Michael Gruber , Douglas Webb Johnson , Louis Nickolaus Jungheim , Julian Stanley Kroin , Peter Ambrose Lander , Ho-Shen Lin , Mark Christopher Lohman , Brian Stephen Muehl , Bryan Hurst Norman , Vinod Francis Patel , Michael Enrico Richett , Kenneth Jeff Thrasher , Sreenivasarao Vepachedu , Wesley Todd White , Yongping Xie , Jeremy Schulenburg York , Brandon Lee Parkhurst , Qiupang Wang
发明人： Rosanne Bonjouklian , Jeffrey Daniel Cohen , Joseph Michael Gruber , Douglas Webb Johnson , Louis Nickolaus Jungheim , Julian Stanley Kroin , Peter Ambrose Lander , Ho-Shen Lin , Mark Christopher Lohman , Brian Stephen Muehl , Bryan Hurst Norman , Vinod Francis Patel , Michael Enrico Richett , Kenneth Jeff Thrasher , Sreenivasarao Vepachedu , Wesley Todd White , Yongping Xie , Jeremy Schulenburg York , Brandon Lee Parkhurst , Qiupang Wang
IPC分类号： A61K31496
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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公开(公告)号：US08106077B2
公开(公告)日：2012-01-31
申请号：US12298769
申请日：2007-05-22
申请人： Michael Gregory Bell , Robert Anthony Doti , Matthew Scott Dowling , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Nathan Bryan Mantlo , Jason Matthew Ochoada , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M Warshawsky
发明人： Michael Gregory Bell , Robert Anthony Doti , Matthew Scott Dowling , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Nathan Bryan Mantlo , Jason Matthew Ochoada , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M Warshawsky
IPC分类号： A61K31/4192 , C07D249/06
CPC分类号： C07D249/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 公开了其中变量如本文所定义的式（I）化合物及其药物组合物和使用方法用于治疗血脂异常和相关疾病。
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公开(公告)号：US07863302B2
公开(公告)日：2011-01-04
申请号：US12159224
申请日：2007-02-02
申请人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
发明人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
IPC分类号： A61K31/4245 , A61K31/422 , A61K31/428 , A61P3/10 , C07D261/06 , C07D275/04 , C07D277/20
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of formula and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 公开的化合物及其药物组合物和使用方法可用于治疗血脂异常和相关疾病。
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公开(公告)号：US20090093524A1
公开(公告)日：2009-04-09
申请号：US12298769
申请日：2007-05-22
申请人： Michael Gregory Bell , Robert Anthony Doti , Matthew Scott Dowling , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Nathan Bryan Mantlo , Jason Matthew Ochoada , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
发明人： Michael Gregory Bell , Robert Anthony Doti , Matthew Scott Dowling , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Nathan Bryan Mantlo , Jason Matthew Ochoada , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
IPC分类号： A61K31/4439 , C07D249/04 , A61K31/4192 , A61K31/404 , C07D275/04 , A61P3/10 , A61P9/10 , A61K31/428 , A61K31/416 , C07D401/02
CPC分类号： C07D249/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 公开了其中变量如本文所定义的式（I）化合物及其药物组合物和使用方法用于治疗血脂异常和相关疾病。
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公开(公告)号：US07470705B2
公开(公告)日：2008-12-30
申请号：US10598473
申请日：2005-03-17
申请人： Michael Gregory Bell , Guoqing Cao , Ana Maria Escribano , Maria Carmen Fernandez , Peter Ambrose Lander , Nathan Bryan Mantlo , Eva Maria Martin de la Nava , Ana Isabel Mateo Herranz , Daniel Ray Mayhugh , Xiaodong Wang
发明人： Michael Gregory Bell , Guoqing Cao , Ana Maria Escribano , Maria Carmen Fernandez , Peter Ambrose Lander , Nathan Bryan Mantlo , Eva Maria Martin de la Nava , Ana Isabel Mateo Herranz , Daniel Ray Mayhugh , Xiaodong Wang
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02
CPC分类号： C07D495/04 , C07D471/04 , C07D487/04
摘要： The present invention discloses compounds of formula (I) wherein A, n, q, K, W, X, Y; Z, R1, R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and its sequelae.
摘要翻译： 本发明公开了式（I）的化合物，其中A，n，q，K，W，X，Y; Z，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义，其药物组合物和使用方法被公开用于治疗血脂障碍及其后遗症。
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公开(公告)号：US07064131B2
公开(公告)日：2006-06-20
申请号：US10473218
申请日：2002-03-27
IPC分类号： A61K31/4402 , A61K31/4355 , C07D413/04
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I) which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
摘要翻译： 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性赘生物。
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