公开(公告)号：US4310464A

公开(公告)日：1982-01-12

申请号：US702732

申请日：1976-07-06

Applicant: Winston Costain ,  Bernard W. H. Terry ,  Nazim Punja ,  Peter J. V. Cleare

Inventor： Winston Costain ,  Bernard W. H. Terry ,  Nazim Punja ,  Peter J. V. Cleare

IPC: A01N43/08 ,  C07C51/00 ,  C07C51/58 ,  C07C57/52 ,  C07C57/76 ,  C07C67/00 ,  C07C69/65 ,  C07C69/743 ,  C07C69/747 ,  C07C253/00 ,  C07C255/23 ,  C07C255/48 ,  C07D307/33 ,  C07D307/32

CPC classification number: C07D307/33 ,  C07C51/58 ,  C07C57/52

Abstract: 4-.beta., .beta.-dichlorovinyl (or dibromovinyl)-3,3-dimethylbutyrolactones are prepared from 1,1-dichloro (or dibromo)-4-methylpenta-1,3-diene by reacting with an acid of formula CH.sub.2 R.CO.sub.2 H in presence of a salt of a metal in one of its higher valency states, especially manganese (III), cerium (IV), or vanadium (V). Higher yields are obtained in the presence of the anhydride of the acid and of the sodium or potassium salt of the acid. Treatment of the lactones with an inorganic acid halide opens the lactone ring with formation of the corresponding 4-haloacid halide, which with alcohols affords the corresponding 4-haloacid ester, cyclised by bases to a 3-.beta.,.beta.-dichloro (or dibromo)vinyl-2,2-dimethylcyclopropanecarboxylic ester, intermediate for insecticides such as the m-phenoxybenzyl ester.

Abstract translation: 由1,1-二氯（或二溴）-4-甲基戊-1,3-二烯通过与式CH2R.CO2H的酸反应制备4-β，β-二氯乙烯基（或二溴乙烯基）-3,3-二甲基丁内酯 在其较高价态之一，特别是锰（III），铈（IV）或钒（V）之一中存在金属盐。 在酸的酸酐和酸的钠盐或钾盐的存在下获得更高的产率。 用无机酰卤处理内酯，形成相应的4-卤代卤化物，使其与醇反应，形成相应的4-卤代酸酯，通过碱环化为3-β，β-二氯（或二溴） 乙烯基-2,2-二甲基环丙烷羧酸酯，间苯氧基苄基酯等杀虫剂的中间体。

公开(公告)号：US4173570A

公开(公告)日：1979-11-06

申请号：US925627

申请日：1978-07-17

Applicant: Peter J. V. Cleare

Inventor： Peter J. V. Cleare

IPC: C07C45/51 ,  C07C45/59 ,  C07C45/69 ,  C07C47/14 ,  C07C47/457 ,  C07D317/12 ,  C07D317/16 ,  C07D317/10

CPC classification number: C07C45/59 ,  C07C45/65 ,  C07C47/14 ,  C07C47/457 ,  C07D317/12 ,  C07D317/16

Abstract: The present invention relates to a process for the preparation of valuable chemical intermediates in the preparation of 2(2,2-dichlorovinyl)-3,3-dimethylcyclopropane carboxylic acid derivatives.

Abstract translation: 本发明涉及在制备2（2,2-二氯乙烯基）-3,3-二甲基环丙烷羧酸衍生物时制备有价值的化学中间体的方法。

公开(公告)号：US5451681A

公开(公告)日：1995-09-19

申请号：US366068

申请日：1994-12-29

Applicant: Harjinder S. Bansal ,  Peter J. V. Cleare

Inventor： Harjinder S. Bansal ,  Peter J. V. Cleare

IPC: C07D263/58 ,  C07D277/74

CPC classification number: C07D263/58 ,  C07D277/74

Abstract: A process for preparing a compound of formula (I) ##STR1## wherein X is oxygen or sulphur, by (a) reacting a substituted ortho-nitro or -nitroso phenol or a substituted ortho-nitro or -nitroso thiophenol with an alkali metal dithionite reducing agent in an alkaline reaction medium in the presence of carbon disulphide, to form a substituted 2-mercaptobenz-oxazole or -thiazole, acidifying the reaction mixture and collecting the 2-mercaptobenz-oxazole or -thiazole; and then (b) reacting the 2-mercaptobenz-oxazole or -thiazole with a compound of formula (IV)CF.sub.2 .dbd.CH--CH.sub.2 --CH.sub.2 --L (IV)wherein L is a good leaving group.

Abstract translation: 通过（a）使取代的邻硝基或亚硝基苯酚或取代的邻硝基或亚硝基苯硫酚与式（I）化合物反应，其中X是氧或硫， 在碱性反应介质中，在二硫化碳存在下，形成碱金属连二亚硫酸盐还原剂，形成取代的2-巯基苯并恶唑或噻唑，酸化反应混合物并收集2-巯基苯并恶唑或噻唑; 然后（b）使2-巯基苯并恶唑或噻唑与式（Ⅳ）化合物CF2 = CH-CH2-CH2-L（Ⅳ）反应，其中L是一个好的离去基团。

公开(公告)号：US4927852A

公开(公告)日：1990-05-22

申请号：US229532

申请日：1988-08-08

Applicant: Michael J. Robson ,  Peter J. V. Cleare ,  Mark A. Spinney

Inventor： Michael J. Robson ,  Peter J. V. Cleare ,  Mark A. Spinney

IPC: C07B61/00 ,  A01N53/00 ,  A01N53/06 ,  A01P7/04 ,  C07C67/03 ,  C07C67/08 ,  C07C67/10 ,  C07C67/14 ,  C07C69/74 ,  C07C69/743

CPC classification number: A01N53/00

Abstract: The invention provides insecticidal compositions exhibiting excellent knockdown activity against public health pests, in particular cockroach species, comprising compounds of formula (I): ##STR1## wherein X represents a group of formula: ##STR2## where (i) R.sup.1 and R.sup.2 are each selected from hydrogen, halo and C.sub.1-4 alkyl, or (ii) R.sup.1 is hydrogen and R.sup.2 represents either R.sup.3 (R.sup.4)C.dbd.CH-- or R.sup.3 (R.sup.4)(R.sup.5)C--CH(R.sup.5)--, where R.sup.3 and R.sup.4 are selected from hydrogen, methyl, halo and C.sub.1-2 haloalkyl and R.sup.5 is selected from chloro and bromo. The invention also provides methods of use of the compositions, novel compounds of formula (I) and processes for their preparation.

公开(公告)号：US4128585A

公开(公告)日：1978-12-05

申请号：US862519

申请日：1977-12-20

Applicant: Peter J. V. Cleare

Inventor： Peter J. V. Cleare

IPC: C07C45/51 ,  C07C45/59 ,  C07C45/69 ,  C07C47/14 ,  C07C47/457 ,  C07D317/12 ,  C07D317/16 ,  C07C47/02

CPC classification number: C07D317/16 ,  C07C45/59 ,  C07C45/65 ,  C07C47/457 ,  C07D317/12

Abstract: A compound of formula: ##STR1## where Q, R and Z are independently selected from chlorine or bromine provided that Q is always bromine when either of R and Z are bromine.

Abstract translation: 其中Q，R和Z独立地选自氯或溴，式中的化合物：其中当R和Z都是溴时，Q总是溴。