公开(公告)号：US20140249051A1

公开(公告)日：2014-09-04

申请号：US14342255

申请日：2012-08-30

申请人： Todd Lambert Lowary ,  Christopher Warren Cairo ,  Lori Jeanne West ,  Jillian Mary Buriak ,  Peter John Meloncelli ,  Mylvaganam Jeyakanthan ,  Anne Margaret Slaney

发明人： Todd Lambert Lowary ,  Christopher Warren Cairo ,  Lori Jeanne West ,  Jillian Mary Buriak ,  Peter John Meloncelli ,  Mylvaganam Jeyakanthan ,  Anne Margaret Slaney

IPC分类号： G01N33/68

CPC分类号： G01N33/6854 ,  G01N33/66 ,  G01N33/80 ,  G01N2400/00

摘要： The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO-compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo-blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo-blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject. Profiles can be established by applying a sample to an array of surface-bound ABO antigens selected from the group of type I to type VI antigens of each blood group A, B or H.

摘要翻译： 本申请公开了一种用于ABO抗体检测和表征的系统和方法，其可以提供用于评估和管理ABO不相容和ABO兼容的移植物的替代手段。 该方法和系统包括使用来自受试者的生物样品测定受试者的抗ABO血型抗原亚型抗体谱。 该方法和系统可用于通过将确定的受体受试者的抗ABO抗原亚型抗体谱与ABO组织血型或ABO组织血液亚组比较来评估供体血液或组织产品对受体受试者的适合性 的供体血液或组织产品。 为了定义受试者的ABO组织血液亚组，将确定的抗体谱与已知的ABO组织血型抗原亚型谱和/或ABO组织血液亚组的已知抗ABO抗原亚型抗体特征进行比较，以鉴定ABO组织 对象的-blood子组。 可以通过将样品应用于选自每个血型A，B或H的I型至VI型抗原组的表面结合的ABO抗原阵列来建立分布。

公开(公告)号：US08974793B2

公开(公告)日：2015-03-10

申请号：US13139387

申请日：2009-12-11

申请人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanthan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

发明人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanthan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

IPC分类号： A61K39/00 ,  A61L31/16 ,  A61K47/48 ,  A61K49/04 ,  B82Y5/00

CPC分类号： A61L31/16 ,  A61K39/001 ,  A61K47/48215 ,  A61K47/48861 ,  A61K47/60 ,  A61K47/6923 ,  A61K49/0423 ,  A61K2039/55555 ,  A61K2039/6093 ,  A61K2039/627 ,  A61L2300/438 ,  A61L2300/80 ,  B82Y5/00

摘要： Described herein are methods and systems that can be used to induce immunologic tolerance to non-self antigens. The methods and systems comprise introducing a tolerogen comprising at least one immunogenic non-self antigen coupled to a carrier, wherein the immunogenic antigen can be a foreign or endogenous antigen or fragments thereof. The non-self antigen can be selected from the group consisting of carbohydrate antigens, full-length antigenic proteins, and fragments and combinations thereof, while the carrier can be selected from nanoparticles and stents. Tolerogen compositions are also provided and can be used to induce immunologic tolerance to non-self antigens. These methods, systems and compositions are particularly advantageous since they can be used to allow for the extension of the window of safety for immunologically-incompatible transplantations to patients who are growing past the age of infancy.

摘要翻译： 本文描述了可用于诱导对非自身抗原的免疫耐受性的方法和系统。 所述方法和系统包括引入包含与载体偶联的至少一种免疫原性非自身抗原的耐受原，其中所述免疫原性抗原可以是外源或内源性抗原或其片段。 非自身抗原可以选自碳水化合物抗原，全长抗原蛋白及其片段及其组合，而载体可选自纳米颗粒和支架。 还提供了耐受性组合物并且可以用于诱导对非自身抗原的免疫耐受性。 这些方法，系统和组合物是特别有利的，因为它们可用于允许将免疫不相容的移植的安全窗口延伸到正在妊娠年龄的患者中。

公开(公告)号：US20120021056A1

公开(公告)日：2012-01-26

申请号：US13139387

申请日：2009-12-11

申请人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanathan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

发明人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanathan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

IPC分类号： A61K9/14 ,  A61P37/06 ,  A61K39/385

CPC分类号： A61L31/16 ,  A61K39/001 ,  A61K47/48215 ,  A61K47/48861 ,  A61K47/60 ,  A61K47/6923 ,  A61K49/0423 ,  A61K2039/55555 ,  A61K2039/6093 ,  A61K2039/627 ,  A61L2300/438 ,  A61L2300/80 ,  B82Y5/00

摘要： Described herein are methods and systems that can be used to induce immunologic tolerance to non-self antigens. The methods and systems comprise introducing a tolerogen comprising at least one immunogenic non-self antigen coupled to a carrier, wherein the immunogenic antigen can be a foreign or endogenous antigen or fragments thereof. The non-self antigen can be selected from the group consisting of carbohydrate antigens, full-length antigenic proteins, and fragments and combinations thereof, while the carrier can be selected from nanoparticles and stents. Tolerogen compositions are also provided and can be used to induce immunologic tolerance to non-self antigens. These methods, systems and compositions are particularly advantageous since they can be used to allow for the extension of the window of safety for immunologically-incompatible transplantations to patients who are growing past the age of infancy.

摘要翻译： 本文描述了可用于诱导对非自身抗原的免疫耐受性的方法和系统。 所述方法和系统包括引入包含与载体偶联的至少一种免疫原性非自身抗原的耐受原，其中所述免疫原性抗原可以是外源或内源性抗原或其片段。 非自身抗原可以选自碳水化合物抗原，全长抗原蛋白及其片段及其组合，而载体可选自纳米颗粒和支架。 还提供了耐受性组合物并且可以用于诱导对非自身抗原的免疫耐受性。 这些方法，系统和组合物是特别有利的，因为它们可用于允许将免疫不相容的移植的安全窗口延伸到正在妊娠年龄的患者中。