公开(公告)号：US08974793B2

公开(公告)日：2015-03-10

申请号：US13139387

申请日：2009-12-11

申请人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanthan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

发明人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanthan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

IPC分类号： A61K39/00 ,  A61L31/16 ,  A61K47/48 ,  A61K49/04 ,  B82Y5/00

CPC分类号： A61L31/16 ,  A61K39/001 ,  A61K47/48215 ,  A61K47/48861 ,  A61K47/60 ,  A61K47/6923 ,  A61K49/0423 ,  A61K2039/55555 ,  A61K2039/6093 ,  A61K2039/627 ,  A61L2300/438 ,  A61L2300/80 ,  B82Y5/00

摘要： Described herein are methods and systems that can be used to induce immunologic tolerance to non-self antigens. The methods and systems comprise introducing a tolerogen comprising at least one immunogenic non-self antigen coupled to a carrier, wherein the immunogenic antigen can be a foreign or endogenous antigen or fragments thereof. The non-self antigen can be selected from the group consisting of carbohydrate antigens, full-length antigenic proteins, and fragments and combinations thereof, while the carrier can be selected from nanoparticles and stents. Tolerogen compositions are also provided and can be used to induce immunologic tolerance to non-self antigens. These methods, systems and compositions are particularly advantageous since they can be used to allow for the extension of the window of safety for immunologically-incompatible transplantations to patients who are growing past the age of infancy.

摘要翻译： 本文描述了可用于诱导对非自身抗原的免疫耐受性的方法和系统。 所述方法和系统包括引入包含与载体偶联的至少一种免疫原性非自身抗原的耐受原，其中所述免疫原性抗原可以是外源或内源性抗原或其片段。 非自身抗原可以选自碳水化合物抗原，全长抗原蛋白及其片段及其组合，而载体可选自纳米颗粒和支架。 还提供了耐受性组合物并且可以用于诱导对非自身抗原的免疫耐受性。 这些方法，系统和组合物是特别有利的，因为它们可用于允许将免疫不相容的移植的安全窗口延伸到正在妊娠年龄的患者中。

公开(公告)号：US20120021056A1

公开(公告)日：2012-01-26

申请号：US13139387

申请日：2009-12-11

申请人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanathan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

发明人： Lori Jeanne West ,  Todd Lambert Lowary ,  Jillian Mary Buriak ,  Brian Daly ,  Mylvaganam Jeyakanathan ,  Peter John Meloncelli ,  Vincent Arthur Wright ,  Anne Margaret Cooper

IPC分类号： A61K9/14 ,  A61P37/06 ,  A61K39/385

CPC分类号： A61L31/16 ,  A61K39/001 ,  A61K47/48215 ,  A61K47/48861 ,  A61K47/60 ,  A61K47/6923 ,  A61K49/0423 ,  A61K2039/55555 ,  A61K2039/6093 ,  A61K2039/627 ,  A61L2300/438 ,  A61L2300/80 ,  B82Y5/00

摘要： Described herein are methods and systems that can be used to induce immunologic tolerance to non-self antigens. The methods and systems comprise introducing a tolerogen comprising at least one immunogenic non-self antigen coupled to a carrier, wherein the immunogenic antigen can be a foreign or endogenous antigen or fragments thereof. The non-self antigen can be selected from the group consisting of carbohydrate antigens, full-length antigenic proteins, and fragments and combinations thereof, while the carrier can be selected from nanoparticles and stents. Tolerogen compositions are also provided and can be used to induce immunologic tolerance to non-self antigens. These methods, systems and compositions are particularly advantageous since they can be used to allow for the extension of the window of safety for immunologically-incompatible transplantations to patients who are growing past the age of infancy.

摘要翻译： 本文描述了可用于诱导对非自身抗原的免疫耐受性的方法和系统。 所述方法和系统包括引入包含与载体偶联的至少一种免疫原性非自身抗原的耐受原，其中所述免疫原性抗原可以是外源或内源性抗原或其片段。 非自身抗原可以选自碳水化合物抗原，全长抗原蛋白及其片段及其组合，而载体可选自纳米颗粒和支架。 还提供了耐受性组合物并且可以用于诱导对非自身抗原的免疫耐受性。 这些方法，系统和组合物是特别有利的，因为它们可用于允许将免疫不相容的移植的安全窗口延伸到正在妊娠年龄的患者中。